在Reactome中推进病毒生命周期、宿主相互作用和治疗方法的管理。

IF 4 2区医学 Q2 VIROLOGY

Journal of Virology Pub Date : 2025-05-20 Epub Date: 2025-04-23 DOI:10.1128/jvi.02024-24

Lisa Matthews, Justin Cook, Ralf Stephan, Marija Milacic, Karen Rothfels, Veronica Shamovsky, Bijay Jassal, Robin Haw, Cristoffer Sevilla, Chuqiao Gong, Eliot Ragueneau, Bruce May, Adam Wright, Joel Weiser, Deidre Beavers, Krishna Tiwari, Andrea Senff-Ribeiro, Thawfeek Varusai, Henning Hermjakob, Peter D'Eustachio, Guanming Wu, Lincoln Stein, Marc E Gillespie

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引用次数: 0

摘要

Reactome （reactome.org）是一个人工策划的、同行评审的、开源的、开放获取的基本人类细胞功能途径知识库。Reactome包括捕获广泛的病毒诱导的人类病理的病毒生命周期。在这里，我们描述了一个使用协作策展策略、正交推理程序和文献分类的工作流程，以快速创建可靠的突发病毒分子模型。由此产生的途径数据集严格详细病毒感染途径，与正常人类生物过程的相互作用，以及潜在的治疗化合物。

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Advancing curation of viral life cycles, host interactions, and therapeutics in Reactome.

Reactome (reactome.org) is a manually curated, peer-reviewed, open-source, open-access pathway knowledgebase of essential human cellular functions. Reactome includes viral life cycles that capture a broad range of virus-induced human pathology. Here, we describe a workflow using collaborative curation strategies, orthoinference procedures, and literature triage to rapidly create reliable molecular models of emergent viruses. The resulting pathway data set rigorously details viral infection pathways, interactions with normal human biological processes, and potential therapeutic compounds.

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来源期刊

Journal of Virology 医学-病毒学

CiteScore

10.10

自引率

7.40%

发文量

906

审稿时长

1 months

期刊介绍： Journal of Virology (JVI) explores the nature of the viruses of animals, archaea, bacteria, fungi, plants, and protozoa. We welcome papers on virion structure and assembly, viral genome replication and regulation of gene expression, genetic diversity and evolution, virus-cell interactions, cellular responses to infection, transformation and oncogenesis, gene delivery, viral pathogenesis and immunity, and vaccines and antiviral agents.