An Tuan Huynh, Hoang Anh Vu, Ho Quoc Chuong, Tien Hoang Anh, An Viet Tran
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Despite growing interest, the specific contribution of MMP-2 polymorphisms to such damage in RH remains inadequately defined.</p><p><strong>Objective: </strong>This study is the first to examine the rs243865 (-1306C>T) polymorphism in the MMP-2 gene in the Vietnamese population and patients with RH, underscoring its critical role as a genetic determinant of TOD.</p><p><strong>Methods: </strong>A cross-sectional study with both descriptive and analytical components was conducted with 78 patients with RH at the Can Tho Central General Hospital and Can Tho University of Medicine and Pharmacy Hospital from July 2023 to February 2024.</p><p><strong>Results: </strong>More than three-quarters of patients with RH had carotid-femoral pulse wave velocity (PWV) >10 m/s and microalbuminuria at a prevalence of 79% (62/78) and 76% (59/78), respectively, and more than half of patients with RH had left ventricular mass index, relative wall thickness, and carotid artery stenosis with a prevalence of 56% (45/78), 55% (43/78), and 53% (41/78), respectively. Of the 78 studied patients with RH, the presence of genotype CC was 77% (60/78), genotype CT accounted for 21% (16/78), and genotype TT for 3% (2/78). The presence of single nucleotide polymorphism rs243865 (-1306C>T) with allele T was 23% (18/78). The MMP-2 gene polymorphism 1306C/T (rs243865) was significantly associated with ejection fraction and carotid artery stenosis with odds ratios (ORs) 8.1 (95% CI 1.3-51.4; P=.03) and 4.5 (95% CI 1.1-20.1; P=.048), respectively. The allele T was found to be significantly associated with arterial stiffness including brachial-ankle PWV and carotid-femoral PWV with the correlation coefficient of OR 2.2 (95% CI 0.6-3.8) and OR 1.8 (95% CI 0.5-3.2), respectively.</p><p><strong>Conclusions: </strong>The MMP-2 gene polymorphism rs243865 (-1306C>T) may have an association with measurable TOD in RH.</p>","PeriodicalId":14706,"journal":{"name":"JMIR Cardio","volume":"9 ","pages":"e71016"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061201/pdf/","citationCount":"0","resultStr":"{\"title\":\"The rs243865 Polymorphism in Matrix Metalloproteinase-2 and its Association With Target Organ Damage in Patients With Resistant Hypertension: Cross-Sectional Study.\",\"authors\":\"An Tuan Huynh, Hoang Anh Vu, Ho Quoc Chuong, Tien Hoang Anh, An Viet Tran\",\"doi\":\"10.2196/71016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Resistant hypertension (RH) presents significant clinical challenges, often precipitating a spectrum of cardiovascular complications. Particular attention recently has focused on the role of matrix metalloproteinase-2 (MMP-2) gene polymorphisms, implicated in hypertensive target organ damage (TOD). Despite growing interest, the specific contribution of MMP-2 polymorphisms to such damage in RH remains inadequately defined.</p><p><strong>Objective: </strong>This study is the first to examine the rs243865 (-1306C>T) polymorphism in the MMP-2 gene in the Vietnamese population and patients with RH, underscoring its critical role as a genetic determinant of TOD.</p><p><strong>Methods: </strong>A cross-sectional study with both descriptive and analytical components was conducted with 78 patients with RH at the Can Tho Central General Hospital and Can Tho University of Medicine and Pharmacy Hospital from July 2023 to February 2024.</p><p><strong>Results: </strong>More than three-quarters of patients with RH had carotid-femoral pulse wave velocity (PWV) >10 m/s and microalbuminuria at a prevalence of 79% (62/78) and 76% (59/78), respectively, and more than half of patients with RH had left ventricular mass index, relative wall thickness, and carotid artery stenosis with a prevalence of 56% (45/78), 55% (43/78), and 53% (41/78), respectively. Of the 78 studied patients with RH, the presence of genotype CC was 77% (60/78), genotype CT accounted for 21% (16/78), and genotype TT for 3% (2/78). The presence of single nucleotide polymorphism rs243865 (-1306C>T) with allele T was 23% (18/78). The MMP-2 gene polymorphism 1306C/T (rs243865) was significantly associated with ejection fraction and carotid artery stenosis with odds ratios (ORs) 8.1 (95% CI 1.3-51.4; P=.03) and 4.5 (95% CI 1.1-20.1; P=.048), respectively. The allele T was found to be significantly associated with arterial stiffness including brachial-ankle PWV and carotid-femoral PWV with the correlation coefficient of OR 2.2 (95% CI 0.6-3.8) and OR 1.8 (95% CI 0.5-3.2), respectively.</p><p><strong>Conclusions: </strong>The MMP-2 gene polymorphism rs243865 (-1306C>T) may have an association with measurable TOD in RH.</p>\",\"PeriodicalId\":14706,\"journal\":{\"name\":\"JMIR Cardio\",\"volume\":\"9 \",\"pages\":\"e71016\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061201/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JMIR Cardio\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2196/71016\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JMIR Cardio","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2196/71016","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
背景：顽固性高血压（RH）提出了重大的临床挑战，经常引发一系列心血管并发症。最近，人们特别关注基质金属蛋白酶-2 （MMP-2）基因多态性在高血压靶器官损伤（TOD）中的作用。尽管越来越多的人感兴趣，但MMP-2多态性对RH中这种损伤的具体贡献仍然没有充分的定义。目的：本研究首次在越南人群和RH患者中检测MMP-2基因rs243865 （-1306C>T）多态性，强调其作为TOD遗传决定因素的关键作用。方法：对2023年7月至2024年2月在芹苴中央总医院和芹苴药学院医院就诊的78例RH患者进行了描述性和分析性的横断面研究。结果：超过四分之三的RH患者存在颈股脉波速度（PWV） bbb10 m/s和微量白蛋白尿，患病率分别为79%（62/78）和76%(59/78)；超过一半的RH患者存在左室质量指数、相对壁厚和颈动脉狭窄，患病率分别为56%（45/78）、55%（43/78）和53%（41/78）。78例RH患者中，CC基因型占77% (60/78)，CT基因型占21% (16/78)，TT基因型占3%（2/78）。等位基因T的单核苷酸多态性rs243865 （-1306C>T）的存在率为23%（18/78）。MMP-2基因多态性1306C/T （rs243865）与射血分数和颈动脉狭窄显著相关，比值比（or） 8.1 (95% CI 1.3-51.4；P=.03)和4.5 (95% CI 1.1-20.1；分别P = .048)。发现等位基因T与动脉僵硬度显著相关，包括肱-踝PWV和颈-股PWV，相关系数分别为OR 2.2 （95% CI 0.6-3.8）和OR 1.8 （95% CI 0.5-3.2）。结论：MMP-2基因多态性rs243865 （-1306C>T）可能与RH中可测量的TOD有关。
The rs243865 Polymorphism in Matrix Metalloproteinase-2 and its Association With Target Organ Damage in Patients With Resistant Hypertension: Cross-Sectional Study.
Background: Resistant hypertension (RH) presents significant clinical challenges, often precipitating a spectrum of cardiovascular complications. Particular attention recently has focused on the role of matrix metalloproteinase-2 (MMP-2) gene polymorphisms, implicated in hypertensive target organ damage (TOD). Despite growing interest, the specific contribution of MMP-2 polymorphisms to such damage in RH remains inadequately defined.
Objective: This study is the first to examine the rs243865 (-1306C>T) polymorphism in the MMP-2 gene in the Vietnamese population and patients with RH, underscoring its critical role as a genetic determinant of TOD.
Methods: A cross-sectional study with both descriptive and analytical components was conducted with 78 patients with RH at the Can Tho Central General Hospital and Can Tho University of Medicine and Pharmacy Hospital from July 2023 to February 2024.
Results: More than three-quarters of patients with RH had carotid-femoral pulse wave velocity (PWV) >10 m/s and microalbuminuria at a prevalence of 79% (62/78) and 76% (59/78), respectively, and more than half of patients with RH had left ventricular mass index, relative wall thickness, and carotid artery stenosis with a prevalence of 56% (45/78), 55% (43/78), and 53% (41/78), respectively. Of the 78 studied patients with RH, the presence of genotype CC was 77% (60/78), genotype CT accounted for 21% (16/78), and genotype TT for 3% (2/78). The presence of single nucleotide polymorphism rs243865 (-1306C>T) with allele T was 23% (18/78). The MMP-2 gene polymorphism 1306C/T (rs243865) was significantly associated with ejection fraction and carotid artery stenosis with odds ratios (ORs) 8.1 (95% CI 1.3-51.4; P=.03) and 4.5 (95% CI 1.1-20.1; P=.048), respectively. The allele T was found to be significantly associated with arterial stiffness including brachial-ankle PWV and carotid-femoral PWV with the correlation coefficient of OR 2.2 (95% CI 0.6-3.8) and OR 1.8 (95% CI 0.5-3.2), respectively.
Conclusions: The MMP-2 gene polymorphism rs243865 (-1306C>T) may have an association with measurable TOD in RH.
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