Callan D Wesley, Jarl Emanuel Strange, Anders Holt, Gunnar H Gislason, Cédric H G Neutel, Dustin N Krüger, Celine Civati, Mart Theunis, Tania Naessens, Lynn Roth, Guido R Y De Meyer, Wim Martinet, Peter Vibe Rasmussen, Pieter-Jan Guns
{"title":"氟喹诺酮类药物与主动脉瘤或主动脉夹层的风险：来自全国巢式病例对照研究的证据，与匹配的实验模型平行。","authors":"Callan D Wesley, Jarl Emanuel Strange, Anders Holt, Gunnar H Gislason, Cédric H G Neutel, Dustin N Krüger, Celine Civati, Mart Theunis, Tania Naessens, Lynn Roth, Guido R Y De Meyer, Wim Martinet, Peter Vibe Rasmussen, Pieter-Jan Guns","doi":"10.1093/ehjopen/oeaf021","DOIUrl":null,"url":null,"abstract":"<p><strong>Aims: </strong>Fluoroquinolones (FQ) have been associated with aortic aneurysm and aortic dissection (AA/AD) resulting in an official warning. Recently, large-scale epidemiological studies failed to confirm this.</p><p><strong>Methods and results: </strong>The current study aimed to scrutinize the FQ-AA/AD association through a retrospective nested case-cohort analysis supplemented with animal experimentation. FQ exposure was not associated with increased AA/AD hazard ratios in main and high-risk (elderly ≥65 years, hypertensive, and prevalent aortic disease) populations. Additionally, FQ did not cause increased mortality or aortic interventions in aortic disease patients. In addition, in animal experimentation, ciprofloxacin did not enlarge aortic diameters nor increase arterial stiffness.</p><p><strong>Conclusion: </strong>Conventional use of FQ should not be avoided when clinically indicated.</p>","PeriodicalId":93995,"journal":{"name":"European heart journal open","volume":"5 3","pages":"oeaf021"},"PeriodicalIF":0.0000,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062879/pdf/","citationCount":"0","resultStr":"{\"title\":\"Fluoroquinolones and the risk of aortic aneurysm or aortic dissection: evidence from a nationwide nested case-control study paralleled with matched experimental models.\",\"authors\":\"Callan D Wesley, Jarl Emanuel Strange, Anders Holt, Gunnar H Gislason, Cédric H G Neutel, Dustin N Krüger, Celine Civati, Mart Theunis, Tania Naessens, Lynn Roth, Guido R Y De Meyer, Wim Martinet, Peter Vibe Rasmussen, Pieter-Jan Guns\",\"doi\":\"10.1093/ehjopen/oeaf021\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aims: </strong>Fluoroquinolones (FQ) have been associated with aortic aneurysm and aortic dissection (AA/AD) resulting in an official warning. Recently, large-scale epidemiological studies failed to confirm this.</p><p><strong>Methods and results: </strong>The current study aimed to scrutinize the FQ-AA/AD association through a retrospective nested case-cohort analysis supplemented with animal experimentation. FQ exposure was not associated with increased AA/AD hazard ratios in main and high-risk (elderly ≥65 years, hypertensive, and prevalent aortic disease) populations. Additionally, FQ did not cause increased mortality or aortic interventions in aortic disease patients. In addition, in animal experimentation, ciprofloxacin did not enlarge aortic diameters nor increase arterial stiffness.</p><p><strong>Conclusion: </strong>Conventional use of FQ should not be avoided when clinically indicated.</p>\",\"PeriodicalId\":93995,\"journal\":{\"name\":\"European heart journal open\",\"volume\":\"5 3\",\"pages\":\"oeaf021\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-03-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062879/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European heart journal open\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/ehjopen/oeaf021\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/5/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European heart journal open","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/ehjopen/oeaf021","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Fluoroquinolones and the risk of aortic aneurysm or aortic dissection: evidence from a nationwide nested case-control study paralleled with matched experimental models.
Aims: Fluoroquinolones (FQ) have been associated with aortic aneurysm and aortic dissection (AA/AD) resulting in an official warning. Recently, large-scale epidemiological studies failed to confirm this.
Methods and results: The current study aimed to scrutinize the FQ-AA/AD association through a retrospective nested case-cohort analysis supplemented with animal experimentation. FQ exposure was not associated with increased AA/AD hazard ratios in main and high-risk (elderly ≥65 years, hypertensive, and prevalent aortic disease) populations. Additionally, FQ did not cause increased mortality or aortic interventions in aortic disease patients. In addition, in animal experimentation, ciprofloxacin did not enlarge aortic diameters nor increase arterial stiffness.
Conclusion: Conventional use of FQ should not be avoided when clinically indicated.
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