Yi Teng, Jin Wu, Xin Cai, Weizhen Zhang, Kui Jiang, Hongfeng Zhou, Zhen Guo, Jiwei Liu, Yan Wang, Fang Liu, Shijie Lan, Hongxue Meng, Xiang Ji, Mei Xiang, Yongqi Li, Di Wu
{"title":"有创伤史的早期肢端黑色素瘤预后不良：468例患者的多中心分析。","authors":"Yi Teng, Jin Wu, Xin Cai, Weizhen Zhang, Kui Jiang, Hongfeng Zhou, Zhen Guo, Jiwei Liu, Yan Wang, Fang Liu, Shijie Lan, Hongxue Meng, Xiang Ji, Mei Xiang, Yongqi Li, Di Wu","doi":"10.1093/oncolo/oyaf086","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Previous studies have suggested that trauma may be a risk factor for the development and prognosis of acral melanoma (AM).</p><p><strong>Methods: </strong>This population-based retrospective cohort study included patients with AM and a confirmed history of trauma who received treatment at 5 melanoma treatment centers in China. Factors associated with recurrence and survival were analyzed using univariate and multivariate Cox regression analyses.</p><p><strong>Results: </strong>Totally 468 AM cases were included in this study, with 101 patients in the trauma group and 367 in the non-trauma group. The trauma group had more patients with ulceration (P = .027), mitotic rate ≥ 1 (P = .036), and Clark level IV-V (P = .009) than the non-trauma group. Among stage I-II postoperative AM patients, the median recurrence-free survival (RFS) was 33.3 months (95% CI: 18.8-47.8) and 115.6 months (95% CI: 96.3-135.0) in the trauma and non-trauma groups, respectively (P < .001). Similarly, the median overall survival (OS) was 64.6 (95% CI: 54.8-74.4) and not reached (95% CI: NR), respectively (P = .002). Comparatively, no significant differences were observed in RFS or OS between the trauma and non-trauma groups in patients with stage III and IV AM. Multifactorial analysis showed that trauma was an independent risk factor for RFS and OS only in patients with stage I-II AM patients.</p><p><strong>Conclusions: </strong>Postoperative stage I-II patients in the trauma group had significantly worse RFS and OS compared to those in the non-trauma group.</p>","PeriodicalId":54686,"journal":{"name":"Oncologist","volume":"30 5","pages":""},"PeriodicalIF":4.8000,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065939/pdf/","citationCount":"0","resultStr":"{\"title\":\"Poor prognosis of early-stage acral melanoma with a history of trauma: a multicenter analysis of 468 patients.\",\"authors\":\"Yi Teng, Jin Wu, Xin Cai, Weizhen Zhang, Kui Jiang, Hongfeng Zhou, Zhen Guo, Jiwei Liu, Yan Wang, Fang Liu, Shijie Lan, Hongxue Meng, Xiang Ji, Mei Xiang, Yongqi Li, Di Wu\",\"doi\":\"10.1093/oncolo/oyaf086\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Previous studies have suggested that trauma may be a risk factor for the development and prognosis of acral melanoma (AM).</p><p><strong>Methods: </strong>This population-based retrospective cohort study included patients with AM and a confirmed history of trauma who received treatment at 5 melanoma treatment centers in China. Factors associated with recurrence and survival were analyzed using univariate and multivariate Cox regression analyses.</p><p><strong>Results: </strong>Totally 468 AM cases were included in this study, with 101 patients in the trauma group and 367 in the non-trauma group. The trauma group had more patients with ulceration (P = .027), mitotic rate ≥ 1 (P = .036), and Clark level IV-V (P = .009) than the non-trauma group. Among stage I-II postoperative AM patients, the median recurrence-free survival (RFS) was 33.3 months (95% CI: 18.8-47.8) and 115.6 months (95% CI: 96.3-135.0) in the trauma and non-trauma groups, respectively (P < .001). Similarly, the median overall survival (OS) was 64.6 (95% CI: 54.8-74.4) and not reached (95% CI: NR), respectively (P = .002). Comparatively, no significant differences were observed in RFS or OS between the trauma and non-trauma groups in patients with stage III and IV AM. Multifactorial analysis showed that trauma was an independent risk factor for RFS and OS only in patients with stage I-II AM patients.</p><p><strong>Conclusions: </strong>Postoperative stage I-II patients in the trauma group had significantly worse RFS and OS compared to those in the non-trauma group.</p>\",\"PeriodicalId\":54686,\"journal\":{\"name\":\"Oncologist\",\"volume\":\"30 5\",\"pages\":\"\"},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2025-05-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065939/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oncologist\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/oncolo/oyaf086\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oncologist","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/oncolo/oyaf086","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}
Poor prognosis of early-stage acral melanoma with a history of trauma: a multicenter analysis of 468 patients.
Background: Previous studies have suggested that trauma may be a risk factor for the development and prognosis of acral melanoma (AM).
Methods: This population-based retrospective cohort study included patients with AM and a confirmed history of trauma who received treatment at 5 melanoma treatment centers in China. Factors associated with recurrence and survival were analyzed using univariate and multivariate Cox regression analyses.
Results: Totally 468 AM cases were included in this study, with 101 patients in the trauma group and 367 in the non-trauma group. The trauma group had more patients with ulceration (P = .027), mitotic rate ≥ 1 (P = .036), and Clark level IV-V (P = .009) than the non-trauma group. Among stage I-II postoperative AM patients, the median recurrence-free survival (RFS) was 33.3 months (95% CI: 18.8-47.8) and 115.6 months (95% CI: 96.3-135.0) in the trauma and non-trauma groups, respectively (P < .001). Similarly, the median overall survival (OS) was 64.6 (95% CI: 54.8-74.4) and not reached (95% CI: NR), respectively (P = .002). Comparatively, no significant differences were observed in RFS or OS between the trauma and non-trauma groups in patients with stage III and IV AM. Multifactorial analysis showed that trauma was an independent risk factor for RFS and OS only in patients with stage I-II AM patients.
Conclusions: Postoperative stage I-II patients in the trauma group had significantly worse RFS and OS compared to those in the non-trauma group.
期刊介绍：
The Oncologist® is dedicated to translating the latest research developments into the best multidimensional care for cancer patients. Thus, The Oncologist is committed to helping physicians excel in this ever-expanding environment through the publication of timely reviews, original studies, and commentaries on important developments. We believe that the practice of oncology requires both an understanding of a range of disciplines encompassing basic science related to cancer, translational research, and clinical practice, but also the socioeconomic and psychosocial factors that determine access to care and quality of life and function following cancer treatment.
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