通过RNA测序数据分析研究circRNA/lncRNA-miRNA-mRNA网络的最新进展

IF 2.5 3区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Yulan Gao, Konii Takenaka, Si-Mei Xu, Yuning Cheng, Michael Janitz
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引用次数: 0

摘要

非编码RNA (ncRNAs)是从DNA转录而来的RNA分子,但不翻译成蛋白质。过去几十年的研究表明,根据基因组大小和结构,ncrna可分为小rna、长链非编码rna和环状rna。越来越多的证据表明,这些非编码转录物通过转录和翻译调节基因表达,从而塑造细胞功能和疾病发病机制。值得注意的是,最近的研究已经研究了ncRNAs作为竞争性内源性rna (ceRNAs)的功能,该功能可以隔离miRNAs并调节mrna的表达。ceRNAs网络作为一个关键的调控功能出现,在各种疾病如癌症和神经退行性疾病中具有重要意义。因此,我们强调了旨在预测cerna相互作用的多种生物信息学工具和数据库。此外,我们讨论了使用当前技术的局限性和潜在的改进,以检测cerna网络。了解cerna内部的动态相互作用可以促进生物学理解,并为治疗干预提供潜在的靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recent advances in investigation of circRNA/lncRNA-miRNA-mRNA networks through RNA sequencing data analysis.

Non-coding RNAs (ncRNAs) are RNA molecules that are transcribed from DNA but are not translated into proteins. Studies over the past decades have revealed that ncRNAs can be classified into small RNAs, long non-coding RNAs and circular RNAs by genomic size and structure. Accumulated evidences have eludicated the critical roles of these non-coding transcripts in regulating gene expression through transcription and translation, thereby shaping cellular function and disease pathogenesis. Notably, recent studies have investigated the function of ncRNAs as competitive endogenous RNAs (ceRNAs) that sequester miRNAs and modulate mRNAs expression. The ceRNAs network emerges as a pivotal regulatory function, with significant implications in various diseases such as cancer and neurodegenerative disease. Therefore, we highlighted multiple bioinformatics tools and databases that aim to predict ceRNAs interaction. Furthermore, we discussed limitations of using current technologies and potential improvement for ceRNAs network detection. Understanding of the dynamic interplay within ceRNAs may advance the biological comprehension, as well as providing potential targets for therapeutic intervention.

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来源期刊
Briefings in Functional Genomics
Briefings in Functional Genomics BIOTECHNOLOGY & APPLIED MICROBIOLOGY-GENETICS & HEREDITY
CiteScore
6.30
自引率
2.50%
发文量
37
审稿时长
6-12 weeks
期刊介绍: Briefings in Functional Genomics publishes high quality peer reviewed articles that focus on the use, development or exploitation of genomic approaches, and their application to all areas of biological research. As well as exploring thematic areas where these techniques and protocols are being used, articles review the impact that these approaches have had, or are likely to have, on their field. Subjects covered by the Journal include but are not restricted to: the identification and functional characterisation of coding and non-coding features in genomes, microarray technologies, gene expression profiling, next generation sequencing, pharmacogenomics, phenomics, SNP technologies, transgenic systems, mutation screens and genotyping. Articles range in scope and depth from the introductory level to specific details of protocols and analyses, encompassing bacterial, fungal, plant, animal and human data. The editorial board welcome the submission of review articles for publication. Essential criteria for the publication of papers is that they do not contain primary data, and that they are high quality, clearly written review articles which provide a balanced, highly informative and up to date perspective to researchers in the field of functional genomics.
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