低密度中性粒细胞与其他免疫细胞在炎症机制中的相互作用。

IF 6 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Medicine Pub Date : 2025-04-09 DOI:10.1186/s10020-025-01187-5

Yu Fu, Zongmei Wen, Jie Fan

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引用次数: 0

摘要

低密度中性粒细胞（ldn）是中性粒细胞的一个独特亚群，在调节各种炎症相关疾病的先天免疫和适应性免疫中发挥重要作用。越来越多的证据表明，ldn在各种疾病的发病和进展中起着重要作用，包括感染、自身免疫性疾病和癌症。在这篇综述中，我们讨论了ldn的起源、发展和异质性，以及ldn在系统稳态和疾病中的作用。我们将重点关注ldn与其他免疫细胞之间相互作用的发现。然后，我们将讨论通过靶向ldn干预疾病的潜在新治疗策略。

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Interaction of low-density neutrophils with other immune cells in the mechanism of inflammation.

Low-density neutrophils (LDNs) are a unique subpopulation of neutrophils, play a significant role in regulating innate and adaptive immunity in various inflammation-related diseases. Emerging evidence suggests that LDNs play a significant role in the pathogenesis and progression of various diseases, including infections, autoimmune disorders, and cancer. In this review, we address the origin, development, and heterogeneity of LDNs, and the roles of LDNs in system homeostasis and diseases. We will focus on the findings of the interaction between LDNs and other immune cells. We will then discuss potential novel therapeutic strategies of intervention in diseases by targeting LDNs.

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来源期刊

Molecular Medicine 医学-生化与分子生物学

CiteScore

8.60

自引率

0.00%

发文量

137

审稿时长

1 months

期刊介绍： Molecular Medicine is an open access journal that focuses on publishing recent findings related to disease pathogenesis at the molecular or physiological level. These insights can potentially contribute to the development of specific tools for disease diagnosis, treatment, or prevention. The journal considers manuscripts that present material pertinent to the genetic, molecular, or cellular underpinnings of critical physiological or disease processes. Submissions to Molecular Medicine are expected to elucidate the broader implications of the research findings for human disease and medicine in a manner that is accessible to a wide audience.