{"title":"6-姜辣素对Wistar大鼠约束应激性损伤的心脏保护作用。","authors":"C Yang, A Zhang, H Chen, L Pan, J Li, J Wang","doi":"10.26402/jpp.2025.2.06","DOIUrl":null,"url":null,"abstract":"<p><p>Gingerol, the key active ingredient in ginger, is known for its numerous medicinal benefits. This research sought to explore, for the first time, Gingerol's potential to alleviate oxidative stress and apoptosis in the hearts of rats exposed to restraint stress (RS). Male albino rats were divided into four experimental groups, each comprising six rats: Group I (Control rats), Group II (Control rats given Gingerol), Group III (stressed rats) subjected to RS by being confined in restrainers for 2 hours daily for 21 days, and Group IV (stressed rats treated with Gingerol). After 21 days, the rats were sacrificed, and blood samples were taken via cardiac puncture for biochemical assays of lipid peroxidation (LPO), superoxide dismutase (SOD), reduced glutathione (GSH), and catalase (CAT). Heart tissues were meticulously collected for histological (hematoxylin and eosin staining) and biochemical assessments of oxidative stress and inflammation markers. Gingerol treatment in stressed rats enhanced their antioxidant defenses by decreasing LPO and increasing the levels of SOD, catalase CAT and GSH. Moreover, gingerol reduced the histopathological alterations caused by restraint stress in cardiac tissues, significantly lowering tumor necrosis factor-alpha (TNF-α), interleukin 1beta (IL-1β), and interleukin-6 (IL-6) levels. These results indicate that 6-Gingerol has antioxidant and anti-apoptotic effects, which can protect the rat heart against stress-induced oxidative damage.</p>","PeriodicalId":50089,"journal":{"name":"Journal of Physiology and Pharmacology","volume":"76 2","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cardioprotective effects of 6-gingerol on restraint stress-induced damage in Wistar rats.\",\"authors\":\"C Yang, A Zhang, H Chen, L Pan, J Li, J Wang\",\"doi\":\"10.26402/jpp.2025.2.06\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Gingerol, the key active ingredient in ginger, is known for its numerous medicinal benefits. This research sought to explore, for the first time, Gingerol's potential to alleviate oxidative stress and apoptosis in the hearts of rats exposed to restraint stress (RS). Male albino rats were divided into four experimental groups, each comprising six rats: Group I (Control rats), Group II (Control rats given Gingerol), Group III (stressed rats) subjected to RS by being confined in restrainers for 2 hours daily for 21 days, and Group IV (stressed rats treated with Gingerol). After 21 days, the rats were sacrificed, and blood samples were taken via cardiac puncture for biochemical assays of lipid peroxidation (LPO), superoxide dismutase (SOD), reduced glutathione (GSH), and catalase (CAT). Heart tissues were meticulously collected for histological (hematoxylin and eosin staining) and biochemical assessments of oxidative stress and inflammation markers. Gingerol treatment in stressed rats enhanced their antioxidant defenses by decreasing LPO and increasing the levels of SOD, catalase CAT and GSH. Moreover, gingerol reduced the histopathological alterations caused by restraint stress in cardiac tissues, significantly lowering tumor necrosis factor-alpha (TNF-α), interleukin 1beta (IL-1β), and interleukin-6 (IL-6) levels. These results indicate that 6-Gingerol has antioxidant and anti-apoptotic effects, which can protect the rat heart against stress-induced oxidative damage.</p>\",\"PeriodicalId\":50089,\"journal\":{\"name\":\"Journal of Physiology and Pharmacology\",\"volume\":\"76 2\",\"pages\":\"\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Physiology and Pharmacology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.26402/jpp.2025.2.06\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/5/5 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Physiology and Pharmacology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.26402/jpp.2025.2.06","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/5 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
Cardioprotective effects of 6-gingerol on restraint stress-induced damage in Wistar rats.
Gingerol, the key active ingredient in ginger, is known for its numerous medicinal benefits. This research sought to explore, for the first time, Gingerol's potential to alleviate oxidative stress and apoptosis in the hearts of rats exposed to restraint stress (RS). Male albino rats were divided into four experimental groups, each comprising six rats: Group I (Control rats), Group II (Control rats given Gingerol), Group III (stressed rats) subjected to RS by being confined in restrainers for 2 hours daily for 21 days, and Group IV (stressed rats treated with Gingerol). After 21 days, the rats were sacrificed, and blood samples were taken via cardiac puncture for biochemical assays of lipid peroxidation (LPO), superoxide dismutase (SOD), reduced glutathione (GSH), and catalase (CAT). Heart tissues were meticulously collected for histological (hematoxylin and eosin staining) and biochemical assessments of oxidative stress and inflammation markers. Gingerol treatment in stressed rats enhanced their antioxidant defenses by decreasing LPO and increasing the levels of SOD, catalase CAT and GSH. Moreover, gingerol reduced the histopathological alterations caused by restraint stress in cardiac tissues, significantly lowering tumor necrosis factor-alpha (TNF-α), interleukin 1beta (IL-1β), and interleukin-6 (IL-6) levels. These results indicate that 6-Gingerol has antioxidant and anti-apoptotic effects, which can protect the rat heart against stress-induced oxidative damage.
期刊介绍:
Journal of Physiology and Pharmacology publishes papers which fall within the range of basic and applied physiology, pathophysiology and pharmacology. The papers should illustrate new physiological or pharmacological mechanisms at the level of the cell membrane, single cells, tissues or organs. Clinical studies, that are of fundamental importance and have a direct bearing on the pathophysiology will also be considered. Letters related to articles published in The Journal with topics of general professional interest are welcome.