Iwona Gorczyca-Głowacka, Agata Galas, Agata Tymińska, Katarzyna Byczkowska, Anna Furman-Niedziejko, Michał Tkaczyszyn, Adrian Stefański, Agnieszka Major, Dominika Klimczak-Tomaniak, Piotr Hamala, Małgorzata Zachura, Mateusz Staciwa, Maciej Nadel, Robert Morawiec
{"title":"心力衰竭观察性研究（HEROES）的一份报告：射血分数降低、轻度降低和保留的心力衰竭患者心房颤动。","authors":"Iwona Gorczyca-Głowacka, Agata Galas, Agata Tymińska, Katarzyna Byczkowska, Anna Furman-Niedziejko, Michał Tkaczyszyn, Adrian Stefański, Agnieszka Major, Dominika Klimczak-Tomaniak, Piotr Hamala, Małgorzata Zachura, Mateusz Staciwa, Maciej Nadel, Robert Morawiec","doi":"10.33963/v.phj.105590","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Heart failure (HF) and atrial fibrillation (AF) often coexist and modify each other's course. The prevalence and clinical characteristic of AF differ in specific HF subtypes.</p><p><strong>Aims: </strong>The study aimed to evaluate the incidence and clinical features of people with AF in comparison to those with sinus rhythm in HF, across the three HF subtypes categorized by left ventricular ejection fraction (EF).</p><p><strong>Methods: </strong>Hospitalized patients and outpatients were enrolled in the Heart failuReObsErvationalStudy, a prospective, multicenter cohort study. HF subtypes were defined as reduced EF (HFrEF, EF<40%), mildly reduced EF (HFmrEF, EF 40%-49%) or preserved EF(HFpEF, EF≥50%).</p><p><strong>Results: </strong>A total of 1,210 patients with HF were included in the study (71.8% male). Among them, 51.8% had HFrEF, 21.7% had HFmrEF, and 26.5% had HFpEF. Within the entire HF study population, 79.5% were hospitalized, and AF was present in 51.8% of patients. The prevalence of AF was 53.9% in HFrEF, 49.7% in HFmrEF, and 51.7% in HFpEF (P=0.59). The strongest factors independently associated with AF in different HF subtypes were echocardiographic abnormalities: aortic regurgitation in patients with HFpEF (OR 9.02, CI 1.14-71.27, P<0.001), left atrial volume > median in patients with HFmrEF (OR 6.21, CI 2.24-17.2, P<0.001) and in patients with HFrEF (OR 3.9, CI 2.21-6.90, P<0.001). Selected independent associations with AF were similar in HFpEF, HFmrEF, and HFrEF groups.</p><p><strong>Conclusions: </strong>In the population with HF, the AF incidence is similar in the HFrEF, HFmrEF and HFpEF groups. It is associated with similar clinical characteristics in HF subtypes.</p>","PeriodicalId":17784,"journal":{"name":"Kardiologia polska","volume":" ","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Atrial fibrillation in patients with heart failure with reduced, mildly reduced, and preserved ejection fraction: a report from the HEart failuRe ObsErvational Study (HEROES).\",\"authors\":\"Iwona Gorczyca-Głowacka, Agata Galas, Agata Tymińska, Katarzyna Byczkowska, Anna Furman-Niedziejko, Michał Tkaczyszyn, Adrian Stefański, Agnieszka Major, Dominika Klimczak-Tomaniak, Piotr Hamala, Małgorzata Zachura, Mateusz Staciwa, Maciej Nadel, Robert Morawiec\",\"doi\":\"10.33963/v.phj.105590\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Heart failure (HF) and atrial fibrillation (AF) often coexist and modify each other's course. The prevalence and clinical characteristic of AF differ in specific HF subtypes.</p><p><strong>Aims: </strong>The study aimed to evaluate the incidence and clinical features of people with AF in comparison to those with sinus rhythm in HF, across the three HF subtypes categorized by left ventricular ejection fraction (EF).</p><p><strong>Methods: </strong>Hospitalized patients and outpatients were enrolled in the Heart failuReObsErvationalStudy, a prospective, multicenter cohort study. HF subtypes were defined as reduced EF (HFrEF, EF<40%), mildly reduced EF (HFmrEF, EF 40%-49%) or preserved EF(HFpEF, EF≥50%).</p><p><strong>Results: </strong>A total of 1,210 patients with HF were included in the study (71.8% male). Among them, 51.8% had HFrEF, 21.7% had HFmrEF, and 26.5% had HFpEF. Within the entire HF study population, 79.5% were hospitalized, and AF was present in 51.8% of patients. The prevalence of AF was 53.9% in HFrEF, 49.7% in HFmrEF, and 51.7% in HFpEF (P=0.59). The strongest factors independently associated with AF in different HF subtypes were echocardiographic abnormalities: aortic regurgitation in patients with HFpEF (OR 9.02, CI 1.14-71.27, P<0.001), left atrial volume > median in patients with HFmrEF (OR 6.21, CI 2.24-17.2, P<0.001) and in patients with HFrEF (OR 3.9, CI 2.21-6.90, P<0.001). Selected independent associations with AF were similar in HFpEF, HFmrEF, and HFrEF groups.</p><p><strong>Conclusions: </strong>In the population with HF, the AF incidence is similar in the HFrEF, HFmrEF and HFpEF groups. It is associated with similar clinical characteristics in HF subtypes.</p>\",\"PeriodicalId\":17784,\"journal\":{\"name\":\"Kardiologia polska\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-04-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Kardiologia polska\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.33963/v.phj.105590\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Kardiologia polska","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.33963/v.phj.105590","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
摘要
背景：心力衰竭（HF）和心房颤动（AF）经常共存并改变彼此的病程。房颤的患病率和临床特征在特定HF亚型中有所不同。目的：本研究旨在通过左心室射血分数（EF）分类的三种HF亚型，评估房颤患者与心衰窦性心律患者的发病率和临床特征。方法：住院患者和门诊患者被纳入心衰观察性研究，这是一项前瞻性、多中心队列研究。HF亚型被定义为EF降低（HFrEF, eff）。结果：共有1210例HF患者纳入研究，其中71.8%为男性。其中，HFrEF占51.8%，HFmrEF占21.7%，HFpEF占26.5%。在整个HF研究人群中，79.5%的患者住院，51.8%的患者存在房颤。HFrEF组AF患病率为53.9%，HFmrEF组为49.7%，HFpEF组为51.7% （P=0.59）。不同HF亚型中与房颤独立相关的最强因素是超声心动图异常：HFpEF患者主动脉瓣返流(OR 9.02, CI 1.14-71.27， HFmrEF患者P中位值（OR 6.21, CI 2.24-17.2， P）。结论：在HF人群中，HFrEF、HFmrEF和HFpEF组房颤发生率相似。它与HF亚型相似的临床特征相关。
Atrial fibrillation in patients with heart failure with reduced, mildly reduced, and preserved ejection fraction: a report from the HEart failuRe ObsErvational Study (HEROES).
Background: Heart failure (HF) and atrial fibrillation (AF) often coexist and modify each other's course. The prevalence and clinical characteristic of AF differ in specific HF subtypes.
Aims: The study aimed to evaluate the incidence and clinical features of people with AF in comparison to those with sinus rhythm in HF, across the three HF subtypes categorized by left ventricular ejection fraction (EF).
Methods: Hospitalized patients and outpatients were enrolled in the Heart failuReObsErvationalStudy, a prospective, multicenter cohort study. HF subtypes were defined as reduced EF (HFrEF, EF<40%), mildly reduced EF (HFmrEF, EF 40%-49%) or preserved EF(HFpEF, EF≥50%).
Results: A total of 1,210 patients with HF were included in the study (71.8% male). Among them, 51.8% had HFrEF, 21.7% had HFmrEF, and 26.5% had HFpEF. Within the entire HF study population, 79.5% were hospitalized, and AF was present in 51.8% of patients. The prevalence of AF was 53.9% in HFrEF, 49.7% in HFmrEF, and 51.7% in HFpEF (P=0.59). The strongest factors independently associated with AF in different HF subtypes were echocardiographic abnormalities: aortic regurgitation in patients with HFpEF (OR 9.02, CI 1.14-71.27, P<0.001), left atrial volume > median in patients with HFmrEF (OR 6.21, CI 2.24-17.2, P<0.001) and in patients with HFrEF (OR 3.9, CI 2.21-6.90, P<0.001). Selected independent associations with AF were similar in HFpEF, HFmrEF, and HFrEF groups.
Conclusions: In the population with HF, the AF incidence is similar in the HFrEF, HFmrEF and HFpEF groups. It is associated with similar clinical characteristics in HF subtypes.
期刊介绍：
Kardiologia Polska (Kardiol Pol, Polish Heart Journal) is the official peer-reviewed journal of the Polish Cardiac Society (PTK, Polskie Towarzystwo Kardiologiczne) published monthly since 1957. It aims to provide a platform for sharing knowledge in cardiology, from basic science to translational and clinical research on cardiovascular diseases.
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