S Shojaei-Zarghani, K Gorgi, A Bananzadeh, A R Safarpour, S V Hosseini
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Studies were eligible if they assessed bowel dysfunction using the LARS score and HRQOL using the European Organization for Research and Treatment Core Quality-of-Life Questionnaire (EORTC QLQ-C30).</p><p><strong>Results: </strong>Of 1410 reports, 28 studies were included. According to the analyses, patients with major LARS had lower global health status [weighted mean differences (WMD) = - 10.98; 95% confidence interval (CI) - 13.18, - 8.79], physical functioning (WMD = - 5.96; 95% CI - 7.40, - 4.52), role functioning (WMD = - 10.59; 95% CI - 12.54, - 8.63), emotional functioning (WMD = - 11.09; 95% CI - 14.34, 7.84), cognitive functioning (WMD = - 9.27; 95% CI - 12.22, - 6.32), and social functioning (WMD = - 15.73; 95% CI - 18.82, - 12.63) and higher scores of symptoms compared to patients with minor/no LARS.</p><p><strong>Conclusions: </strong>The study findings suggest that patients with major LARS experience worse HRQOL compared to those with minor/no LARS.</p><p><strong>Registration: </strong>PROSPERO, CRD42023479657.</p>","PeriodicalId":51192,"journal":{"name":"Techniques in Coloproctology","volume":"29 1","pages":"114"},"PeriodicalIF":2.9000,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065725/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effects of low anterior resection syndrome after colorectal cancer resections on health-related quality of life: a systematic review and meta-analysis.\",\"authors\":\"S Shojaei-Zarghani, K Gorgi, A Bananzadeh, A R Safarpour, S V Hosseini\",\"doi\":\"10.1007/s10151-025-03136-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Low anterior resection syndrome (LARS) is a term that encompasses multidimensional bowel dysfunction that typically occurs following resections of rectum and distal parts of the colon. We aimed to systematically assess the available literature on the effects of bowel dysfunction after colorectal cancer (CRC) surgeries on health-related quality of life (HRQOL) and conduct a meta-analysis.</p><p><strong>Methods: </strong>Studies were included if they assessed patients who had undergone sphincter-preservation surgeries for CRC. Studies were eligible if they assessed bowel dysfunction using the LARS score and HRQOL using the European Organization for Research and Treatment Core Quality-of-Life Questionnaire (EORTC QLQ-C30).</p><p><strong>Results: </strong>Of 1410 reports, 28 studies were included. 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引用次数: 0
摘要
背景：低位前切除术综合征（LARS）是一个包含多维度肠功能障碍的术语，通常发生在直肠和结肠远端切除术后。我们的目的是系统评估结肠直肠癌（CRC）手术后肠功能障碍对健康相关生活质量（HRQOL）影响的现有文献，并进行荟萃分析。方法：研究纳入了接受过保留括约肌手术的CRC患者。如果研究使用LARS评分评估肠功能障碍，使用欧洲研究和治疗组织核心生活质量问卷（EORTC QLQ-C30）评估HRQOL，则该研究符合条件。结果：在1410份报告中，纳入了28项研究。根据分析，重度LARS患者的整体健康状况较低[加权平均差(WMD) = - 10.98；95%置信区间(CI) - 13.18, - 8.79]，身体功能(WMD = - 5.96；95% CI - 7.40, - 4.52)，角色功能(WMD = - 10.59；95% CI - 12.54, - 8.63)，情绪功能(WMD = - 11.09；95% CI - 14.34, 7.84)，认知功能(WMD = - 9.27；95% CI - 12.22, - 6.32)和社会功能(WMD = - 15.73；95% CI - 18.82, - 12.63)，症状评分高于轻度/无LARS患者。结论：研究结果表明，重度LARS患者的HRQOL较轻度/无LARS患者差。报名：普洛斯彼罗，CRD42023479657。
Effects of low anterior resection syndrome after colorectal cancer resections on health-related quality of life: a systematic review and meta-analysis.
Background: Low anterior resection syndrome (LARS) is a term that encompasses multidimensional bowel dysfunction that typically occurs following resections of rectum and distal parts of the colon. We aimed to systematically assess the available literature on the effects of bowel dysfunction after colorectal cancer (CRC) surgeries on health-related quality of life (HRQOL) and conduct a meta-analysis.
Methods: Studies were included if they assessed patients who had undergone sphincter-preservation surgeries for CRC. Studies were eligible if they assessed bowel dysfunction using the LARS score and HRQOL using the European Organization for Research and Treatment Core Quality-of-Life Questionnaire (EORTC QLQ-C30).
Results: Of 1410 reports, 28 studies were included. According to the analyses, patients with major LARS had lower global health status [weighted mean differences (WMD) = - 10.98; 95% confidence interval (CI) - 13.18, - 8.79], physical functioning (WMD = - 5.96; 95% CI - 7.40, - 4.52), role functioning (WMD = - 10.59; 95% CI - 12.54, - 8.63), emotional functioning (WMD = - 11.09; 95% CI - 14.34, 7.84), cognitive functioning (WMD = - 9.27; 95% CI - 12.22, - 6.32), and social functioning (WMD = - 15.73; 95% CI - 18.82, - 12.63) and higher scores of symptoms compared to patients with minor/no LARS.
Conclusions: The study findings suggest that patients with major LARS experience worse HRQOL compared to those with minor/no LARS.
期刊介绍：
Techniques in Coloproctology is an international journal fully devoted to diagnostic and operative procedures carried out in the management of colorectal diseases. Imaging, clinical physiology, laparoscopy, open abdominal surgery and proctoperineology are the main topics covered by the journal. Reviews, original articles, technical notes and short communications with many detailed illustrations render this publication indispensable for coloproctologists and related specialists. Both surgeons and gastroenterologists are represented on the distinguished Editorial Board, together with pathologists, radiologists and basic scientists from all over the world. The journal is strongly recommended to those who wish to be updated on recent developments in the field, and improve the standards of their work.
Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1965 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted. Reports of animal experiments must state that the Principles of Laboratory Animal Care (NIH publication no. 86-23 revised 1985) were followed as were applicable national laws (e.g. the current version of the German Law on the Protection of Animals). The Editor-in-Chief reserves the right to reject manuscripts that do not comply with the above-mentioned requirements. Authors will be held responsible for false statements or for failure to fulfill such requirements.
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