慢性自发性荨麻疹严重程度与血清tnf - α浓度相关。

IF 1.5 Q3 DERMATOLOGY
Dermatology Research and Practice Pub Date : 2025-04-19 eCollection Date: 2025-01-01 DOI:10.1155/drp/8853778
Thai Van Thanh Le, Khanh Huy Mach, The Bich Thanh Vuong, Thien Tai Tran
{"title":"慢性自发性荨麻疹严重程度与血清tnf - α浓度相关。","authors":"Thai Van Thanh Le, Khanh Huy Mach, The Bich Thanh Vuong, Thien Tai Tran","doi":"10.1155/drp/8853778","DOIUrl":null,"url":null,"abstract":"<p><p><b>Background:</b> Chronic spontaneous urticaria (CSU) is a prevalent skin disorder characterized by frequent recurrences. While its pathogenesis is closely associated with histamine and vascular activating mediators released by mast cells, some research suggests cytokines, notably tumor necrosis factor-alpha (TNF-alpha), could play a pivotal role in its pathology and symptom presentation. <b>Objective:</b> This study evaluated serum levels of TNF-alpha in CSU patients and explored its correlation with clinical symptoms and severity at the University Medical Center at Ho Chi Minh City. <b>Methods:</b> We enrolled 60 adult patients (age ≥ 18) with CSU, assessing their clinical symptoms using the UAS7 scoring system. TNF-alpha levels were determined utilizing the Avi Bion Human TNF-alpha kit. For comparative purposes, we also studied TNF-alpha levels in 30 healthy adult participants as a control group. <b>Results:</b> The male-to-female ratio stood at roughly 1:2.3, and the median age was 36 (28-42). Notably, the mean serum concentrations of TNF-alpha in the patient group were considerably elevated compared to the control group (<i>p</i> < 0.001). A significant positive moderate correlation was found between serum concentrations of TNF-alpha and UAS7 score (<i>r</i> = 0.57; <i>p</i> < 0.001). Similarly, a notable positive moderate correlation between serum levels of TNF-alpha and pruritus scores was observed (<i>r</i> = 0.45; <i>p</i> < 0.001). <b>Conclusion:</b> Serum levels of TNF-alpha are markedly increased in patients with CSU and show a moderate correlation with both UAS7 and pruritus scores. These findings suggest that TNF-alpha might play a potential role in the pathogenesis of CSU. However, further research involving a more extensive sample size is essential to draw definitive conclusions.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2025 ","pages":"8853778"},"PeriodicalIF":1.5000,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033058/pdf/","citationCount":"0","resultStr":"{\"title\":\"Chronic Spontaneous Urticaria Severity Relating to TNF-Alpha Serum Concentration.\",\"authors\":\"Thai Van Thanh Le, Khanh Huy Mach, The Bich Thanh Vuong, Thien Tai Tran\",\"doi\":\"10.1155/drp/8853778\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Background:</b> Chronic spontaneous urticaria (CSU) is a prevalent skin disorder characterized by frequent recurrences. While its pathogenesis is closely associated with histamine and vascular activating mediators released by mast cells, some research suggests cytokines, notably tumor necrosis factor-alpha (TNF-alpha), could play a pivotal role in its pathology and symptom presentation. <b>Objective:</b> This study evaluated serum levels of TNF-alpha in CSU patients and explored its correlation with clinical symptoms and severity at the University Medical Center at Ho Chi Minh City. <b>Methods:</b> We enrolled 60 adult patients (age ≥ 18) with CSU, assessing their clinical symptoms using the UAS7 scoring system. TNF-alpha levels were determined utilizing the Avi Bion Human TNF-alpha kit. For comparative purposes, we also studied TNF-alpha levels in 30 healthy adult participants as a control group. <b>Results:</b> The male-to-female ratio stood at roughly 1:2.3, and the median age was 36 (28-42). Notably, the mean serum concentrations of TNF-alpha in the patient group were considerably elevated compared to the control group (<i>p</i> < 0.001). A significant positive moderate correlation was found between serum concentrations of TNF-alpha and UAS7 score (<i>r</i> = 0.57; <i>p</i> < 0.001). Similarly, a notable positive moderate correlation between serum levels of TNF-alpha and pruritus scores was observed (<i>r</i> = 0.45; <i>p</i> < 0.001). <b>Conclusion:</b> Serum levels of TNF-alpha are markedly increased in patients with CSU and show a moderate correlation with both UAS7 and pruritus scores. These findings suggest that TNF-alpha might play a potential role in the pathogenesis of CSU. However, further research involving a more extensive sample size is essential to draw definitive conclusions.</p>\",\"PeriodicalId\":11338,\"journal\":{\"name\":\"Dermatology Research and Practice\",\"volume\":\"2025 \",\"pages\":\"8853778\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2025-04-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033058/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dermatology Research and Practice\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/drp/8853778\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dermatology Research and Practice","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/drp/8853778","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

背景:慢性自发性荨麻疹(CSU)是一种常见的皮肤疾病,其特点是经常复发。虽然其发病机制与肥大细胞释放的组胺和血管激活介质密切相关,但一些研究表明,细胞因子,特别是肿瘤坏死因子- α (tnf - α)可能在其病理和症状表现中起关键作用。目的:本研究在胡志明市大学医学中心评估CSU患者血清tnf - α水平,并探讨其与临床症状和严重程度的相关性。方法:我们招募了60例成年CSU患者(年龄≥18岁),使用UAS7评分系统评估他们的临床症状。使用Avi Bion Human TNF-alpha试剂盒测定tnf - α水平。为了进行比较,我们还研究了30名健康成人参与者作为对照组的tnf - α水平。结果:男女比例约为1:3 .3,年龄中位数为36岁(28 ~ 42岁)。值得注意的是,与对照组相比,患者组的平均血清tnf - α浓度显著升高(p < 0.001)。血清tnf - α浓度与UAS7评分呈正相关(r = 0.57;P < 0.001)。同样,血清tnf - α水平与瘙痒评分之间存在显著的正相关(r = 0.45;P < 0.001)。结论:CSU患者血清tnf - α水平明显升高,且与UAS7和瘙痒评分均呈中等相关性。这些发现提示tnf - α可能在CSU的发病机制中发挥潜在作用。然而,要得出明确的结论,必须进行涉及更广泛样本量的进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chronic Spontaneous Urticaria Severity Relating to TNF-Alpha Serum Concentration.

Background: Chronic spontaneous urticaria (CSU) is a prevalent skin disorder characterized by frequent recurrences. While its pathogenesis is closely associated with histamine and vascular activating mediators released by mast cells, some research suggests cytokines, notably tumor necrosis factor-alpha (TNF-alpha), could play a pivotal role in its pathology and symptom presentation. Objective: This study evaluated serum levels of TNF-alpha in CSU patients and explored its correlation with clinical symptoms and severity at the University Medical Center at Ho Chi Minh City. Methods: We enrolled 60 adult patients (age ≥ 18) with CSU, assessing their clinical symptoms using the UAS7 scoring system. TNF-alpha levels were determined utilizing the Avi Bion Human TNF-alpha kit. For comparative purposes, we also studied TNF-alpha levels in 30 healthy adult participants as a control group. Results: The male-to-female ratio stood at roughly 1:2.3, and the median age was 36 (28-42). Notably, the mean serum concentrations of TNF-alpha in the patient group were considerably elevated compared to the control group (p < 0.001). A significant positive moderate correlation was found between serum concentrations of TNF-alpha and UAS7 score (r = 0.57; p < 0.001). Similarly, a notable positive moderate correlation between serum levels of TNF-alpha and pruritus scores was observed (r = 0.45; p < 0.001). Conclusion: Serum levels of TNF-alpha are markedly increased in patients with CSU and show a moderate correlation with both UAS7 and pruritus scores. These findings suggest that TNF-alpha might play a potential role in the pathogenesis of CSU. However, further research involving a more extensive sample size is essential to draw definitive conclusions.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
3.80
自引率
0.00%
发文量
16
审稿时长
11 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信