mettl3介导的脓毒症m6A修饰：当前证据和未来展望

IF 3 4区医学 Q2 GENETICS & HEREDITY

Epigenomics Pub Date : 2025-06-01 Epub Date: 2025-04-19 DOI:10.1080/17501911.2025.2494983

Zijun Wu, Changhong Miao, Hao Zhang

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引用次数: 0

摘要

脓毒症是一种由感染引发的严重全身性炎症，在世界范围内具有高发病率和高死亡率。虽然近年来医学诊断和治疗取得了进展，但仍然没有具体的治疗方法。近年来，表观遗传RNA修饰n6 -甲基腺苷（m6A）及其核心甲基转移酶METTL3的研究取得了重大进展。m6A在脓毒症中的作用也越来越被阐明。本文旨在探讨脓毒症的病理机制及其与m6A的关系，重点探讨m6A的关键基因METTL3在脓毒症中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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METTL3-mediated m6A modification in sepsis: current evidence and future perspectives.

Sepsis, a severe systemic inflammatory condition triggered by infection, is associated with high morbidity and mortality worldwide. While medical diagnosis and treatment have advanced in recent years, a specific therapy remains unavailable. Recently, significant progress has been made in studying the epigenetic RNA modification N6-methyladenosine (m6A) and its core methyltransferase METTL3. The role of m6A in sepsis has also been increasingly elucidated. This review aims to explore the pathological mechanisms of sepsis and its relationship with m6A, focusing on the role of the key m6A writer, METTL3, in sepsis.

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来源期刊

Epigenomics GENETICS & HEREDITY-

CiteScore

5.80

自引率

2.60%

发文量

审稿时长

>12 weeks

期刊介绍： Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community. Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.