神经胶质瘤中的兴奋性环境：机制和治疗途径。

IF 13.4 1区医学 Q1 CLINICAL NEUROLOGY

Neuro-oncology Pub Date : 2025-09-17 DOI:10.1093/neuonc/noaf063

Bobak F Khalili, Karan Dixit, David O Kamson, Craig Horbinski, Delilah J Przybyla, Matthew C Tate, Amy B Heimberger, Rimas V Lukas, Jessica W Templer

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引用次数: 0

摘要

胶质瘤是最常见的原发性恶性脑肿瘤。它们的电生物学特性驱动疾病的发展，在某些肿瘤中，异常的神经信号传导是胶质瘤形成和胶质瘤相关性癫痫（GRE）的关键。肿瘤微管和神经胶质瘤突触是胶质瘤回路的组成部分。皮层高兴奋性病灶-胶质瘤周围-在疾病进展过程中发生严重改变，并受到基因突变、异常突触重塑、炎症变化和神经递质失衡的影响。这种病理机制已被用于抗癌和抗癫痫价值，其中一个子集仍有待探索。在这篇综述中，我们讨论了神经胶质瘤微环境中的过度兴奋条件以及癫痫发作和肿瘤控制的候选治疗方法。

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The excitatory milieu in glioma: Mechanisms and therapeutic avenues.

Gliomas are the most common primary malignant brain tumors. Their electrobiologic properties drive disease development, and in select tumors, aberrant neurosignaling is situated at the crux of gliomagenesis and glioma-related epilepsy. Tumor microtubes and the neuronal-glioma synapse are defined components of the glioma circuitry. The nidus of cortical hyperexcitability-the peri-glioma-undergoes severe alterations during disease progression and is influenced by genetic mutations, anomalous synaptic remodeling, inflammatory changes, and an imbalance in neurotransmitters. Such pathologic mechanisms have been exploited for anticancer and anti-seizure value wherein a subset remains to be explored. In this Review, we discuss the hyperexcitable conditions within the glioma microenvironment and candidate therapies for seizure and tumor control.

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来源期刊

Neuro-oncology 医学-临床神经学

CiteScore

27.20

自引率

6.30%

发文量

1434

审稿时长

3-8 weeks

期刊介绍： Neuro-Oncology, the official journal of the Society for Neuro-Oncology, has been published monthly since January 2010. Affiliated with the Japan Society for Neuro-Oncology and the European Association of Neuro-Oncology, it is a global leader in the field. The journal is committed to swiftly disseminating high-quality information across all areas of neuro-oncology. It features peer-reviewed articles, reviews, symposia on various topics, abstracts from annual meetings, and updates from neuro-oncology societies worldwide.