使用泊松自回归(PAR)模型研究阿尔及利亚COVID-19传染动力学的贝叶斯方法

IF 1.2 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Ahmed Hamimes, Hani Amir Aouissi, Feriel Kheira Kebaili, Zeinab A Kasemy
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引用次数: 0

摘要

全球的重点一直放在跟踪COVID-19大流行的趋势上。为此目的已经开发或利用了许多技术。在本研究中,我们试图以阿尔及利亚为案例研究,提出并评估一个我们认为尚未得到充分重视的模型。我们使用蒙特卡罗马尔可夫链(MCMC)模拟方法和贝叶斯方法开发了两种不同的泊松自回归(PAR)模型:一种模型仅基于短期依赖性,另一种模型结合了短期和长期依赖性。这项研究旨在应用这些模型来提高对新感染的预测,并确定这种疾病是在传播还是在下降。这些信息可以指导有关实施或放松遏制措施的决定。结果表明,研究期末阿尔及利亚的流行病学状况相对稳定,长期和短期综合依赖因子均小于1 (α+β=0.994)。这表明,虽然该流行病在减少,但预计感染率在不久的将来不会显著下降。此外,短期依赖参数α=0.987占总依赖的显著部分(99%)。这一高α值表明,阿尔及利亚的COVID-19疫情正在大幅下降,尽管在可预见的未来,预计新感染率将维持在较低水平。鉴于这些调查结果,建议当局保持警惕,继续采取公共卫生措施,包括开展教育运动和提高认识工作,以促进COVID-19疫苗接种和遵守健康指南。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Bayesian approach for studying COVID-19 contagion dynamics in Algeria using a Poisson autoregressive (PAR) model.

Global emphasis has been focused on tracking the trends of the COVID-19 pandemic. Numerous techniques have been developed or utilized for this purpose. In this study, we seek to present and evaluate a model that, in our opinion, has not received adequate attention, using Algeria as a case study. We developed two distinct Poisson autoregressive (PAR) models using the Monte Carlo Markov Chain (MCMC) simulation method and the Bayesian method: one based solely on short-term dependence and the other incorporating both short- and long-term dependence. The study aimed to apply these models to enhance the prediction of new infections and determine whether the disease is spreading or declining. This information can guide decisions on implementing or relaxing containment measures. Our findings suggest that Algeria's epidemiological state was relatively stable at the end of the study period, with the combined long-term and short-term dependence factors being less than 1 (α+β=0.994). This indicates that while the epidemic is in decline, the infection rates are not expected to drop significantly in the near future. Furthermore, the short-term dependence parameter α=0.987constitutes a significant portion (99%) of the total dependence. This high value of α suggest that the COVID-19 epidemic in Algeria is experiencing a strong decline, though the rate of new infections is expected to persist at a lower level for the foreseeable future. Given these findings, it is recommended that authorities remain vigilant and continue public health measures, including educational campaigns and awareness efforts, to promote COVID-19 vaccination and adherence to health guidelines.

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来源期刊
Journal of Biopharmaceutical Statistics
Journal of Biopharmaceutical Statistics 医学-统计学与概率论
CiteScore
2.50
自引率
18.20%
发文量
71
审稿时长
6-12 weeks
期刊介绍: The Journal of Biopharmaceutical Statistics, a rapid publication journal, discusses quality applications of statistics in biopharmaceutical research and development. Now publishing six times per year, it includes expositions of statistical methodology with immediate applicability to biopharmaceutical research in the form of full-length and short manuscripts, review articles, selected/invited conference papers, short articles, and letters to the editor. Addressing timely and provocative topics important to the biostatistical profession, the journal covers: Drug, device, and biological research and development; Drug screening and drug design; Assessment of pharmacological activity; Pharmaceutical formulation and scale-up; Preclinical safety assessment; Bioavailability, bioequivalence, and pharmacokinetics; Phase, I, II, and III clinical development including complex innovative designs; Premarket approval assessment of clinical safety; Postmarketing surveillance; Big data and artificial intelligence and applications.
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