{"title":"天冬氨酸转氨酶与血小板比值在预测妊娠肝内胆汁淤积中的作用。","authors":"Nizamettin Bozbay, Şeyma Kılıç, Osman Yıldırım, Aybike Tazegül Pekin, Gökçen Örgül","doi":"10.5114/ceh.2024.145447","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim of the study: </strong>We aimed to compare the first, second and third trimester APRI (aspartate aminotransferase to platelet ratio index) scores in pregnant women with and without intrahepatic cholestasis (ICH).</p><p><strong>Material and methods: </strong>In this study, 54 patients diagnosed with ICH and 59 healthy pregnant women admitted to a tertiary care center between 2018 and 2024 were evaluated. APRI scores were compared between the two groups for three trimesters (first, second, and third trimester). The optimal cut-off values of the APRI score for the prediction of ICH were analyzed.</p><p><strong>Results: </strong>APRI scores were significantly higher in the ICH group in all trimesters (<i>p</i> = 0.028, <i>p</i> < 0.001, <i>p</i> < 0.001, respectively). The optimal cut-off value for APRI score to predict ICH in the first, second, and third trimesters was 0.06 (42.6% sensitivity, 83.1% specificity), 0.1 (57.4% sensitivity, 93.2% specificity) and 13 (77.8% sensitivity, 98.3% specificity), respectively.</p><p><strong>Conclusions: </strong>APRI score was found to be a significant predictor of ICH throughout the entire pregnancy. APRI score seems to be a useful marker in clinical practice to predict ICH.</p>","PeriodicalId":10281,"journal":{"name":"Clinical and Experimental Hepatology","volume":"10 4","pages":"285-290"},"PeriodicalIF":1.7000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022614/pdf/","citationCount":"0","resultStr":"{\"title\":\"Role of aspartate aminotransferase to platelet ratio in prediction of intrahepatic cholestasis of pregnancy.\",\"authors\":\"Nizamettin Bozbay, Şeyma Kılıç, Osman Yıldırım, Aybike Tazegül Pekin, Gökçen Örgül\",\"doi\":\"10.5114/ceh.2024.145447\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim of the study: </strong>We aimed to compare the first, second and third trimester APRI (aspartate aminotransferase to platelet ratio index) scores in pregnant women with and without intrahepatic cholestasis (ICH).</p><p><strong>Material and methods: </strong>In this study, 54 patients diagnosed with ICH and 59 healthy pregnant women admitted to a tertiary care center between 2018 and 2024 were evaluated. APRI scores were compared between the two groups for three trimesters (first, second, and third trimester). The optimal cut-off values of the APRI score for the prediction of ICH were analyzed.</p><p><strong>Results: </strong>APRI scores were significantly higher in the ICH group in all trimesters (<i>p</i> = 0.028, <i>p</i> < 0.001, <i>p</i> < 0.001, respectively). The optimal cut-off value for APRI score to predict ICH in the first, second, and third trimesters was 0.06 (42.6% sensitivity, 83.1% specificity), 0.1 (57.4% sensitivity, 93.2% specificity) and 13 (77.8% sensitivity, 98.3% specificity), respectively.</p><p><strong>Conclusions: </strong>APRI score was found to be a significant predictor of ICH throughout the entire pregnancy. APRI score seems to be a useful marker in clinical practice to predict ICH.</p>\",\"PeriodicalId\":10281,\"journal\":{\"name\":\"Clinical and Experimental Hepatology\",\"volume\":\"10 4\",\"pages\":\"285-290\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022614/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical and Experimental Hepatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5114/ceh.2024.145447\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/12/2 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Experimental Hepatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5114/ceh.2024.145447","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/2 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
研究目的：我们的目的是比较有和没有肝内胆汁淤积（ICH）的孕妇在妊娠早期、中期和晚期的APRI（天冬氨酸转氨酶血小板比率指数）评分。材料与方法：本研究对2018年至2024年间在三级保健中心就诊的54例诊断为ICH的患者和59例健康孕妇进行评估。比较两组妊娠3个月（妊娠1、2、3个月）APRI评分。分析了APRI评分预测脑出血的最佳临界值。结果：ICH组APRI评分在各妊娠期均显著高于对照组（p = 0.028, p < 0.001, p < 0.001）。APRI评分预测妊娠早期、中期和晚期脑出血的最佳临界值分别为0.06（敏感性42.6%，特异性83.1%）、0.1（敏感性57.4%，特异性93.2%）和13（敏感性77.8%，特异性98.3%）。结论：APRI评分是整个妊娠期脑出血的重要预测指标。在临床实践中，APRI评分似乎是预测脑出血的有用指标。
Role of aspartate aminotransferase to platelet ratio in prediction of intrahepatic cholestasis of pregnancy.
Aim of the study: We aimed to compare the first, second and third trimester APRI (aspartate aminotransferase to platelet ratio index) scores in pregnant women with and without intrahepatic cholestasis (ICH).
Material and methods: In this study, 54 patients diagnosed with ICH and 59 healthy pregnant women admitted to a tertiary care center between 2018 and 2024 were evaluated. APRI scores were compared between the two groups for three trimesters (first, second, and third trimester). The optimal cut-off values of the APRI score for the prediction of ICH were analyzed.
Results: APRI scores were significantly higher in the ICH group in all trimesters (p = 0.028, p < 0.001, p < 0.001, respectively). The optimal cut-off value for APRI score to predict ICH in the first, second, and third trimesters was 0.06 (42.6% sensitivity, 83.1% specificity), 0.1 (57.4% sensitivity, 93.2% specificity) and 13 (77.8% sensitivity, 98.3% specificity), respectively.
Conclusions: APRI score was found to be a significant predictor of ICH throughout the entire pregnancy. APRI score seems to be a useful marker in clinical practice to predict ICH.
期刊介绍：
Clinical and Experimental Hepatology – quarterly of the Polish Association for Study of Liver – is a scientific and educational, peer-reviewed journal publishing original and review papers describing clinical and basic investigations in the field of hepatology.
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