Di-Ni Lin, Dan Li, Meng-Meng Peng, Hong Yang, Zhen-Zhen Lin, En-Ling Ye, Wen-Ting Chen, Meng-Xue Zhou, Xian-En Huang, Xue-Mian Lu
{"title":"腰臀比升高，作为腹部肥胖指数，预示着糖尿病肾损伤的风险。","authors":"Di-Ni Lin, Dan Li, Meng-Meng Peng, Hong Yang, Zhen-Zhen Lin, En-Ling Ye, Wen-Ting Chen, Meng-Xue Zhou, Xian-En Huang, Xue-Mian Lu","doi":"10.4239/wjd.v16.i4.101384","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Diabetic nephropathy (DN) is associated with a high incidence of type 2 diabetic mellitus (T2DM) in Asia. Central obesity is an important risk factor for DN, represented by a series of indices, including waist circumference, waist-to-hip ratio (WHR), hip circumference, and visceral to subcutaneous fat area ratio (VSR). However, limited research has focused on the association between these indices and DN.</p><p><strong>Aim: </strong>To elucidate the relationship between central fat distribution, as measured by WHR and VSR, and the DN progression.</p><p><strong>Methods: </strong>Between August 2018 and April 2023, a total of 991 individuals were retrospectively recruited from the Rui'an People's Hospital for this cross-sectional analysis. The 753 individuals with T2DM were divided into three groups according to the urinary albumin/creatinine ratio (ACR): normal albuminuria (<i>n</i> = 513, ACR < 30 mg/g), microalbuminuria (<i>n</i> = 166, 30 ≤ ACR < 300 mg/g), and clinical proteinuria (<i>n</i> = 45, ACR ≥ 300 mg/g).</p><p><strong>Results: </strong>Our results indicated that WHR and VSR were closely correlated with sex, ageing, body mass index, hypertension, T2DM causes, and experience of drinking and smoking, and potential relationships between these factors and DN progression were observed. WHR, but not VSR, gradually increased with the severity of early-stage renal injury. Abnormal serum lipid levels in T2DM patients with early-stage renal injury were strongly correlated with WHR. Logistic regression analysis revealed that WHR may be an independent risk factor for early-stage renal injury.</p><p><strong>Conclusion: </strong>In patients with T2DM, WHR level, rather than VSR level, is closely associated with early-stage renal injury. An abnormal serum lipid spectrum was common in all stages of renal injury and was strongly related to high WHR. Thus, WHR measurement might be a valuable tool for the early prevention of renal injury, which could guide clinical monitoring and prevent diabetic complications.</p>","PeriodicalId":48607,"journal":{"name":"World Journal of Diabetes","volume":"16 4","pages":"101384"},"PeriodicalIF":4.2000,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947918/pdf/","citationCount":"0","resultStr":"{\"title\":\"Elevated waist-to-hip ratio, as an abdominal obesity index, predicts the risk of diabetic kidney injury.\",\"authors\":\"Di-Ni Lin, Dan Li, Meng-Meng Peng, Hong Yang, Zhen-Zhen Lin, En-Ling Ye, Wen-Ting Chen, Meng-Xue Zhou, Xian-En Huang, Xue-Mian Lu\",\"doi\":\"10.4239/wjd.v16.i4.101384\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Diabetic nephropathy (DN) is associated with a high incidence of type 2 diabetic mellitus (T2DM) in Asia. Central obesity is an important risk factor for DN, represented by a series of indices, including waist circumference, waist-to-hip ratio (WHR), hip circumference, and visceral to subcutaneous fat area ratio (VSR). However, limited research has focused on the association between these indices and DN.</p><p><strong>Aim: </strong>To elucidate the relationship between central fat distribution, as measured by WHR and VSR, and the DN progression.</p><p><strong>Methods: </strong>Between August 2018 and April 2023, a total of 991 individuals were retrospectively recruited from the Rui'an People's Hospital for this cross-sectional analysis. The 753 individuals with T2DM were divided into three groups according to the urinary albumin/creatinine ratio (ACR): normal albuminuria (<i>n</i> = 513, ACR < 30 mg/g), microalbuminuria (<i>n</i> = 166, 30 ≤ ACR < 300 mg/g), and clinical proteinuria (<i>n</i> = 45, ACR ≥ 300 mg/g).</p><p><strong>Results: </strong>Our results indicated that WHR and VSR were closely correlated with sex, ageing, body mass index, hypertension, T2DM causes, and experience of drinking and smoking, and potential relationships between these factors and DN progression were observed. WHR, but not VSR, gradually increased with the severity of early-stage renal injury. Abnormal serum lipid levels in T2DM patients with early-stage renal injury were strongly correlated with WHR. Logistic regression analysis revealed that WHR may be an independent risk factor for early-stage renal injury.</p><p><strong>Conclusion: </strong>In patients with T2DM, WHR level, rather than VSR level, is closely associated with early-stage renal injury. An abnormal serum lipid spectrum was common in all stages of renal injury and was strongly related to high WHR. Thus, WHR measurement might be a valuable tool for the early prevention of renal injury, which could guide clinical monitoring and prevent diabetic complications.</p>\",\"PeriodicalId\":48607,\"journal\":{\"name\":\"World Journal of Diabetes\",\"volume\":\"16 4\",\"pages\":\"101384\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2025-04-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947918/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"World Journal of Diabetes\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4239/wjd.v16.i4.101384\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Journal of Diabetes","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4239/wjd.v16.i4.101384","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Elevated waist-to-hip ratio, as an abdominal obesity index, predicts the risk of diabetic kidney injury.
Background: Diabetic nephropathy (DN) is associated with a high incidence of type 2 diabetic mellitus (T2DM) in Asia. Central obesity is an important risk factor for DN, represented by a series of indices, including waist circumference, waist-to-hip ratio (WHR), hip circumference, and visceral to subcutaneous fat area ratio (VSR). However, limited research has focused on the association between these indices and DN.
Aim: To elucidate the relationship between central fat distribution, as measured by WHR and VSR, and the DN progression.
Methods: Between August 2018 and April 2023, a total of 991 individuals were retrospectively recruited from the Rui'an People's Hospital for this cross-sectional analysis. The 753 individuals with T2DM were divided into three groups according to the urinary albumin/creatinine ratio (ACR): normal albuminuria (n = 513, ACR < 30 mg/g), microalbuminuria (n = 166, 30 ≤ ACR < 300 mg/g), and clinical proteinuria (n = 45, ACR ≥ 300 mg/g).
Results: Our results indicated that WHR and VSR were closely correlated with sex, ageing, body mass index, hypertension, T2DM causes, and experience of drinking and smoking, and potential relationships between these factors and DN progression were observed. WHR, but not VSR, gradually increased with the severity of early-stage renal injury. Abnormal serum lipid levels in T2DM patients with early-stage renal injury were strongly correlated with WHR. Logistic regression analysis revealed that WHR may be an independent risk factor for early-stage renal injury.
Conclusion: In patients with T2DM, WHR level, rather than VSR level, is closely associated with early-stage renal injury. An abnormal serum lipid spectrum was common in all stages of renal injury and was strongly related to high WHR. Thus, WHR measurement might be a valuable tool for the early prevention of renal injury, which could guide clinical monitoring and prevent diabetic complications.
期刊介绍：
The WJD is a high-quality, peer reviewed, open-access journal. The primary task of WJD is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of diabetes. In order to promote productive academic communication, the peer review process for the WJD is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJD are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in diabetes. Scope: Diabetes Complications, Experimental Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes, Gestational, Diabetic Angiopathies, Diabetic Cardiomyopathies, Diabetic Coma, Diabetic Ketoacidosis, Diabetic Nephropathies, Diabetic Neuropathies, Donohue Syndrome, Fetal Macrosomia, and Prediabetic State.
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