{"title":"一种有效、安全的二氧化碳激光治疗中国眼窝周围皱纹的方法：一项随机裂面试验。","authors":"Xianglei Wu, Qingqing Cen, Jian Jin, Wei Gao, Ying Shang, Linting Huang, Xiaoxi Lin","doi":"10.1007/s13555-025-01404-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Ablative carbon dioxide fractional laser (CO<sub>2</sub> AFL) can alleviate static wrinkles; however, its use in East Asian populations can predispose them to postinflammatory hyperpigmentation (PIH). We aimed to explore the optimum energy and coverage parameters of CO<sub>2</sub> AFL for treating static periorbital wrinkles in a Chinese population and to minimize PIH incidence.</p><p><strong>Methods: </strong>In total, 30 patients with static periorbital wrinkles were recruited. The PIH intervention side (1% hydroquinone cream every night on one periorbital area for each patient 1 month before and from the 8th day to 1 month after each treatment) and group (group A: 15‒20 mJ, 5%; group B: 10‒12.5 mJ, 15%; and group C: 12.5‒15 mJ, 10%) were determined randomly. The patients underwent two sessions of CO<sub>2</sub> AFL at 3-month intervals. Follow-ups were conducted until 6 months after the last treatment.</p><p><strong>Results: </strong>Overall, 20 participants (48.1 ± 13.1 years) completed all follow-ups without any serious complications. The application of hydroquinone significantly reduced PIH (p = 0.02). Both the investigators' and patients' visual evaluations demonstrated a consistent efficacy rate of 68.2% without differences between groups. The Fitzpatrick wrinkle score significantly decreased compared with pre-treatment (p < 0.01); however, a significant reduction only in group B at 3 months (p = 0.016) and 6 months (p = 0.001) post-treatment was observed. Groups B and C demonstrated significant reductions in superficial and deep wrinkles and pigmentation (p < 0.01).</p><p><strong>Conclusions: </strong>CO<sub>2</sub> AFL effectively reduced static periorbital wrinkles in the Chinese population. Low energy combined with high-density coverage was the most efficacious. The application of hydroquinone significantly reduced PIH incidence.</p><p><strong>Trial registration: </strong>Chinese Clinical Trial Registration no. ChiCTR2400087320 (date of trial registration: 25 July 2024).</p>","PeriodicalId":11186,"journal":{"name":"Dermatology and Therapy","volume":" ","pages":"1307-1317"},"PeriodicalIF":3.5000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092846/pdf/","citationCount":"0","resultStr":"{\"title\":\"An Effective and Safe Laser Treatment Strategy of Fractional Carbon Dioxide Laser for Chinese Populations with Periorbital Wrinkles: A Randomized Split-Face Trial.\",\"authors\":\"Xianglei Wu, Qingqing Cen, Jian Jin, Wei Gao, Ying Shang, Linting Huang, Xiaoxi Lin\",\"doi\":\"10.1007/s13555-025-01404-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Ablative carbon dioxide fractional laser (CO<sub>2</sub> AFL) can alleviate static wrinkles; however, its use in East Asian populations can predispose them to postinflammatory hyperpigmentation (PIH). We aimed to explore the optimum energy and coverage parameters of CO<sub>2</sub> AFL for treating static periorbital wrinkles in a Chinese population and to minimize PIH incidence.</p><p><strong>Methods: </strong>In total, 30 patients with static periorbital wrinkles were recruited. The PIH intervention side (1% hydroquinone cream every night on one periorbital area for each patient 1 month before and from the 8th day to 1 month after each treatment) and group (group A: 15‒20 mJ, 5%; group B: 10‒12.5 mJ, 15%; and group C: 12.5‒15 mJ, 10%) were determined randomly. The patients underwent two sessions of CO<sub>2</sub> AFL at 3-month intervals. Follow-ups were conducted until 6 months after the last treatment.</p><p><strong>Results: </strong>Overall, 20 participants (48.1 ± 13.1 years) completed all follow-ups without any serious complications. The application of hydroquinone significantly reduced PIH (p = 0.02). Both the investigators' and patients' visual evaluations demonstrated a consistent efficacy rate of 68.2% without differences between groups. The Fitzpatrick wrinkle score significantly decreased compared with pre-treatment (p < 0.01); however, a significant reduction only in group B at 3 months (p = 0.016) and 6 months (p = 0.001) post-treatment was observed. Groups B and C demonstrated significant reductions in superficial and deep wrinkles and pigmentation (p < 0.01).</p><p><strong>Conclusions: </strong>CO<sub>2</sub> AFL effectively reduced static periorbital wrinkles in the Chinese population. Low energy combined with high-density coverage was the most efficacious. The application of hydroquinone significantly reduced PIH incidence.</p><p><strong>Trial registration: </strong>Chinese Clinical Trial Registration no. ChiCTR2400087320 (date of trial registration: 25 July 2024).</p>\",\"PeriodicalId\":11186,\"journal\":{\"name\":\"Dermatology and Therapy\",\"volume\":\" \",\"pages\":\"1307-1317\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092846/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dermatology and Therapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s13555-025-01404-3\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/12 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dermatology and Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s13555-025-01404-3","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/12 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"DERMATOLOGY","Score":null,"Total":0}
An Effective and Safe Laser Treatment Strategy of Fractional Carbon Dioxide Laser for Chinese Populations with Periorbital Wrinkles: A Randomized Split-Face Trial.
Introduction: Ablative carbon dioxide fractional laser (CO2 AFL) can alleviate static wrinkles; however, its use in East Asian populations can predispose them to postinflammatory hyperpigmentation (PIH). We aimed to explore the optimum energy and coverage parameters of CO2 AFL for treating static periorbital wrinkles in a Chinese population and to minimize PIH incidence.
Methods: In total, 30 patients with static periorbital wrinkles were recruited. The PIH intervention side (1% hydroquinone cream every night on one periorbital area for each patient 1 month before and from the 8th day to 1 month after each treatment) and group (group A: 15‒20 mJ, 5%; group B: 10‒12.5 mJ, 15%; and group C: 12.5‒15 mJ, 10%) were determined randomly. The patients underwent two sessions of CO2 AFL at 3-month intervals. Follow-ups were conducted until 6 months after the last treatment.
Results: Overall, 20 participants (48.1 ± 13.1 years) completed all follow-ups without any serious complications. The application of hydroquinone significantly reduced PIH (p = 0.02). Both the investigators' and patients' visual evaluations demonstrated a consistent efficacy rate of 68.2% without differences between groups. The Fitzpatrick wrinkle score significantly decreased compared with pre-treatment (p < 0.01); however, a significant reduction only in group B at 3 months (p = 0.016) and 6 months (p = 0.001) post-treatment was observed. Groups B and C demonstrated significant reductions in superficial and deep wrinkles and pigmentation (p < 0.01).
Conclusions: CO2 AFL effectively reduced static periorbital wrinkles in the Chinese population. Low energy combined with high-density coverage was the most efficacious. The application of hydroquinone significantly reduced PIH incidence.
Trial registration: Chinese Clinical Trial Registration no. ChiCTR2400087320 (date of trial registration: 25 July 2024).
期刊介绍：
Dermatology and Therapy is an international, open access, peer-reviewed, rapid publication journal (peer review in 2 weeks, published 3–4 weeks from acceptance). The journal is dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of dermatological therapies. Studies relating to diagnosis, pharmacoeconomics, public health and epidemiology, quality of life, and patient care, management, and education are also encouraged.
Areas of focus include, but are not limited to all clinical aspects of dermatology, such as skin pharmacology; skin development and aging; prevention, diagnosis, and management of skin disorders and melanomas; research into dermal structures and pathology; and all areas of aesthetic dermatology, including skin maintenance, dermatological surgery, and lasers.
The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/case series, trial protocols, and short communications. Dermatology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an International and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. The journal appeals to a global audience and receives submissions from all over the world.
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