在雌激素受体阳性her2阴性乳腺癌的辅助和新辅助队列中,MammaPrint与组织病理变量的相关性和Magee方程的比较。

IF 1.3 4区 医学 Q3 ANATOMY & MORPHOLOGY
Mariel Bedell, Tatiana M Villatoro, Stephanie N David, Beth Z Clark, Jeffrey L Fine, Jing Yu, Rohit Bhargava
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引用次数: 0

摘要

MammaPrint (MP)是一种多基因检测方法,用于早期ER+/ her2阴性乳腺癌(BC)的预后和预测。MP与组织病理学变量的相关性数据有限,包括多变量模型Magee方程(MEs)。我们比较了辅助治疗中365例ER+/ her2阴性bc的病理变量和MP。此外,我们分析了26例接受新辅助化疗(NACT)的核心活检证实的ER+/ her2阴性bc的MP和ME结果。通过残余癌症负担(RCB)评分评估nact后的反应。在辅助队列(n=365)中,高危MP与高Nottingham评分、低孕激素受体h评分、导管形态、高Ki-67指数和高ME评分相关。在新辅助治疗组(n=26)中,24例MP- hr, 2例MP低危(MP- lr)。2例MP-LR患者ME平均评分≤25分,RCB评分为2或3分。24例MP-HR中,2例RCB-0或RCB-1。这两例患者的平均ME bbb25和其他7例患者的RCB-0和RCB-1发生率分别为22%(2 / 9)和8%(2 / 24)。26例患者中有17例(65%)的平均ME≤25准确预测了NACT (RCB-2或RCB-3)缺乏显著获益,而26例MP-LR患者中只有2例(8%)。MP与侵袭性组织病理特征相关。虽然MP和ME都确定了具有强大化疗反应的病例,但MP高估了将受益的病例。因此,MEs可以更准确地预测对NACT的反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Correlation of MammaPrint to Histopathologic Variables and Comparison to Magee Equations in Adjuvant and Neoadjuvant Cohorts of Estrogen-Receptor Positive HER2-Negative Breast Carcinoma.

MammaPrint (MP) is a multigene assay utilized for prognostic and predictive use in early stage ER+/HER2-negative breast cancer (BC). There is limited data on MP correlation to histopathologic variables, including multivariable model Magee Equations (MEs). We compared pathologic variables to MP on 365 ER+/HER2-negative BCs in the adjuvant setting. Further, we analyzed MP and ME results in 26 core biopsy-proven ER+/HER2-negative BCs subjected to neoadjuvant chemotherapy (NACT). Post-NACT response was assessed by residual cancer burden (RCB) score. In the adjuvant cohort (n=365), high-risk (HR) MP correlated with high Nottingham score, low progesterone receptor H-score, ductal morphology, high Ki-67 index, and high ME score. In the neoadjuvant cohort (n=26), 24 were MP-HR and 2 were MP low-risk (MP-LR). The 2 MP-LR cases correlated with average ME scores of ≤25 and showed RCB scores of 2 or 3. Of the 24 MP-HR, 2 showed RCB-0 or RCB-1. Average ME>25 was seen in both of these cases and 7 others corresponding to an RCB-0 and RCB-1 rate of 22% (2 of 9) with ME>25 compared with 8% (2 of 24) with MP-HR. Lack of significant benefit from NACT (RCB-2 or RCB-3) was accurately predicted by average ME≤25 in 17 of 26 cases (65%) compared with only 2 of 26 cases (8%) with MP-LR. MP correlates with aggressive histopathologic features. While both MP and ME identified cases with robust chemotherapeutic response, MP overpredicted cases that would benefit. Therefore, MEs may more accurately predict response to NACT.

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来源期刊
Applied Immunohistochemistry & Molecular Morphology
Applied Immunohistochemistry & Molecular Morphology ANATOMY & MORPHOLOGY-MEDICAL LABORATORY TECHNOLOGY
CiteScore
3.20
自引率
0.00%
发文量
153
期刊介绍: ​Applied Immunohistochemistry & Molecular Morphology covers newly developed identification and detection technologies, and their applications in research and diagnosis for the applied immunohistochemist & molecular Morphologist. Official Journal of the International Society for Immunohistochemisty and Molecular Morphology​.
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