Luciane Alves da Rocha Amorim, Nathalie Jeanne Bravo-Valenzuela, Sophia Livas de Morais Almeida, Alberto Borges Peixoto, Luiz Henrique Soares Nicoloso, Márcia Moura Schmidt, Paulo Zielinsky, Edward Araujo Júnior
{"title":"利用二维脉冲多普勒超声心动图在妊娠16 ~ 33+6周的正常胎儿中测量房室间期的Z-score方程的建立。","authors":"Luciane Alves da Rocha Amorim, Nathalie Jeanne Bravo-Valenzuela, Sophia Livas de Morais Almeida, Alberto Borges Peixoto, Luiz Henrique Soares Nicoloso, Márcia Moura Schmidt, Paulo Zielinsky, Edward Araujo Júnior","doi":"10.14366/usg.24142","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Fetal echocardiography is the primary diagnostic tool for assessing the atrioventricular (AV) time interval. Establishing a reference range for this parameter throughout pregnancy is essential for the early detection of potential abnormalities. The aim of this study was to develop a Z-score equation and establish specific percentiles for the AV time interval in normal fetuses between 16 and 33+6 weeks of gestation.</p><p><strong>Methods: </strong>A multicenter, prospective, cross-sectional study was conducted between 2018 and 2022. A large sample of pregnant women meeting specific eligibility criteria was included, while cases with potential confounders were excluded. Two-dimensional echocardiography with pulsed Doppler techniques was employed, focusing on the left ventricular inflow and outflow. Data were rigorously analyzed with careful assessment of measurements and normalization procedures.</p><p><strong>Results: </strong>In total, 1,309 echocardiograms were performed, and 1,183 pregnant women were included after applying the eligibility criteria. Detailed percentiles for each gestational age were determined, and a Z-score equation was formulated. A very weak correlation was observed between AV interval measurement and gestational age (r=0.16, P<0.001). In addition, the correlation between AV interval measurement and fetal heart rate was weak (r=-0.21, P<0.001). The Z-score for the AV interval measurement in milliseconds was derived as follows: Z-score=(AV interval measurement-111.3)/8.6.</p><p><strong>Conclusion: </strong>This study provides a reference range and Z-score equation for the AV interval, which may enhance the accuracy of monitoring fetuses at risk for developing atrioventricular block-especially in pregnant women with specific antibodies-thus facilitating earlier diagnosis and treatment.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"44 3","pages":"212-219"},"PeriodicalIF":2.4000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081140/pdf/","citationCount":"0","resultStr":"{\"title\":\"Development of a Z-score equation for atrioventricular interval measurement by two-dimensional pulsed Doppler echocardiography in normal fetuses between 16 and 33+6 weeks of gestation.\",\"authors\":\"Luciane Alves da Rocha Amorim, Nathalie Jeanne Bravo-Valenzuela, Sophia Livas de Morais Almeida, Alberto Borges Peixoto, Luiz Henrique Soares Nicoloso, Márcia Moura Schmidt, Paulo Zielinsky, Edward Araujo Júnior\",\"doi\":\"10.14366/usg.24142\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Fetal echocardiography is the primary diagnostic tool for assessing the atrioventricular (AV) time interval. Establishing a reference range for this parameter throughout pregnancy is essential for the early detection of potential abnormalities. The aim of this study was to develop a Z-score equation and establish specific percentiles for the AV time interval in normal fetuses between 16 and 33+6 weeks of gestation.</p><p><strong>Methods: </strong>A multicenter, prospective, cross-sectional study was conducted between 2018 and 2022. A large sample of pregnant women meeting specific eligibility criteria was included, while cases with potential confounders were excluded. Two-dimensional echocardiography with pulsed Doppler techniques was employed, focusing on the left ventricular inflow and outflow. Data were rigorously analyzed with careful assessment of measurements and normalization procedures.</p><p><strong>Results: </strong>In total, 1,309 echocardiograms were performed, and 1,183 pregnant women were included after applying the eligibility criteria. Detailed percentiles for each gestational age were determined, and a Z-score equation was formulated. A very weak correlation was observed between AV interval measurement and gestational age (r=0.16, P<0.001). In addition, the correlation between AV interval measurement and fetal heart rate was weak (r=-0.21, P<0.001). 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Development of a Z-score equation for atrioventricular interval measurement by two-dimensional pulsed Doppler echocardiography in normal fetuses between 16 and 33+6 weeks of gestation.
Purpose: Fetal echocardiography is the primary diagnostic tool for assessing the atrioventricular (AV) time interval. Establishing a reference range for this parameter throughout pregnancy is essential for the early detection of potential abnormalities. The aim of this study was to develop a Z-score equation and establish specific percentiles for the AV time interval in normal fetuses between 16 and 33+6 weeks of gestation.
Methods: A multicenter, prospective, cross-sectional study was conducted between 2018 and 2022. A large sample of pregnant women meeting specific eligibility criteria was included, while cases with potential confounders were excluded. Two-dimensional echocardiography with pulsed Doppler techniques was employed, focusing on the left ventricular inflow and outflow. Data were rigorously analyzed with careful assessment of measurements and normalization procedures.
Results: In total, 1,309 echocardiograms were performed, and 1,183 pregnant women were included after applying the eligibility criteria. Detailed percentiles for each gestational age were determined, and a Z-score equation was formulated. A very weak correlation was observed between AV interval measurement and gestational age (r=0.16, P<0.001). In addition, the correlation between AV interval measurement and fetal heart rate was weak (r=-0.21, P<0.001). The Z-score for the AV interval measurement in milliseconds was derived as follows: Z-score=(AV interval measurement-111.3)/8.6.
Conclusion: This study provides a reference range and Z-score equation for the AV interval, which may enhance the accuracy of monitoring fetuses at risk for developing atrioventricular block-especially in pregnant women with specific antibodies-thus facilitating earlier diagnosis and treatment.
UltrasonographyMedicine-Radiology, Nuclear Medicine and Imaging
CiteScore
5.10
自引率
6.50%
发文量
78
审稿时长
15 weeks
期刊介绍:
Ultrasonography, the official English-language journal of the Korean Society of Ultrasound in Medicine (KSUM), is an international peer-reviewed academic journal dedicated to practice, research, technology, and education dealing with medical ultrasound. It is renamed from the Journal of Korean Society of Ultrasound in Medicine in January 2014, and published four times per year: January 1, April 1, July 1, and October 1. Original articles, technical notes, topical reviews, perspectives, pictorial essays, and timely editorial materials are published in Ultrasonography covering state-of-the-art content.
Ultrasonography aims to provide updated information on new diagnostic concepts and technical developments, including experimental animal studies using new equipment in addition to well-designed reviews of contemporary issues in patient care. Along with running KSUM Open, the annual international congress of KSUM, Ultrasonography also serves as a medium for cooperation among physicians and specialists from around the world who are focusing on various ultrasound technology and disease problems and relevant basic science.