揭示Wnt通路在肝细胞癌中的作用：从分子机制到治疗意义

IF 3.1 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Journal of Clinical and Translational Hepatology Pub Date : 2025-04-28 Epub Date: 2025-01-14 DOI:10.14218/JCTH.2024.00401

Zixin Liang, Shanshan Li, Zhiyu Wang, Junting Zhou, Ziyue Huang, Jiehan Li, Haolin Bao, Judy Wai Ping Yam, Yi Xu

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引用次数: 0

摘要

肝细胞癌（HCC）是世界上最致命的恶性肿瘤之一，其发病率和死亡率逐年上升。HCC的研究越来越集中于了解其发病机制和开发治疗方法。Wnt信号通路是一个复杂且进化保守的信号转导系统，在多种恶性肿瘤的发生和治疗中得到了广泛的研究。最近的研究表明，HCC的发病机制可能受到Wnt/β-catenin信号失调的显著影响。本文旨在探讨肝癌中控制Wnt信号通路及其机制。此外，我们强调了该通路在HCC病因学和靶向治疗中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Unraveling the Role of the Wnt Pathway in Hepatocellular Carcinoma: From Molecular Mechanisms to Therapeutic Implications.

Hepatocellular carcinoma (HCC) is one of the deadliest malignant tumors in the world, and its incidence and mortality have increased year by year. HCC research has increasingly focused on understanding its pathogenesis and developing treatments.The Wnt signaling pathway, a complex and evolutionarily conserved signal transduction system, has been extensively studied in the genesis and treatment of several malignant tumors. Recent investigations suggest that the pathogenesis of HCC may be significantly influenced by dysregulated Wnt/β-catenin signaling. This article aimed to examine the pathway that controls Wnt signaling in HCC and its mechanisms. In addition, we highlighted the role of this pathway in HCC etiology and targeted treatment.

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来源期刊

Journal of Clinical and Translational Hepatology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

6.40

自引率

2.80%

发文量

496