多通道经颅直流电刺激脑卒中患者同侧初级运动皮层和顶叶前沟后静息状态血流动力学变化及其对上肢功能的影响:一项fNIRS的初步研究。

IF 5.2 2区 医学 Q1 ENGINEERING, BIOMEDICAL
Seung Hyun Lee, Gihyoun Lee, Jinuk Kim, Zephaniah Phillips V, Heegoo Kim, Eunmi Kim, Su-Hyun Lee, Ho Choon Jeong, Seung-Ho Paik, Yun-Hee Kim, Beop-Min Kim
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引用次数: 0

摘要

背景:脑卒中导致大量的长期残疾,需要有效的康复干预。本研究探讨多通道经颅直流电刺激(tDCS)对脑卒中患者血流动力学反应和上肢运动功能的影响,以同侧原发性运动皮质(M1)和顶叶前沟(aIPS)为靶点。方法:对24例脑卒中患者进行双盲、随机、假对照试验(男性18例;平均年龄,57.3×14.2岁),他们接受了10次真实或虚假的多通道tDCS联合上肢运动。功能近红外光谱(fNIRS)测量静息状态脑血流动力学反应在每次会议前后5分钟。在干预前后,采用Fugl-Meyer上肢运动功能评估(FMA-UE)、盒块测试(BBT)和其他运动功能测试来评估运动功能。结果:真正的多通道tDCS组表现出刺激后运动皮层内氧合血红蛋白(HbOAcc)的区域积累增加和更强的种子连接网络。相反,假手术组表现出与这些区域的分离。盒块测试(BBT)的组×时间交互作用是显著的,表明与假手术组相比,真实tdcs组的总手灵巧性有更大的改善。虽然HbOAcc的刺激后变化与FMA-UE评分的关系被检查,但在真实tdcs组中没有观察到强的线性关系。结论:针对同侧M1和aIPS的多通道tDCS联合上肢运动对脑卒中患者的脑血流动力学和运动功能有潜在影响。以上结果提示,多通道tDCS可能在运动康复中发挥作用,但其疗效和临床适用性有待进一步研究验证。临床试验:GOV:本研究已在Clinicaltrials . GOV注册(NCT05275114)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Resting-state hemodynamic changes and effects on upper limb function after multi-channel transcranial direct current stimulation to the ipsilesional primary motor cortex and anterior intraparietal sulcus in stroke patients: an fNIRS pilot study.

Background: Stroke results in substantial long-term disability, necessitating effective recovery interventions. This study explored the effects of multi-channel transcranial direct current stimulation (tDCS) on hemodynamic responses and upper limb motor function in stroke patients, targeting the ipsilesional primary motor cortex (M1) and anterior intraparietal sulcus (aIPS).

Methods: A double-blind, randomized, sham-controlled trial was conducted with 24 stroke patients (18 men; mean age, 57.3×14.2 years), who underwent 10 sessions of real or sham multi-channel tDCS combined with upper limb exercises. Functional near-infrared spectroscopy (fNIRS) measured resting-state cerebral hemodynamic responses for 5 min before and after each session. Motor function was evaluated using the Fugl-Meyer assessment for upper extremity (FMA-UE), box and block test (BBT), and other motor function tests before and after the interventions.

Results: The real multi-channel tDCS group exhibited increases in regional accumulation of oxyhemoglobin (HbOAcc) and stronger seeded connectivity networks within the motor cortex poststimulation. In contrast, the sham group exhibited disassociation from these areas. The group × time interaction was significant for the Box and Block Test (BBT), indicating greater improvements in gross manual dexterity in the real-tDCS group compared to the sham group. While poststimulation changes in HbOAcc were examined in relation to FMA-UE scores, no strong linear relationship was observed in the real-tDCS group.

Conclusions: Multi-channel tDCS targeting the ipsilesional M1 and aIPS, combined with upper limb exercises, showed potential effects on cerebral hemodynamics and motor function in stroke patients. These findings suggest that multi-channel tDCS may have a role in motor rehabilitation, but further research is needed to validate its efficacy and clinical applicability.

Clinicaltrials: GOV: This study was registered at ClinicalTrials.gov (NCT05275114).

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来源期刊
Journal of NeuroEngineering and Rehabilitation
Journal of NeuroEngineering and Rehabilitation 工程技术-工程:生物医学
CiteScore
9.60
自引率
3.90%
发文量
122
审稿时长
24 months
期刊介绍: Journal of NeuroEngineering and Rehabilitation considers manuscripts on all aspects of research that result from cross-fertilization of the fields of neuroscience, biomedical engineering, and physical medicine & rehabilitation.
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