Maja Vuković, Miloš Maksimović, Siniša Ristić, Milan Kulić, Biljana Mijović, Marija Milić, Nenad Lalović, Nikolina Elez-Burnjaković, Danijela Radulović, Dajana Nogo-Živanović, Ljiljana Krsmanović, Nada Avram, Biljana Milinković, Siniša Šolaja, Sandra Matović, Jovan Kulić, Bojan Joksimović
{"title":"波斯尼亚和黑塞哥维那2型糖尿病患者中脂联素和抵抗素基因多态性与营养不良风险的关系","authors":"Maja Vuković, Miloš Maksimović, Siniša Ristić, Milan Kulić, Biljana Mijović, Marija Milić, Nenad Lalović, Nikolina Elez-Burnjaković, Danijela Radulović, Dajana Nogo-Živanović, Ljiljana Krsmanović, Nada Avram, Biljana Milinković, Siniša Šolaja, Sandra Matović, Jovan Kulić, Bojan Joksimović","doi":"10.18502/ijph.v54i4.18420","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Undernutrition disorder is a prevalent comorbidity (up to 25%) in type 2 diabetes (T2D) patients which significantly compromises their health. We aimed to assess the association between single nucleotide polymorphysms (SNPs) adiponectin (<i>ADIPOQ)</i> +276 (G/T) and resistin (<i>RETN)</i> -420 (C/G) with the risk of developing T2D and undernutrition in patients with T2D.</p><p><strong>Methods: </strong>The research was conducted as prospective case-control study among 106 patients with T2D and 106 healthy control individuals in the territory of the Bosnia and Herzegovina from Sep 1st 2022 to May 1st 2023. For assessing the nutritional status, the mini nutritional assessment (MNA) was used. DNA analysis was carried out by restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) method. The data were analyzed using chi-square test, t-test for independent samples and binary multivariate logistic regression.</p><p><strong>Results: </strong>The research included 212 subjects of which 124 (58.5%) were male. The mean age of the subjects was 68.48±4,67 yr. Almost 20% of subjects were undernourished, significantly more T2D patients when compared to controls (33% vs. 6.6%; <i>P</i><0.001). <i>ADIPOQ</i> +276 GT genotype was identified as significant predictor of T2D (OR: 3.454; 95% CI: 1.400-8.521; <i>P</i>=0.007) and undernutrition disorder (OR: 3.453; 95% CI: 1.331-8.961; <i>P</i>=0.011) in T2D population, while the presence of <i>RETN</i> -420 CG genotype had protective effect against occurrence of T2D (OR: 0.353; 95% CI: 0.144-0.867; <i>P</i>=0.023). However, <i>RETN</i> genotypes were not associated with undernutrition disorder.</p><p><strong>Conclusion: </strong><i>ADIPOQ</i> +276 gene polymorphism represent a significant predictor for development of T2D and undernutrition disorder in T2D population, while <i>RETN</i> -420 gene polymorphism was identified as a significant factor associated with a reduced risk for T2D, but was not associated with undernutrition.</p>","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"54 4","pages":"810-819"},"PeriodicalIF":1.4000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045865/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association of Adiponectin and Resistin Gene Polymorphisms with Undernutrition Risk among Type 2 Diabetes Patients in Bosnia and Herzegovina.\",\"authors\":\"Maja Vuković, Miloš Maksimović, Siniša Ristić, Milan Kulić, Biljana Mijović, Marija Milić, Nenad Lalović, Nikolina Elez-Burnjaković, Danijela Radulović, Dajana Nogo-Živanović, Ljiljana Krsmanović, Nada Avram, Biljana Milinković, Siniša Šolaja, Sandra Matović, Jovan Kulić, Bojan Joksimović\",\"doi\":\"10.18502/ijph.v54i4.18420\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Undernutrition disorder is a prevalent comorbidity (up to 25%) in type 2 diabetes (T2D) patients which significantly compromises their health. We aimed to assess the association between single nucleotide polymorphysms (SNPs) adiponectin (<i>ADIPOQ)</i> +276 (G/T) and resistin (<i>RETN)</i> -420 (C/G) with the risk of developing T2D and undernutrition in patients with T2D.</p><p><strong>Methods: </strong>The research was conducted as prospective case-control study among 106 patients with T2D and 106 healthy control individuals in the territory of the Bosnia and Herzegovina from Sep 1st 2022 to May 1st 2023. For assessing the nutritional status, the mini nutritional assessment (MNA) was used. DNA analysis was carried out by restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) method. The data were analyzed using chi-square test, t-test for independent samples and binary multivariate logistic regression.</p><p><strong>Results: </strong>The research included 212 subjects of which 124 (58.5%) were male. The mean age of the subjects was 68.48±4,67 yr. Almost 20% of subjects were undernourished, significantly more T2D patients when compared to controls (33% vs. 6.6%; <i>P</i><0.001). <i>ADIPOQ</i> +276 GT genotype was identified as significant predictor of T2D (OR: 3.454; 95% CI: 1.400-8.521; <i>P</i>=0.007) and undernutrition disorder (OR: 3.453; 95% CI: 1.331-8.961; <i>P</i>=0.011) in T2D population, while the presence of <i>RETN</i> -420 CG genotype had protective effect against occurrence of T2D (OR: 0.353; 95% CI: 0.144-0.867; <i>P</i>=0.023). However, <i>RETN</i> genotypes were not associated with undernutrition disorder.</p><p><strong>Conclusion: </strong><i>ADIPOQ</i> +276 gene polymorphism represent a significant predictor for development of T2D and undernutrition disorder in T2D population, while <i>RETN</i> -420 gene polymorphism was identified as a significant factor associated with a reduced risk for T2D, but was not associated with undernutrition.</p>\",\"PeriodicalId\":14685,\"journal\":{\"name\":\"Iranian Journal of Public Health\",\"volume\":\"54 4\",\"pages\":\"810-819\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045865/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Iranian Journal of Public Health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.18502/ijph.v54i4.18420\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Public Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.18502/ijph.v54i4.18420","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Association of Adiponectin and Resistin Gene Polymorphisms with Undernutrition Risk among Type 2 Diabetes Patients in Bosnia and Herzegovina.
Background: Undernutrition disorder is a prevalent comorbidity (up to 25%) in type 2 diabetes (T2D) patients which significantly compromises their health. We aimed to assess the association between single nucleotide polymorphysms (SNPs) adiponectin (ADIPOQ) +276 (G/T) and resistin (RETN) -420 (C/G) with the risk of developing T2D and undernutrition in patients with T2D.
Methods: The research was conducted as prospective case-control study among 106 patients with T2D and 106 healthy control individuals in the territory of the Bosnia and Herzegovina from Sep 1st 2022 to May 1st 2023. For assessing the nutritional status, the mini nutritional assessment (MNA) was used. DNA analysis was carried out by restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) method. The data were analyzed using chi-square test, t-test for independent samples and binary multivariate logistic regression.
Results: The research included 212 subjects of which 124 (58.5%) were male. The mean age of the subjects was 68.48±4,67 yr. Almost 20% of subjects were undernourished, significantly more T2D patients when compared to controls (33% vs. 6.6%; P<0.001). ADIPOQ +276 GT genotype was identified as significant predictor of T2D (OR: 3.454; 95% CI: 1.400-8.521; P=0.007) and undernutrition disorder (OR: 3.453; 95% CI: 1.331-8.961; P=0.011) in T2D population, while the presence of RETN -420 CG genotype had protective effect against occurrence of T2D (OR: 0.353; 95% CI: 0.144-0.867; P=0.023). However, RETN genotypes were not associated with undernutrition disorder.
Conclusion: ADIPOQ +276 gene polymorphism represent a significant predictor for development of T2D and undernutrition disorder in T2D population, while RETN -420 gene polymorphism was identified as a significant factor associated with a reduced risk for T2D, but was not associated with undernutrition.
期刊介绍：
Iranian Journal of Public Health has been continuously published since 1971, as the only Journal in all health domains, with wide distribution (including WHO in Geneva and Cairo) in two languages (English and Persian). From 2001 issue, the Journal is published only in English language. During the last 41 years more than 2000 scientific research papers, results of health activities, surveys and services, have been published in this Journal. To meet the increasing demand of respected researchers, as of January 2012, the Journal is published monthly. I wish this will assist to promote the level of global knowledge. The main topics that the Journal would welcome are: Bioethics, Disaster and Health, Entomology, Epidemiology, Health and Environment, Health Economics, Health Services, Immunology, Medical Genetics, Mental Health, Microbiology, Nutrition and Food Safety, Occupational Health, Oral Health. We would be very delighted to receive your Original papers, Review Articles, Short communications, Case reports and Scientific Letters to the Editor on the above mentioned research areas.
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