受影响关节的数量仍然是区分青少年特发性关节炎患者的一个标准。

IF 2.4 4区 医学 Q2 RHEUMATOLOGY
Sümeyra Özdemir Çiçek, Nihal Şahin, Ayşenur Paç Kısaarslan, Muammer Hakan Poyrazoğlu
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引用次数: 0

摘要

目的:青少年特发性关节炎是一种异质性的儿童慢性关节炎。我们计划根据国际风湿病协会联盟的标准将低关节、类风湿因子(RF)阴性的多关节和未分化组患者分类,其中大多数患者根据新提出的PRINTO(儿科风湿病国际试验组织)标准属于其他或未分化组,根据其临床和实验室结果分为更均匀的组。方法:对2300例少关节、rf阴性多关节、未分化幼年特发性关节炎患者进行研究。采用两步聚类分析对16个临床和实验室变量进行评估。然后相互比较所产生的群集的临床和实验室特征。结果:聚类分析得到两个聚类。第1组138例(68%),第2组65例(32%)。区分两组患者的主要指标是腕、肘受累程度和受累关节数。聚类1和聚类2受影响关节数分别为2(1 ~ 8)和6(1 ~ 26)个(p < 0.001)。腕部和肩部受累仅见于第2组(p < 0.001)。在第2组中,踝关节、肘关节、小关节和颞下颌关节受累较高。糖皮质激素、改善疾病的抗风湿药物和生物制剂的使用率较高,第2类患者在第12个月和最后一次就诊时的缓解率较低。结论:我们的研究结果将少关节关节炎、rf阴性多关节关节炎和未分化关节炎患者分为两类。腕部和肘部受累情况和受累关节炎的数量是区分两组患者的最重要因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Number of Affected Joints Is Still a Distinguishing Criterion for Classifying Patients With Juvenile Idiopathic Arthritis.

Objective: Juvenile idiopathic arthritis is a heterogeneous group of chronic childhood arthritis. We planned to classify patients with oligoarticular, rheumatoid factor (RF)-negative polyarticular and undifferentiated groups according to the International League of Associations for Rheumatology criteria, most of them in other or undifferentiated groups according to the new proposed PRINTO (Pediatric Rheumatology International Trials Organization) criteria, into more homogeneous groups according to their clinical and laboratory findings.

Methods: Two hundred three patients with oligoarticular, RF-negative polyarticular and undifferentiated juvenile idiopathic arthritis were included in the study. Sixteen clinical and laboratory variables were evaluated using TwoStep Cluster analysis. Clinical and laboratory characteristics of the resulting clusters were then compared with each other.

Results: Two clusters were generated as the result of cluster analysis. Cluster 1 had 138 (68%) and cluster 2 had 65 (32%) patients. The main indicators differentiating 2 clusters were wrist and elbow involvement and the number of affected joints. The number of affected joints was 2 (1-8) and 6 (1-26) in cluster 1 and cluster 2 (p < 0.001). Wrist and shoulder involvements were seen only in cluster 2 (p < 0.001). Ankle, elbow, small joint, and temporomandibular joint involvements were higher in cluster 2. Corticosteroids, disease-modifying antirheumatic drugs, and biologics were used at higher rates, and remissions at the 12th month and last visit were lower in cluster 2.

Conclusions: Our results classified patients with oligoarticular, RF-negative polyarticular, and undifferentiated arthritis into 2 clusters. Wrist and elbow involvements and the number of involved arthritis were the most important factors in differentiating the 2 groups.

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来源期刊
CiteScore
3.50
自引率
2.90%
发文量
228
审稿时长
4-8 weeks
期刊介绍: JCR: Journal of Clinical Rheumatology the peer-reviewed, bimonthly journal that rheumatologists asked for. Each issue contains practical information on patient care in a clinically oriented, easy-to-read format. Our commitment is to timely, relevant coverage of the topics and issues shaping current practice. We pack each issue with original articles, case reports, reviews, brief reports, expert commentary, letters to the editor, and more. This is where you''ll find the answers to tough patient management issues as well as the latest information about technological advances affecting your practice.
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