嗜酸性肉芽肿性多血管炎合并自身免疫性溶血性贫血1例报告及文献复习。

IF 3 3区 医学 Q2 ALLERGY
Journal of Asthma and Allergy Pub Date : 2025-04-24 eCollection Date: 2025-01-01 DOI:10.2147/JAA.S506965
Mengrong Xie, Ruiqin Ni, Jingying Zhang, Mingmei Zhong, Ping Wang
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引用次数: 0

摘要

EGPA可影响多器官系统,通常以呼吸道症状为首发表现。缺乏特定的诊断性生物标志物使其容易误诊。本文描述了一位40岁的女性患者,她表现为哮喘样症状、神经感觉障碍、贫血、外周血嗜酸性粒细胞增多和肺部受累。诊断为EGPA合并AIHA。单纯糖皮质激素治疗无效后,加入免疫抑制剂环磷酰胺可缓解患者症状。总剂量达到7g后停用环磷酰胺,患者复发。患者的后续治疗包括糖皮质激素和MMF的联合治疗,没有复发的证据。本病例在临床上比较少见,所幸最终治疗效果令人满意。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Eosinophilic Granulomatous Polyangiitis with Autoimmune Hemolytic Anemia: A Case Report and Review of the Literature.

Eosinophilic Granulomatous Polyangiitis with Autoimmune Hemolytic Anemia: A Case Report and Review of the Literature.

EGPA can affect multiple organ systems, typically presenting with respiratory symptoms as the initial manifestation. The absence of specific diagnostic biomarkers makes it prone to misdiagnosis. This article describes a 40-year-old female patient who presented with asthma-like symptoms, neurosensory impairment, anemia, peripheral blood eosinophilia, and pulmonary involvement. The patient was diagnosed with EGPA combined with AIHA. After ineffective treatment with glucocorticoids alone, the patients' symptoms were relieved by the addition of the immunosuppressant cyclophosphamide. Cyclophosphamide was discontinued after the total dose reached 7g and the patient relapsed. Subsequent treatment for the patients involved a combination of glucocorticoids and MMF, with no evidence of recurrence. This case is relatively rare in clinical practice, and fortunately the final treatment effect is satisfactory.

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来源期刊
Journal of Asthma and Allergy
Journal of Asthma and Allergy Medicine-Immunology and Allergy
CiteScore
5.30
自引率
6.20%
发文量
185
审稿时长
16 weeks
期刊介绍: An international, peer-reviewed journal publishing original research, reports, editorials and commentaries on the following topics: Asthma; Pulmonary physiology; Asthma related clinical health; Clinical immunology and the immunological basis of disease; Pharmacological interventions and new therapies. Although the main focus of the journal will be to publish research and clinical results in humans, preclinical, animal and in vitro studies will be published where they shed light on disease processes and potential new therapies.
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