6-姜辣素对Wistar大鼠约束应激性损伤的心脏保护作用。

IF 2 4区 医学 Q3 PHYSIOLOGY
Journal of Physiology and Pharmacology Pub Date : 2025-04-01 Epub Date: 2025-05-05 DOI:10.26402/jpp.2025.2.06
C Yang, A Zhang, H Chen, L Pan, J Li, J Wang
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引用次数: 0

摘要

姜辣素是生姜的主要活性成分,因其众多的药用价值而闻名。本研究首次探讨了姜辣素在抑制应激(RS)大鼠心脏中减轻氧化应激和细胞凋亡的潜力。将雄性白化大鼠分为4个实验组,每组6只:ⅰ组(对照大鼠)、ⅱ组(给予姜辣素的对照大鼠)、ⅲ组(应激大鼠),每天在约束器中禁闭2小时,连续21 d,ⅳ组(给予姜辣素的应激大鼠)。21 d后处死大鼠,穿刺取血进行脂质过氧化(LPO)、超氧化物歧化酶(SOD)、还原性谷胱甘肽(GSH)、过氧化氢酶(CAT)生化检测。仔细收集心脏组织进行组织学(苏木精和伊红染色)和氧化应激和炎症标志物的生化评估。姜辣素通过降低应激大鼠LPO、提高SOD、过氧化氢酶CAT和GSH水平,增强应激大鼠抗氧化能力。姜辣素还能降低抑制应激引起的心脏组织病理改变,显著降低肿瘤坏死因子-α (TNF-α)、白细胞介素-1β (IL-1β)和白细胞介素-6 (IL-6)水平。结果表明,6-姜辣素具有抗氧化和抗凋亡作用,可保护大鼠心脏免受应激性氧化损伤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cardioprotective effects of 6-gingerol on restraint stress-induced damage in Wistar rats.

Gingerol, the key active ingredient in ginger, is known for its numerous medicinal benefits. This research sought to explore, for the first time, Gingerol's potential to alleviate oxidative stress and apoptosis in the hearts of rats exposed to restraint stress (RS). Male albino rats were divided into four experimental groups, each comprising six rats: Group I (Control rats), Group II (Control rats given Gingerol), Group III (stressed rats) subjected to RS by being confined in restrainers for 2 hours daily for 21 days, and Group IV (stressed rats treated with Gingerol). After 21 days, the rats were sacrificed, and blood samples were taken via cardiac puncture for biochemical assays of lipid peroxidation (LPO), superoxide dismutase (SOD), reduced glutathione (GSH), and catalase (CAT). Heart tissues were meticulously collected for histological (hematoxylin and eosin staining) and biochemical assessments of oxidative stress and inflammation markers. Gingerol treatment in stressed rats enhanced their antioxidant defenses by decreasing LPO and increasing the levels of SOD, catalase CAT and GSH. Moreover, gingerol reduced the histopathological alterations caused by restraint stress in cardiac tissues, significantly lowering tumor necrosis factor-alpha (TNF-α), interleukin 1beta (IL-1β), and interleukin-6 (IL-6) levels. These results indicate that 6-Gingerol has antioxidant and anti-apoptotic effects, which can protect the rat heart against stress-induced oxidative damage.

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来源期刊
CiteScore
4.00
自引率
22.70%
发文量
0
审稿时长
6-12 weeks
期刊介绍: Journal of Physiology and Pharmacology publishes papers which fall within the range of basic and applied physiology, pathophysiology and pharmacology. The papers should illustrate new physiological or pharmacological mechanisms at the level of the cell membrane, single cells, tissues or organs. Clinical studies, that are of fundamental importance and have a direct bearing on the pathophysiology will also be considered. Letters related to articles published in The Journal with topics of general professional interest are welcome.
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