经颅磁共振成像引导聚焦超声治疗神经性疼痛。

IF 2.7
Expert review of medical devices Pub Date : 2025-05-01 Epub Date: 2025-05-07 DOI:10.1080/17434440.2025.2485289
Silvia Marino, Maria Le Cause, Simona De Salvo, Luigi Cardia, Francesco Corallo, Carmelo Anfuso, Giuseppe Di Lorenzo, Rosa Morabito, Simona Cammaroto, Chiara Smorto, Annalisa Militi, Chiara Sorbera, Amelia Brigandì, Rosario Maugeri, Angelo Lavano, Angelo Quartarore, Domenico La Torre
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引用次数: 0

摘要

磁共振成像引导聚焦超声(MRgFUS)在各种神经系统疾病,包括运动障碍,脑肿瘤和退行性疾病中显示出有希望的结果。最近的临床试验表明,MRgFUS可以产生治疗原发性震颤(ET)和帕金森病(PD)的效果,与其他神经外科干预措施的效果相当。此外,人们越来越关注FUS技术的发展及其临床应用,旨在探索新的用途并加强现有的用途。涵盖领域:在本综述中,在多个平台上进行了全面的搜索,包括PubMed、Scopus和Cochrane图书馆。筛选包括基于出版年份的研究和涉及人类受试者的临床试验(不包括动物研究)。对结果进行彻底的分析对于实现我们的研究目标至关重要。虽然一些研究仍在等待结果,但它们显示出了希望;其他项目已经完成。专家意见:作者特别选择了六项研究,取得了优异的结果,涵盖了治疗副作用、疼痛部位、关键发现、超声温度和样本量等方面。这篇综述的目的是提供关于MRgFUS在神经性疼痛治疗中的应用的最新文献和正在进行的临床试验的概述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Transcranial magnetic resonance imaging-guided focused ultrasound for neuropathic pain treatment.

Introduction: Magnetic resonance imaging-guided focused ultrasound (MRgFUS) has shown promising results for a variety of neurological conditions, including movement disorders, brain tumors, and degenerative diseases. Recent clinical trials have demonstrated that MRgFUS can produce therapeutic effects in essential tremor (ET) and Parkinson's disease (PD), comparable to those achieved with other neurosurgical interventions. Furthermore, there has been increasing attention on the development of FUS technology and its clinical applications, aimed at exploring new uses and enhancing existing ones.

Areas covered: In this review, a comprehensive search was conducted across multiple platforms, including PubMed, Scopus, and the Cochrane Library. Filters were applied to include studies based on publication year and clinical trials involving human subjects (excluding animal studies). A thorough analysis of the results was crucial for achieving the objectives of our research. While some studies are still awaiting results, they show promise; others have already been completed.

Expert opinion: The authors specifically selected six studies that yielded excellent results, covering aspects such as treatment side effects, pain location, key findings, ultrasound temperature, and sample size. he aim of this review is to provide an overview of the recent literature and ongoing clinical trials regarding the application of MRgFUS in the treatment of neuropathic pain.

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