{"title":"皮损内维生素D3治疗皮肤疣的作用。","authors":"Sabahat Shah, Seemab Khan, Noor Us Sabah","doi":"10.29271/jcpsp.2025.05.642","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To determine the effect of intralesional vitamin D3 injection in the treatment of cutaneous warts.</p><p><strong>Study design: </strong>Quasi-experimental study. Place and Duration of the Study: Department of Dermatology, P.N.S. Shifa Hospital, Karachi, Pakistan, from May to November 2023.</p><p><strong>Methodology: </strong>A total of 30 patients with cutaneous warts of various sizes and durations were selected. Vitamin D3 (0.2 ml, 15 mg/ml) was injected to the base of the warts after anaesthetising with lignocaine (0.2 ml, 20 mg/ml). The injections were repeated two weeks apart for a maximum of 4 sessions or until complete clearance, whichever was earlier. A maximum of two warts were treated per session, and patients were followed up for six months after the last injection.</p><p><strong>Results: </strong>The patients' average age was 32.20 ± 11.9 years, and their average illness duration was 14.3 ± 6.5 months. Out of the 30 patients, 10 (33.4%) were females and 20 (66.6%) were males. Twenty cases (66.6%) showed complete clearance, seven cases (23.3%) showed a moderate response, and three (10%) showed a mild response. The only side effects observed in 17 (56.6%) cases were mild swelling and irritation at the injection site, both of which went away on their own within a few days.</p><p><strong>Conclusion: </strong>Intralesional vitamin D3 is an effective and affordable treatment option for cutaneous warts.</p><p><strong>Key words: </strong>Cutaneous warts, Common warts, Efficacy, Intralesional treatment, Vitamin D3.</p>","PeriodicalId":54905,"journal":{"name":"Jcpsp-Journal of the College of Physicians and Surgeons Pakistan","volume":"35 5","pages":"642-645"},"PeriodicalIF":0.7000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Role of Intralesional Vitamin D3 in the Treatment of Cutaneous Warts.\",\"authors\":\"Sabahat Shah, Seemab Khan, Noor Us Sabah\",\"doi\":\"10.29271/jcpsp.2025.05.642\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To determine the effect of intralesional vitamin D3 injection in the treatment of cutaneous warts.</p><p><strong>Study design: </strong>Quasi-experimental study. Place and Duration of the Study: Department of Dermatology, P.N.S. Shifa Hospital, Karachi, Pakistan, from May to November 2023.</p><p><strong>Methodology: </strong>A total of 30 patients with cutaneous warts of various sizes and durations were selected. Vitamin D3 (0.2 ml, 15 mg/ml) was injected to the base of the warts after anaesthetising with lignocaine (0.2 ml, 20 mg/ml). The injections were repeated two weeks apart for a maximum of 4 sessions or until complete clearance, whichever was earlier. A maximum of two warts were treated per session, and patients were followed up for six months after the last injection.</p><p><strong>Results: </strong>The patients' average age was 32.20 ± 11.9 years, and their average illness duration was 14.3 ± 6.5 months. Out of the 30 patients, 10 (33.4%) were females and 20 (66.6%) were males. Twenty cases (66.6%) showed complete clearance, seven cases (23.3%) showed a moderate response, and three (10%) showed a mild response. The only side effects observed in 17 (56.6%) cases were mild swelling and irritation at the injection site, both of which went away on their own within a few days.</p><p><strong>Conclusion: </strong>Intralesional vitamin D3 is an effective and affordable treatment option for cutaneous warts.</p><p><strong>Key words: </strong>Cutaneous warts, Common warts, Efficacy, Intralesional treatment, Vitamin D3.</p>\",\"PeriodicalId\":54905,\"journal\":{\"name\":\"Jcpsp-Journal of the College of Physicians and Surgeons Pakistan\",\"volume\":\"35 5\",\"pages\":\"642-645\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Jcpsp-Journal of the College of Physicians and Surgeons Pakistan\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.29271/jcpsp.2025.05.642\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Jcpsp-Journal of the College of Physicians and Surgeons Pakistan","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.29271/jcpsp.2025.05.642","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Role of Intralesional Vitamin D3 in the Treatment of Cutaneous Warts.
Objective: To determine the effect of intralesional vitamin D3 injection in the treatment of cutaneous warts.
Study design: Quasi-experimental study. Place and Duration of the Study: Department of Dermatology, P.N.S. Shifa Hospital, Karachi, Pakistan, from May to November 2023.
Methodology: A total of 30 patients with cutaneous warts of various sizes and durations were selected. Vitamin D3 (0.2 ml, 15 mg/ml) was injected to the base of the warts after anaesthetising with lignocaine (0.2 ml, 20 mg/ml). The injections were repeated two weeks apart for a maximum of 4 sessions or until complete clearance, whichever was earlier. A maximum of two warts were treated per session, and patients were followed up for six months after the last injection.
Results: The patients' average age was 32.20 ± 11.9 years, and their average illness duration was 14.3 ± 6.5 months. Out of the 30 patients, 10 (33.4%) were females and 20 (66.6%) were males. Twenty cases (66.6%) showed complete clearance, seven cases (23.3%) showed a moderate response, and three (10%) showed a mild response. The only side effects observed in 17 (56.6%) cases were mild swelling and irritation at the injection site, both of which went away on their own within a few days.
Conclusion: Intralesional vitamin D3 is an effective and affordable treatment option for cutaneous warts.
期刊介绍：
Journal of College of Physicians and Surgeons Pakistan (JCPSP), is the prestigious, peer reviewed monthly biomedical journal of the country published regularly since 1991.
Established with the primary aim of promotion and dissemination of medical research and contributed by scholars of biomedical sciences from Pakistan and abroad, it carries original research papers, , case reports, review articles, articles on medical education, commentaries, short communication, new technology, editorials and letters to the editor. It covers the core biomedical health science subjects, basic medical sciences and emerging community problems, prepared in accordance with the “Uniform requirements for submission to bio-medical journals” laid down by International Committee of Medical Journals Editors (ICMJE). All publications of JCPSP are peer reviewed by subject specialists from Pakistan and locally and abroad.
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