针对肺疾病APC的粘膜免疫治疗。

IF 4.4 3区 医学 Q2 IMMUNOLOGY
Yangqi Liu, Zijian Chen, Hanchang Cheng, Runzhi Zheng, Weizhe Huang
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引用次数: 0

摘要

几项研究表明,肺免疫反应主要是由抗原呈递细胞(APCs)促进的,专业和非专业APCs都有助于整体肺免疫。APCs在病原体消除和免疫调节中发挥着独特的作用和机制。与传统的肠外免疫相比,粘膜免疫表现出潜在的优势,因为它刺激粘膜和全身组织的免疫防御,这对减轻肺部疾病的负担很重要。然而,在各种肺部疾病的背景下,要全面了解粘膜免疫和APC之间的相互作用仍然具有挑战性。这篇综述旨在阐明新的粘膜免疫机制,针对APC在肺部感染、过敏和恶性肿瘤发生中的作用。这篇综述为各种肺部疾病更有效的治疗方法提供了重要的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mucosal immunotherapy targeting APC in lung disease.

Several studies have demonstrated that the pulmonary immune response is primarily facilitated by antigen-presenting cells (APCs), and that both professional and non-professional APCs contribute to overall pulmonary immunity. APCs play unique roles and mechanisms in pathogen elimination and immunomodulation. Mucosal immunity exhibits potential advantages over traditional parenteral immunity in that it stimulates immune defenses in mucosal and systemic tissues, which is important for reducing the burden of lung disease. However, obtaining a comprehensive understanding of the crosstalk between mucosal immunity and APC in the context of various lung diseases remains challenging. This mini-review aimed to elucidate the mechanisms of novel mucosal immunity, targeting APC action during lung infections, allergies, and malignant tumorigenesis. This minreview provides important insights into more effective therapeutic approaches for various lung diseases.

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来源期刊
CiteScore
7.90
自引率
0.00%
发文量
18
审稿时长
>12 weeks
期刊介绍: Journal of Inflammation welcomes research submissions on all aspects of inflammation. The five classical symptoms of inflammation, namely redness (rubor), swelling (tumour), heat (calor), pain (dolor) and loss of function (functio laesa), are only part of the story. The term inflammation is taken to include the full range of underlying cellular and molecular mechanisms involved, not only in the production of the inflammatory responses but, more importantly in clinical terms, in the healing process as well. Thus the journal covers molecular, cellular, animal and clinical studies, and related aspects of pharmacology, such as anti-inflammatory drug development, trials and therapeutic developments. It also considers publication of negative findings. Journal of Inflammation aims to become the leading online journal on inflammation and, as online journals replace printed ones over the next decade, the main open access inflammation journal. Open access guarantees a larger audience, and thus impact, than any restricted access equivalent, and increasingly so, as the escalating costs of printed journals puts them outside University budgets. The unrestricted access to research findings in inflammation aids in promoting dynamic and productive dialogue between industrial and academic members of the inflammation research community, which plays such an important part in the development of future generations of anti-inflammatory therapies.
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