长期公开性脑室肥大在成人(LOVA)作为一个独特的实体在神经科医生的鉴别:叙述回顾。

IF 2.1 Q3 CLINICAL NEUROLOGY
BMJ Neurology Open Pub Date : 2025-05-01 eCollection Date: 2025-01-01 DOI:10.1136/bmjno-2024-001021
Racheed Mani, Jade Basem, Guy Schwartz, Michael Egnor
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引用次数: 0

摘要

成人长期公开性脑室肿大(LOVA)被认为是进行性脑积水的一种形式,与正常压力性脑积水(NPH)具有相似的临床和影像学特征,但应将其视为一种不同的临床实体。我们对LOVA作为一种独特的脑积水形式,具有其自身的临床和影像学特征以及治疗方式的文献进行了叙述性回顾分析。LOVA的特征是三脑室肿大,Evans'指数≥0.4,儿童期初始骤停后表现为颅内压升高的进行性症状,头围大于平均值≥2 SD。内镜下第三脑室造口术被认为是一线治疗。分流术同样有效,但并发症风险较高。LOVA是脑积水的一种进行性形式,具有一定的临床和影像学特征,与NPH重叠,但它是一个不同的实体,应该在神经科医生的鉴别上。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Long-standing overt ventriculomegaly in adults (LOVA) as a distinct entity on the neurologist's differential: a narrative review.

Long-standing overt ventriculomegaly in adults (LOVA) has been posited as a form of progressive hydrocephalus, with similar clinical and radiographic features to normal pressure hydrocephalus (NPH), but which should be understood as a distinct clinical entity. We conducted a narrative review analysing the literature into LOVA as a distinct form of hydrocephalus with its own clinical and radiographic characteristics and treatment modalities. LOVA is characterised by triventriculomegaly, an Evans' index of ≥0.4, presenting with progressive symptoms of elevated intracranial pressure after an initial arrest in childhood and head circumferences≥2 SD above the mean. Endoscopic third ventriculostomy is considered the first-line treatment. Shunting is equally effective but confers a higher complication risk profile. LOVA represents a progressive form of hydrocephalus with certain clinical and radiographic features which overlap with NPH, but is a distinct entity which should be on the neurologist's differential.

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来源期刊
BMJ Neurology Open
BMJ Neurology Open Medicine-Neurology (clinical)
CiteScore
3.20
自引率
3.70%
发文量
46
审稿时长
13 weeks
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