Ahmad Faried, Yeremia Tatang, Gibran A Wibawa, Wahyu Widowati, Anindita P Distya
{"title":"分泌组联合间充质干细胞成功治疗创伤性轴索损伤。","authors":"Ahmad Faried, Yeremia Tatang, Gibran A Wibawa, Wahyu Widowati, Anindita P Distya","doi":"10.12890/2025_005111","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Traumatic axonal injury (TAI), a head injury condition formerly known as diffuse axonal injury, results from direct mechanical forces causing multiple scattered lesions, either haemorrhagic or non-haemorrhagic, within brain tissue. Despite its clinical significance, no prior research has explored the use of stem cells in a TAI inpatient setting. This case presents the efficacy of stem cell therapy for TAI.</p><p><strong>Case description: </strong>A 17-year-old boy sustained severe head injuries from repeated blows, resulting in a coma. Initial CT and MRI scans showed cerebral oedema without haemorrhagic lesions. T2-weighted axial FLAIR imaging showed two hyperintensity lesions in the corpus callosum, consistent with diffuse axonal injury grade II. Secretome and umbilical cord mesenchymal stem cell (UCMSC) therapy were administered. The patient showed improvement in motor function and speaking and was discharged without neurological deficits.</p><p><strong>Discussion: </strong>The pathophysiology of TAI remains unclear because of a lack of unifying theory. It is theorised that not only is direct mechanical injury the cause of primary damage but biochemical changes in neuronal metabolism also play a role as secondary damage. Two main therapeutic options can be recognised. Treatment approaches fall into two categories: secondary axotomy-targeted therapy and promotion of neural regeneration. Multiple treatment options promote both microenvironment correction and neuronal regeneration, including cell and stem cell therapy along with its metabolite.</p><p><strong>Conclusion: </strong>Stem cell therapy is promising as an alternative treatment modality in a case where there was no other optional therapy for TAI.</p><p><strong>Learning points: </strong>A traumatic axonal head injury (TAI) patient in a coma for one month responded within four days of secretome therapy and further improved and became fully alert four days after mesenchymal stem cell treatment.</p>","PeriodicalId":11908,"journal":{"name":"European journal of case reports in internal medicine","volume":"12 4","pages":"005111"},"PeriodicalIF":0.0000,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013209/pdf/","citationCount":"0","resultStr":"{\"title\":\"Traumatic Axonal Injury Successfully Treated with Secretome Followed by Mesenchymal Stem Cells Therapy.\",\"authors\":\"Ahmad Faried, Yeremia Tatang, Gibran A Wibawa, Wahyu Widowati, Anindita P Distya\",\"doi\":\"10.12890/2025_005111\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Traumatic axonal injury (TAI), a head injury condition formerly known as diffuse axonal injury, results from direct mechanical forces causing multiple scattered lesions, either haemorrhagic or non-haemorrhagic, within brain tissue. Despite its clinical significance, no prior research has explored the use of stem cells in a TAI inpatient setting. This case presents the efficacy of stem cell therapy for TAI.</p><p><strong>Case description: </strong>A 17-year-old boy sustained severe head injuries from repeated blows, resulting in a coma. Initial CT and MRI scans showed cerebral oedema without haemorrhagic lesions. T2-weighted axial FLAIR imaging showed two hyperintensity lesions in the corpus callosum, consistent with diffuse axonal injury grade II. Secretome and umbilical cord mesenchymal stem cell (UCMSC) therapy were administered. The patient showed improvement in motor function and speaking and was discharged without neurological deficits.</p><p><strong>Discussion: </strong>The pathophysiology of TAI remains unclear because of a lack of unifying theory. It is theorised that not only is direct mechanical injury the cause of primary damage but biochemical changes in neuronal metabolism also play a role as secondary damage. Two main therapeutic options can be recognised. Treatment approaches fall into two categories: secondary axotomy-targeted therapy and promotion of neural regeneration. Multiple treatment options promote both microenvironment correction and neuronal regeneration, including cell and stem cell therapy along with its metabolite.</p><p><strong>Conclusion: </strong>Stem cell therapy is promising as an alternative treatment modality in a case where there was no other optional therapy for TAI.</p><p><strong>Learning points: </strong>A traumatic axonal head injury (TAI) patient in a coma for one month responded within four days of secretome therapy and further improved and became fully alert four days after mesenchymal stem cell treatment.</p>\",\"PeriodicalId\":11908,\"journal\":{\"name\":\"European journal of case reports in internal medicine\",\"volume\":\"12 4\",\"pages\":\"005111\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-03-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013209/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European journal of case reports in internal medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.12890/2025_005111\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European journal of case reports in internal medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12890/2025_005111","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Traumatic Axonal Injury Successfully Treated with Secretome Followed by Mesenchymal Stem Cells Therapy.
Introduction: Traumatic axonal injury (TAI), a head injury condition formerly known as diffuse axonal injury, results from direct mechanical forces causing multiple scattered lesions, either haemorrhagic or non-haemorrhagic, within brain tissue. Despite its clinical significance, no prior research has explored the use of stem cells in a TAI inpatient setting. This case presents the efficacy of stem cell therapy for TAI.
Case description: A 17-year-old boy sustained severe head injuries from repeated blows, resulting in a coma. Initial CT and MRI scans showed cerebral oedema without haemorrhagic lesions. T2-weighted axial FLAIR imaging showed two hyperintensity lesions in the corpus callosum, consistent with diffuse axonal injury grade II. Secretome and umbilical cord mesenchymal stem cell (UCMSC) therapy were administered. The patient showed improvement in motor function and speaking and was discharged without neurological deficits.
Discussion: The pathophysiology of TAI remains unclear because of a lack of unifying theory. It is theorised that not only is direct mechanical injury the cause of primary damage but biochemical changes in neuronal metabolism also play a role as secondary damage. Two main therapeutic options can be recognised. Treatment approaches fall into two categories: secondary axotomy-targeted therapy and promotion of neural regeneration. Multiple treatment options promote both microenvironment correction and neuronal regeneration, including cell and stem cell therapy along with its metabolite.
Conclusion: Stem cell therapy is promising as an alternative treatment modality in a case where there was no other optional therapy for TAI.
Learning points: A traumatic axonal head injury (TAI) patient in a coma for one month responded within four days of secretome therapy and further improved and became fully alert four days after mesenchymal stem cell treatment.
期刊介绍:
The European Journal of Case Reports in Internal Medicine is an official journal of the European Federation of Internal Medicine (EFIM), representing 35 national societies from 33 European countries. The Journal''s mission is to promote the best medical practice and innovation in the field of acute and general medicine. It also provides a forum for internal medicine doctors where they can share new approaches with the aim of improving diagnostic and clinical skills in this field. EJCRIM welcomes high-quality case reports describing unusual or complex cases that an internist may encounter in everyday practice. The cases should either demonstrate the appropriateness of a diagnostic/therapeutic approach, describe a new procedure or maneuver, or show unusual manifestations of a disease or unexpected reactions. The Journal only accepts and publishes those case reports whose learning points provide new insight and/or contribute to advancing medical knowledge both in terms of diagnostics and therapeutic approaches. Case reports of medical errors, therefore, are also welcome as long as they provide innovative measures on how to prevent them in the current practice (Instructive Errors). The Journal may also consider brief and reasoned reports on issues relevant to the practice of Internal Medicine, as well as Abstracts submitted to the scientific meetings of acknowledged medical societies.