加强抗生素管理计划对四家泰国医院抗生素管理的影响。

IF 2.3 Q2 HEALTH CARE SCIENCES & SERVICES
Kittiya Jantarathaneewat PharmD, BCP, BCIDP (Research Group in Infectious Diseases Epidemiology and Prevention, Faculty of Medicine, and Center of Excellence in Pharmacy Practice and Management Research, Faculty of Pharmacy, Thammasat University, Pathum Thani, Thailand), Anucha Thatrimontrichai MD (Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand), Nattapol Pruetpongpun MD (Department of Medicine, Bangkok Phitsanulok Hospital, Phitsanulok, Thailand), Siriththin Chansirikarnjana MD (Division of Infectious Diseases, Lerdsin Hospital, Bangkok, Thailand), Sasinuch Rutjanawech MD (Research Group in Infectious Diseases Epidemiology and Prevention, Faculty of Medicine, and Division of Infectious Diseases, Faculty of Medicine, Thammasat University), David J. Weber MD, MPH (Gillings School of Global Public Health, University of North Carolina School of Medicine), Anucha Apisarnthanarak MD (Research Group in Infectious Diseases Epidemiology and Prevention, Faculty of Medicine, and Division of Infectious Diseases, Faculty of Medicine, Thammasat University. Please address correspondence to Anucha Apisarnthanarak)
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引用次数: 0

摘要

背景:抗菌药物管理计划(ASP)对于减少不适当的抗菌药物使用,改善患者预后和对抗日益增加的抗菌药物耐药性至关重要。然而,关于亚洲加强ASP网络实施情况的数据有限。方法:这项准实验研究评估了2021年和2022年期间泰国四家医院(两所大学医院、一家三级保健中心和一家私立医院)的ASP协作网络。基线ASP活动使用差距分析调查进行评估。通过抗生素用量(每日限定剂量,每1000患者日的DDD)、抗生素使用的适宜性和多重耐药菌(mdro)的发生率来衡量有效性。结果:增强的ASP网络解决了关键挑战,导致ASP实施方面的重大改进。值得注意的成果包括目标抗生素使用的总体适宜性增加(86.5%对74.4%,p < 0.05),所有医院的目标抗生素使用量减少。一家医院耐碳青霉烯鲍曼不动杆菌(30.22 vs. 6.08 / 1000患者-天,p < 0.05)和耐甲氧西林金黄色葡萄球菌(1.90 vs. 0.46 / 1000患者-天,p < 0.05)的MDROs发生率均显著下降。两家医院实施强化ASP后,耐多药病原菌的发病率有所下降。结论:本研究中增强的网络计划显著改善了泰国不同医院环境中ASP的实施。它解决了财政支持不足等挑战。在抗生素使用的适宜性和总体抗生素消费方面观察到显著的改善,可能有助于减少耐多药病原体。这些发现突出了合作ASP网络在亚洲的有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Enhanced Antibiotic Stewardship Program's Effect on Antibiotic Stewardship in Four Thai Hospitals

Background

An antimicrobial stewardship program (ASP) is crucial for reducing inappropriate antimicrobial use, improving patient outcomes, and combating increasing antimicrobial resistance. However, data on the implementation of enhanced ASP networks in Asia are limited.

Methods

This quasi-experimental study evaluated an ASP collaborative network across four hospitals in Thailand (two university hospitals, a tertiary care center, and a private hospital) during 2021 and 2022. Baseline ASP activities were assessed using gap analysis surveys. Effectiveness was measured through antibiotic consumption (daily defined dose, [DDD] per 1,000 patient-days), appropriateness of antibiotic use, and the incidence of multidrug-resistant organisms (MDROs).

Results

The enhanced ASP network addressed key challenges, leading to significant improvements in ASP implementation. Notable achievements included an increase in the overall appropriateness of target antibiotic use (86.5% vs. 74.4 %, p < 0.05) and a reduction in target antibiotic consumptions in all hospitals. The incidence of MDROs, including carbapenem-resistant Acinetobacter baumannii (30.22 vs. 6.08 per 1,000 patient-days, p < 0.05) and methicillin-resistant Staphylococcus aureus (1.90 vs. 0.46 per 1,000 patient-days, p < 0.05), declined significantly in one hospital. The incidence of multidrug-resistant pathogens declined after the implementation of the enhanced ASP in two hospitals.

Conclusion

The enhanced networking program in this study significantly improved ASP implementation across diverse hospital settings in Thailand. It addressed challenges such as insufficient financial support. Notable improvements were observed in the appropriateness of antibiotic use and overall antibiotic consumption, potentially contributing to the reduction in multidrug-resistant pathogens. These findings highlight the effectiveness of a collaborative ASP network in Asia.
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CiteScore
3.80
自引率
4.30%
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