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引用次数: 0
摘要
虽然嵌合抗原受体（CAR） t细胞疗法已经彻底改变了淋巴细胞恶性肿瘤的治疗前景，但其最大的挑战仍然是急性髓性白血病（AML）的治疗。它在AML中的成功一直受到理想靶抗原、骨髓抑制和免疫抑制白血病微环境的限制。2024年ASH会议强调了aml靶向CAR - T疗法的几个前沿进展，包括针对CD33、CD123、CLL1、CD19和IL1RAP的临床试验，以及新的工程策略，如双靶向CAR、抑制性CAR设计和基因组编辑方法，以提高安全性和有效性。在这里，我们总结了临床和临床前研究的关键发现，为AML CAR - t细胞治疗的发展前景提供了见解。
Breakthroughs of CAR T-cell therapy in acute myeloid leukemia: updates from ASH 2024.
While chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment landscape for lymphoid malignancies, its greatest challenge remains in the treatment of acute myeloid leukemia (AML). Its success in AML has been limited by the ideal target antigen, myelosuppression, and immunosuppressive leukemia microenvironment. The 2024 ASH Meeting highlighted several cutting-edge advancements in AML-directed CAR T therapies, including clinical trials targeting CD33, CD123, CLL1, CD19, and IL1RAP, as well as novel engineering strategies such as dual-targeting CARs, inhibitory CAR designs, and genome-editing approaches to enhance safety and efficacy. Here, we summarize key findings from both clinical and preclinical studies, offering insights into the evolving landscape of CAR T-cell therapy for AML.
期刊介绍：
Experimental Hematology & Oncology is an open access journal that encompasses all aspects of hematology and oncology with an emphasis on preclinical, basic, patient-oriented and translational research. The journal acts as an international platform for sharing laboratory findings in these areas and makes a deliberate effort to publish clinical trials with 'negative' results and basic science studies with provocative findings.
Experimental Hematology & Oncology publishes original work, hypothesis, commentaries and timely reviews. With open access and rapid turnaround time from submission to publication, the journal strives to be a hub for disseminating new knowledge and discussing controversial topics for both basic scientists and busy clinicians in the closely related fields of hematology and oncology.
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