衰老和慢性炎症对嗅觉功能障碍的影响综述。

IF 6.2 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cellular and Molecular Life Sciences Pub Date : 2025-05-13 DOI:10.1007/s00018-025-05637-5

Yingqi Xie, Shenglei Wang, Xudong Cha, Fengzhen Li, Zengyi Xu, Jian Wu, Huanhai Liu, Wenwen Ren

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引用次数: 0

摘要

嗅觉功能障碍（Olfactory dysfunction， OD）是一种常见的鼻腔疾病，在老年人中尤为普遍，严重影响患者的生活质量。本文综述了衰老和慢性炎症对嗅觉功能障碍的影响，从外周和中枢嗅觉系统两方面提出了见解。通过探索嗅觉功能障碍发生的分子机制和病理变化与年龄相关疾病和慢性炎症的关系，为进一步研究嗅觉功能障碍提供全面的理论基础，并为更有效地治疗嗅觉功能障碍提供有价值的见解。

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Aging and chronic inflammation: impacts on olfactory dysfunction-a comprehensive review.

Olfactory dysfunction (OD) is a common nasal disease, particularly prevalent among the elderly population, significantly impacting the affected individuals' quality of life. This review focuses on the influence of aging and chronic inflammation on olfactory dysfunction, presenting insights from both the peripheral and central olfactory systems. By exploring the molecular mechanisms and pathological changes underlying the occurrence of olfactory dysfunction in relation to age-related diseases and chronic inflammation conditions, we aim to provide a comprehensive theoretical foundation for further research and offer valuable insights for more effective treatment of olfactory dysfunction.

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来源期刊

Cellular and Molecular Life Sciences 生物-生化与分子生物学

CiteScore

13.20

自引率

1.20%

发文量

546

审稿时长

1.0 months

期刊介绍： Journal Name: Cellular and Molecular Life Sciences (CMLS) Location: Basel, Switzerland Focus: Multidisciplinary journal Publishes research articles, reviews, multi-author reviews, and visions & reflections articles Coverage: Latest aspects of biological and biomedical research Areas include: Biochemistry and molecular biology Cell biology Molecular and cellular aspects of biomedicine Neuroscience Pharmacology Immunology Additional Features: Welcomes comments on any article published in CMLS Accepts suggestions for topics to be covered