Allison L B Shapiro, Phoom Narongkiatikhun, Ye Ji Choi, Greta Wilkening, Kalie L Tommerdahl, Hailey E Hamson, Laura Pyle, Petter Bjornstad
{"title":"青少年发病2型糖尿病的脑功能和结构改变。","authors":"Allison L B Shapiro, Phoom Narongkiatikhun, Ye Ji Choi, Greta Wilkening, Kalie L Tommerdahl, Hailey E Hamson, Laura Pyle, Petter Bjornstad","doi":"10.1093/ejendo/lvaf098","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Despite the aggressive clinical trajectory of youth-onset type 2 diabetes (Y-T2D) and consistent evidence of cognitive dysfunction and poor brain health in adults with T2D, the impact of Y-T2D on brain function and structure is understudied.</p><p><strong>Design: </strong>This study aimed to characterize brain function and structure in a cross-sectional sample of young people with Y-T2D and compare these brain attributes to peers with obesity alone (OB) or healthy weight (HW) without T2D.</p><p><strong>Methods: </strong>Brain structure and function were measured via magnetic resonance imaging. Functional connectivity was estimated with a seed-to-voxel analysis and gray matter (GM) volume differences explored between groups.</p><p><strong>Results: </strong>Forty young adult participants were included (Y-T2D: n = 12, mean [±SD] age 25.0 ± 7.2 years, diabetes duration 6.5 ± 6.7 years; OB: n = 8, age 19 ± 1.6 years; HW: n = 20, age 22.9 ± 4.1 years). The Y-T2D group showed stronger functional connectivity between the salience network and default mode network, compared to both the OB and HW groups (P < .05 for all, respectively). The Y-T2D group had reduced GM volume in regions associated with executive functioning, language, and visual processing relative to the OB and HW groups (P < .001 for all, respectively).</p><p><strong>Conclusions: </strong>Y-T2D is associated with distinct alterations in brain function and structure, providing evidence of potentially compromised brain health in this clinical population.</p>","PeriodicalId":11884,"journal":{"name":"European Journal of Endocrinology","volume":" ","pages":"671-679"},"PeriodicalIF":5.3000,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100494/pdf/","citationCount":"0","resultStr":"{\"title\":\"Altered brain function and structure in youth-onset type 2 diabetes.\",\"authors\":\"Allison L B Shapiro, Phoom Narongkiatikhun, Ye Ji Choi, Greta Wilkening, Kalie L Tommerdahl, Hailey E Hamson, Laura Pyle, Petter Bjornstad\",\"doi\":\"10.1093/ejendo/lvaf098\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Despite the aggressive clinical trajectory of youth-onset type 2 diabetes (Y-T2D) and consistent evidence of cognitive dysfunction and poor brain health in adults with T2D, the impact of Y-T2D on brain function and structure is understudied.</p><p><strong>Design: </strong>This study aimed to characterize brain function and structure in a cross-sectional sample of young people with Y-T2D and compare these brain attributes to peers with obesity alone (OB) or healthy weight (HW) without T2D.</p><p><strong>Methods: </strong>Brain structure and function were measured via magnetic resonance imaging. Functional connectivity was estimated with a seed-to-voxel analysis and gray matter (GM) volume differences explored between groups.</p><p><strong>Results: </strong>Forty young adult participants were included (Y-T2D: n = 12, mean [±SD] age 25.0 ± 7.2 years, diabetes duration 6.5 ± 6.7 years; OB: n = 8, age 19 ± 1.6 years; HW: n = 20, age 22.9 ± 4.1 years). The Y-T2D group showed stronger functional connectivity between the salience network and default mode network, compared to both the OB and HW groups (P < .05 for all, respectively). The Y-T2D group had reduced GM volume in regions associated with executive functioning, language, and visual processing relative to the OB and HW groups (P < .001 for all, respectively).</p><p><strong>Conclusions: </strong>Y-T2D is associated with distinct alterations in brain function and structure, providing evidence of potentially compromised brain health in this clinical population.</p>\",\"PeriodicalId\":11884,\"journal\":{\"name\":\"European Journal of Endocrinology\",\"volume\":\" \",\"pages\":\"671-679\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2025-04-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100494/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Endocrinology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/ejendo/lvaf098\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Endocrinology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/ejendo/lvaf098","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Altered brain function and structure in youth-onset type 2 diabetes.
Objective: Despite the aggressive clinical trajectory of youth-onset type 2 diabetes (Y-T2D) and consistent evidence of cognitive dysfunction and poor brain health in adults with T2D, the impact of Y-T2D on brain function and structure is understudied.
Design: This study aimed to characterize brain function and structure in a cross-sectional sample of young people with Y-T2D and compare these brain attributes to peers with obesity alone (OB) or healthy weight (HW) without T2D.
Methods: Brain structure and function were measured via magnetic resonance imaging. Functional connectivity was estimated with a seed-to-voxel analysis and gray matter (GM) volume differences explored between groups.
Results: Forty young adult participants were included (Y-T2D: n = 12, mean [±SD] age 25.0 ± 7.2 years, diabetes duration 6.5 ± 6.7 years; OB: n = 8, age 19 ± 1.6 years; HW: n = 20, age 22.9 ± 4.1 years). The Y-T2D group showed stronger functional connectivity between the salience network and default mode network, compared to both the OB and HW groups (P < .05 for all, respectively). The Y-T2D group had reduced GM volume in regions associated with executive functioning, language, and visual processing relative to the OB and HW groups (P < .001 for all, respectively).
Conclusions: Y-T2D is associated with distinct alterations in brain function and structure, providing evidence of potentially compromised brain health in this clinical population.
期刊介绍:
European Journal of Endocrinology is the official journal of the European Society of Endocrinology. Its predecessor journal is Acta Endocrinologica.
The journal publishes high-quality original clinical and translational research papers and reviews in paediatric and adult endocrinology, as well as clinical practice guidelines, position statements and debates. Case reports will only be considered if they represent exceptional insights or advances in clinical endocrinology.
Topics covered include, but are not limited to, Adrenal and Steroid, Bone and Mineral Metabolism, Hormones and Cancer, Pituitary and Hypothalamus, Thyroid and Reproduction. In the field of Diabetes, Obesity and Metabolism we welcome manuscripts addressing endocrine mechanisms of disease and its complications, management of obesity/diabetes in the context of other endocrine conditions, or aspects of complex disease management. Reports may encompass natural history studies, mechanistic studies, or clinical trials.
Equal consideration is given to all manuscripts in English from any country.