基于间充质干细胞/基质细胞的骨关节炎治疗新策略:靶向巨噬细胞介导的炎症以恢复关节稳态。

IF 4.8 3区 医学 Q1 GENETICS & HEREDITY
María Jesús Araya-Sapag, Eliana Lara-Barba, Cynthia García-Guerrero, Yeimi Herrera-Luna, Yesenia Flores-Elías, Felipe A Bustamante-Barrientos, Guillermo G Albornoz, Consuelo Contreras-Fuentes, Liliana Yantén-Fuentes, Noymar Luque-Campos, Ana María Vega-Letter, Jorge Toledo, Patricia Luz-Crawford
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引用次数: 0

摘要

巨噬细胞在骨关节炎(OA)的发病机制中起着关键作用,因为它们的极化失调可能导致慢性炎症过程。本文探讨了影响巨噬细胞极化的分子和代谢机制,并确定了OA治疗的潜在策略。目前,骨关节炎的非手术治疗仅侧重于症状管理,其疗效有限;因此,间充质干细胞(MSCs)因其抗炎和免疫调节能力而受到关注。新出现的证据表明,来自MSCs的小细胞外囊泡(sev)可以调节巨噬细胞功能,从而为OA提供潜在的治疗益处。此外,线粒体从间充质干细胞转移到巨噬细胞已显示出增强线粒体功能和引导巨噬细胞向抗炎m2样表型的希望。虽然需要进一步的研究来证实这些发现,但基于msc的策略,包括使用sev和线粒体转移,对OA和其他慢性炎症性疾病的治疗有很大的希望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
New mesenchymal stem/stromal cell-based strategies for osteoarthritis treatment: targeting macrophage-mediated inflammation to restore joint homeostasis.

Macrophages are pivotal in osteoarthritis (OA) pathogenesis, as their dysregulated polarization can contribute to chronic inflammatory processes. This review explores the molecular and metabolic mechanisms that influence macrophage polarization and identifies potential strategies for OA treatment. Currently, non-surgical treatments for OA focus only on symptom management, and their efficacy is limited; thus, mesenchymal stem/stromal cells (MSCs) have gained attention for their anti-inflammatory and immunomodulatory capabilities. Emerging evidence suggests that small extracellular vesicles (sEVs) derived from MSCs can modulate macrophage function, thus offering potential therapeutic benefits in OA. Additionally, the transfer of mitochondria from MSCs to macrophages has shown promise in enhancing mitochondrial functionality and steering macrophages toward an anti-inflammatory M2-like phenotype. While further research is needed to confirm these findings, MSC-based strategies, including the use of sEVs and mitochondrial transfer, hold great promise for the treatment of OA and other chronic inflammatory diseases.

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来源期刊
Journal of Molecular Medicine-Jmm
Journal of Molecular Medicine-Jmm 医学-医学:研究与实验
CiteScore
9.30
自引率
0.00%
发文量
100
审稿时长
1.3 months
期刊介绍: The Journal of Molecular Medicine publishes original research articles and review articles that range from basic findings in mechanisms of disease pathogenesis to therapy. The focus includes all human diseases, including but not limited to: Aging, angiogenesis, autoimmune diseases as well as other inflammatory diseases, cancer, cardiovascular diseases, development and differentiation, endocrinology, gastrointestinal diseases and hepatology, genetics and epigenetics, hematology, hypoxia research, immunology, infectious diseases, metabolic disorders, neuroscience of diseases, -omics based disease research, regenerative medicine, and stem cell research. Studies solely based on cell lines will not be considered. Studies that are based on model organisms will be considered as long as they are directly relevant to human disease.
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