Mapping, Modeling, and Reprogramming Cell-Fate Decision-Making Systems.

Many cellular processes involve information processing and decision-making. We can probe these processes at increasing molecular detail. The analysis of heterogeneous data remains a challenge that requires new ways of thinking about cells in quantitative, predictive, and mechanistic ways. We discuss the role of mathematical models in the context of cell-fate decision-making systems across the tree of life. Complex multicellular organisms have been a particular focus, but single-celled organisms also have to sense and respond to their environment. We center our discussion around the idea of design principles that we can learn from observations and modeling and exploit in order to (re)-design or guide cellular behavior.