Florent Eymard, Karine Louati, Éric Noel, Redouane Abouqal, Philippe Adam, Fadoua Allali, Gabriel Antherieu, Jo Caers, Fabrice Cognasse, Hervé Collado, Christelle Darrieutort-Laffite, Corinne Frère, Alain Frey, Mathilde Gavillet, Vincent Gremeaux, Mael Heiblig, Guy Jerusalem, Charlotte Joly, Jean-François Kaux, Martin Lamontagne, Mathieu Leclerc, Philippe Léonard, Raphaël Lepeule, Daniel Lopez-Trabada-Ataz, Jérémy Magalon, Fabrice Michel, Paul Ornetti, Cécile Oury, Elvire Pons-Tostivint, Fernando Real, Ghislaine Robert, Mikel Sanchez, Alain Silvestre, Hervé Bard
{"title":"富血小板血浆注射治疗感染性、肿瘤性和血液学合并症的肌肉骨骼疾病的适应症和禁忌症：2025年GRIIP（国际血小板注射研究小组）正式共识。","authors":"Florent Eymard, Karine Louati, Éric Noel, Redouane Abouqal, Philippe Adam, Fadoua Allali, Gabriel Antherieu, Jo Caers, Fabrice Cognasse, Hervé Collado, Christelle Darrieutort-Laffite, Corinne Frère, Alain Frey, Mathilde Gavillet, Vincent Gremeaux, Mael Heiblig, Guy Jerusalem, Charlotte Joly, Jean-François Kaux, Martin Lamontagne, Mathieu Leclerc, Philippe Léonard, Raphaël Lepeule, Daniel Lopez-Trabada-Ataz, Jérémy Magalon, Fabrice Michel, Paul Ornetti, Cécile Oury, Elvire Pons-Tostivint, Fernando Real, Ghislaine Robert, Mikel Sanchez, Alain Silvestre, Hervé Bard","doi":"10.1002/ksa.12682","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Purpose</h3>\n \n <p>Platelet-rich plasma (PRP) could be a vector for certain diseases, and its composition may vary by pathologic condition. The main comorbidities that could affect PRP composition are infectious, oncologic and haematologic. In addition to potential alteration of clinical response, these pathologies could have a significant impact on the local tolerance of PRP as well as a risk of disease dissemination to the injection site. To date, there are few specific recommendations related to these comorbidities to guide clinicians. Therefore, the International Research Group on Platelet Injections (GRIIP) supported a consensus project to develop these recommendations.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Following the ‘recommendations by formal consensus’ methodology, a steering committee performed a literature review and drafted an initial set of recommendations. They were evaluated by an international rating group (15 specialists in musculoskeletal [MSK] diseases, five haematologists, four oncologists, three infectiologists and four scientists specialising in platelet physiology). From this rating, the first set of recommendations was discussed in a plenary meeting and then modified by the steering committee. Finally, four overarching principles and 23 recommendations were re-evaluated by the rating group. Recommendations were classified as appropriate or not, with strong or relative agreement, or uncertain.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>From the 23 recommendations, 10 concerned infectious diseases (viral and bacterial infections; dialysis; immunosuppressive drugs; dental care…), five oncologic diseases (local tumour; cured, active or in remission cancer…) and eight haematologic diseases (cytopenia; cured, active or stabilised cured hemopathy; monoclonal gammopathy…). All were considered appropriate by the experts (median = 9; range = 8–9), with strong or relative agreement. Due to the paucity of literature data, the recommendations are mainly based on expert opinion (Grade D).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>This consensus project provides four overarching principles and 23 recommendations related to contraindications of PRP injections in case of infectious, oncologic or hematologic diseases, validated by an international expert group.</p>\n </section>\n \n <section>\n \n <h3> Level of Evidence</h3>\n \n <p>Level I.</p>\n </section>\n </div>","PeriodicalId":17880,"journal":{"name":"Knee Surgery, Sports Traumatology, Arthroscopy","volume":"33 6","pages":"2293-2306"},"PeriodicalIF":3.3000,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ksa.12682","citationCount":"0","resultStr":"{\"title\":\"Indications and contraindications to platelet-rich plasma injections in musculoskeletal diseases in case of infectious, oncological and haematological comorbidities: A 2025 formal consensus from the GRIIP (International Research Group on Platelet Injections)\",\"authors\":\"Florent Eymard, Karine Louati, Éric Noel, Redouane Abouqal, Philippe Adam, Fadoua Allali, Gabriel Antherieu, Jo Caers, Fabrice Cognasse, Hervé Collado, Christelle Darrieutort-Laffite, Corinne Frère, Alain Frey, Mathilde Gavillet, Vincent Gremeaux, Mael Heiblig, Guy Jerusalem, Charlotte Joly, Jean-François Kaux, Martin Lamontagne, Mathieu Leclerc, Philippe Léonard, Raphaël Lepeule, Daniel Lopez-Trabada-Ataz, Jérémy Magalon, Fabrice Michel, Paul Ornetti, Cécile Oury, Elvire Pons-Tostivint, Fernando Real, Ghislaine Robert, Mikel Sanchez, Alain Silvestre, Hervé Bard\",\"doi\":\"10.1002/ksa.12682\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Purpose</h3>\\n \\n <p>Platelet-rich plasma (PRP) could be a vector for certain diseases, and its composition may vary by pathologic condition. 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Indications and contraindications to platelet-rich plasma injections in musculoskeletal diseases in case of infectious, oncological and haematological comorbidities: A 2025 formal consensus from the GRIIP (International Research Group on Platelet Injections)
Purpose
Platelet-rich plasma (PRP) could be a vector for certain diseases, and its composition may vary by pathologic condition. The main comorbidities that could affect PRP composition are infectious, oncologic and haematologic. In addition to potential alteration of clinical response, these pathologies could have a significant impact on the local tolerance of PRP as well as a risk of disease dissemination to the injection site. To date, there are few specific recommendations related to these comorbidities to guide clinicians. Therefore, the International Research Group on Platelet Injections (GRIIP) supported a consensus project to develop these recommendations.
Methods
Following the ‘recommendations by formal consensus’ methodology, a steering committee performed a literature review and drafted an initial set of recommendations. They were evaluated by an international rating group (15 specialists in musculoskeletal [MSK] diseases, five haematologists, four oncologists, three infectiologists and four scientists specialising in platelet physiology). From this rating, the first set of recommendations was discussed in a plenary meeting and then modified by the steering committee. Finally, four overarching principles and 23 recommendations were re-evaluated by the rating group. Recommendations were classified as appropriate or not, with strong or relative agreement, or uncertain.
Results
From the 23 recommendations, 10 concerned infectious diseases (viral and bacterial infections; dialysis; immunosuppressive drugs; dental care…), five oncologic diseases (local tumour; cured, active or in remission cancer…) and eight haematologic diseases (cytopenia; cured, active or stabilised cured hemopathy; monoclonal gammopathy…). All were considered appropriate by the experts (median = 9; range = 8–9), with strong or relative agreement. Due to the paucity of literature data, the recommendations are mainly based on expert opinion (Grade D).
Conclusion
This consensus project provides four overarching principles and 23 recommendations related to contraindications of PRP injections in case of infectious, oncologic or hematologic diseases, validated by an international expert group.
期刊介绍：
Few other areas of orthopedic surgery and traumatology have undergone such a dramatic evolution in the last 10 years as knee surgery, arthroscopy and sports traumatology. Ranked among the top 33% of journals in both Orthopedics and Sports Sciences, the goal of this European journal is to publish papers about innovative knee surgery, sports trauma surgery and arthroscopy. Each issue features a series of peer-reviewed articles that deal with diagnosis and management and with basic research. Each issue also contains at least one review article about an important clinical problem. Case presentations or short notes about technical innovations are also accepted for publication.
The articles cover all aspects of knee surgery and all types of sports trauma; in addition, epidemiology, diagnosis, treatment and prevention, and all types of arthroscopy (not only the knee but also the shoulder, elbow, wrist, hip, ankle, etc.) are addressed. Articles on new diagnostic techniques such as MRI and ultrasound and high-quality articles about the biomechanics of joints, muscles and tendons are included. Although this is largely a clinical journal, it is also open to basic research with clinical relevance.
Because the journal is supported by a distinguished European Editorial Board, assisted by an international Advisory Board, you can be assured that the journal maintains the highest standards.
Official Clinical Journal of the European Society of Sports Traumatology, Knee Surgery and Arthroscopy (ESSKA).
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