{"title":"心房颤动和食管癌之间的因果关系：一项双样本孟德尔随机化研究。","authors":"Jinsong Lei, Longjun Yang, Gongming Wang, Qianwen Liu, Guangran Guo","doi":"10.21037/tcr-24-2107","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Previous studies indicated that atrial fibrillation (AF) patients had a significantly higher esophageal cancer (EC) risk. However, influencing by confounding factors, the causal effect is uncertain. In this study, we aimed to validate the causal relationship between AF and EC by Mendelian randomization (MR) analysis.</p><p><strong>Methods: </strong>An observational analysis was conducted using the data from the National Health and Nutrition Examination Survey (NHANES) and UK Biobank. Then a two-sample MR method was employed to assess the causal effect of AF on EC. The exposure of AF was collected from publicly available genome-wide association studies (GWASs). Meanwhile, the EC outcome data were derived from the UK Biobank and the FinnGen consortium. A set of 108 single-nucleotide polymorphisms (SNPs) served as instrumental variables (IVs). The effect estimates were calculated using the inverse variance weighted (IVW) method.</p><p><strong>Results: </strong>Genetically predicted AF was associated with an increased risk of EC [odds ratio (OR), 1.73; 95% confidence interval (CI): 1.01-1.73; P=0.04]. The similar results could be found by sensitivity analyses and no any evidence of horizontal pleiotropy was observed.</p><p><strong>Conclusions: </strong>This two-sample MR analysis suggested that AF was causally associated with an increased risk of EC.</p>","PeriodicalId":23216,"journal":{"name":"Translational cancer research","volume":"14 3","pages":"1849-1856"},"PeriodicalIF":1.5000,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11985194/pdf/","citationCount":"0","resultStr":"{\"title\":\"Causal associations between atrial fibrillation and esophageal cancer: a two-sample Mendelian randomization study.\",\"authors\":\"Jinsong Lei, Longjun Yang, Gongming Wang, Qianwen Liu, Guangran Guo\",\"doi\":\"10.21037/tcr-24-2107\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Previous studies indicated that atrial fibrillation (AF) patients had a significantly higher esophageal cancer (EC) risk. However, influencing by confounding factors, the causal effect is uncertain. In this study, we aimed to validate the causal relationship between AF and EC by Mendelian randomization (MR) analysis.</p><p><strong>Methods: </strong>An observational analysis was conducted using the data from the National Health and Nutrition Examination Survey (NHANES) and UK Biobank. Then a two-sample MR method was employed to assess the causal effect of AF on EC. The exposure of AF was collected from publicly available genome-wide association studies (GWASs). Meanwhile, the EC outcome data were derived from the UK Biobank and the FinnGen consortium. A set of 108 single-nucleotide polymorphisms (SNPs) served as instrumental variables (IVs). The effect estimates were calculated using the inverse variance weighted (IVW) method.</p><p><strong>Results: </strong>Genetically predicted AF was associated with an increased risk of EC [odds ratio (OR), 1.73; 95% confidence interval (CI): 1.01-1.73; P=0.04]. The similar results could be found by sensitivity analyses and no any evidence of horizontal pleiotropy was observed.</p><p><strong>Conclusions: </strong>This two-sample MR analysis suggested that AF was causally associated with an increased risk of EC.</p>\",\"PeriodicalId\":23216,\"journal\":{\"name\":\"Translational cancer research\",\"volume\":\"14 3\",\"pages\":\"1849-1856\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2025-03-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11985194/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Translational cancer research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.21037/tcr-24-2107\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/10 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational cancer research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.21037/tcr-24-2107","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/10 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
Causal associations between atrial fibrillation and esophageal cancer: a two-sample Mendelian randomization study.
Background: Previous studies indicated that atrial fibrillation (AF) patients had a significantly higher esophageal cancer (EC) risk. However, influencing by confounding factors, the causal effect is uncertain. In this study, we aimed to validate the causal relationship between AF and EC by Mendelian randomization (MR) analysis.
Methods: An observational analysis was conducted using the data from the National Health and Nutrition Examination Survey (NHANES) and UK Biobank. Then a two-sample MR method was employed to assess the causal effect of AF on EC. The exposure of AF was collected from publicly available genome-wide association studies (GWASs). Meanwhile, the EC outcome data were derived from the UK Biobank and the FinnGen consortium. A set of 108 single-nucleotide polymorphisms (SNPs) served as instrumental variables (IVs). The effect estimates were calculated using the inverse variance weighted (IVW) method.
Results: Genetically predicted AF was associated with an increased risk of EC [odds ratio (OR), 1.73; 95% confidence interval (CI): 1.01-1.73; P=0.04]. The similar results could be found by sensitivity analyses and no any evidence of horizontal pleiotropy was observed.
Conclusions: This two-sample MR analysis suggested that AF was causally associated with an increased risk of EC.
期刊介绍：
Translational Cancer Research (Transl Cancer Res TCR; Print ISSN: 2218-676X; Online ISSN 2219-6803; http://tcr.amegroups.com/) is an Open Access, peer-reviewed journal, indexed in Science Citation Index Expanded (SCIE). TCR publishes laboratory studies of novel therapeutic interventions as well as clinical trials which evaluate new treatment paradigms for cancer; results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of cancer patients. The focus of TCR is original, peer-reviewed, science-based research that successfully advances clinical medicine toward the goal of improving patients'' quality of life. The editors and an international advisory group of scientists and clinician-scientists as well as other experts will hold TCR articles to the high-quality standards. We accept Original Articles as well as Review Articles, Editorials and Brief Articles.
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