Shu-Yu Chang, Wen-Shin Chang, Chia-Wen Tsai, Yun-Chi Wang, Hou-Yu Shih, Chen-Hsien Su, DA-Tian Bau
{"title":"基质金属蛋白酶-2启动子基因型与平滑肌瘤风险的关系","authors":"Shu-Yu Chang, Wen-Shin Chang, Chia-Wen Tsai, Yun-Chi Wang, Hou-Yu Shih, Chen-Hsien Su, DA-Tian Bau","doi":"10.21873/cgp.20511","DOIUrl":null,"url":null,"abstract":"<p><strong>Background/aim: </strong>The role of matrix metalloproteinase-2 (MMP-2) in leiomyoma pathogenesis has been suggested, but the association between <i>MMP-2</i> genotypes and leiomyoma risk remains unexplored. This study investigated the impact of two <i>MMP-2</i> polymorphisms, promoter -1306 (rs243865) and promoter -735 (rs2285053), on leiomyoma susceptibility.</p><p><strong>Materials and methods: </strong><i>MMP-2</i> genotypes were analyzed in a cohort of 216 leiomyoma females and 648 non-leiomyoma controls using PCR-based RFLP.</p><p><strong>Results: </strong>Genotypic distributions of <i>MMP-2</i> rs243865 and rs2285053 in controls adhered to Hardy-Weinberg equilibrium (<i>p</i>=0.6161 and 0.3286, respectively). The heterozygous and homozygous variant genotypes of rs243865 were significantly associated with elevated leiomyoma risk (OR=1.63 and 4.33, 95%CI=1.13-2.35 and 1.67-11.16, <i>p</i>=0.0120 and 0.0027, respectively). The dominant model further revealed increased risk for CT and TT genotypes (OR=1.80, 95%CI=1.27-2.56, <i>p</i>=0.0013). The T allele at rs243865 was also significantly linked to higher risk (OR=1.84, 95%CI=1.35-2.50, <i>p</i>=0.0001). No significant association was found for rs2285053. Stratified analysis showed a significant interaction between rs243865 genotypes and age, with elevated risk in older females (<i>p</i> for trend=0.0003) and a notable association with larger tumors (<i>p</i> for trend=0.0029).</p><p><strong>Conclusion: </strong><i>MMP-2</i> rs243865 CT and TT genotypes significantly contribute to leiomyoma risk, particularly in older women and those with larger tumors.</p>","PeriodicalId":9516,"journal":{"name":"Cancer Genomics & Proteomics","volume":"22 3","pages":"434-443"},"PeriodicalIF":2.6000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041871/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association of Matrix Metalloproteinase-2 Promoter Genotypes With Leiomyoma Risk.\",\"authors\":\"Shu-Yu Chang, Wen-Shin Chang, Chia-Wen Tsai, Yun-Chi Wang, Hou-Yu Shih, Chen-Hsien Su, DA-Tian Bau\",\"doi\":\"10.21873/cgp.20511\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background/aim: </strong>The role of matrix metalloproteinase-2 (MMP-2) in leiomyoma pathogenesis has been suggested, but the association between <i>MMP-2</i> genotypes and leiomyoma risk remains unexplored. This study investigated the impact of two <i>MMP-2</i> polymorphisms, promoter -1306 (rs243865) and promoter -735 (rs2285053), on leiomyoma susceptibility.</p><p><strong>Materials and methods: </strong><i>MMP-2</i> genotypes were analyzed in a cohort of 216 leiomyoma females and 648 non-leiomyoma controls using PCR-based RFLP.</p><p><strong>Results: </strong>Genotypic distributions of <i>MMP-2</i> rs243865 and rs2285053 in controls adhered to Hardy-Weinberg equilibrium (<i>p</i>=0.6161 and 0.3286, respectively). The heterozygous and homozygous variant genotypes of rs243865 were significantly associated with elevated leiomyoma risk (OR=1.63 and 4.33, 95%CI=1.13-2.35 and 1.67-11.16, <i>p</i>=0.0120 and 0.0027, respectively). The dominant model further revealed increased risk for CT and TT genotypes (OR=1.80, 95%CI=1.27-2.56, <i>p</i>=0.0013). The T allele at rs243865 was also significantly linked to higher risk (OR=1.84, 95%CI=1.35-2.50, <i>p</i>=0.0001). No significant association was found for rs2285053. Stratified analysis showed a significant interaction between rs243865 genotypes and age, with elevated risk in older females (<i>p</i> for trend=0.0003) and a notable association with larger tumors (<i>p</i> for trend=0.0029).</p><p><strong>Conclusion: </strong><i>MMP-2</i> rs243865 CT and TT genotypes significantly contribute to leiomyoma risk, particularly in older women and those with larger tumors.</p>\",\"PeriodicalId\":9516,\"journal\":{\"name\":\"Cancer Genomics & Proteomics\",\"volume\":\"22 3\",\"pages\":\"434-443\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041871/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cancer Genomics & Proteomics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.21873/cgp.20511\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"GENETICS & HEREDITY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Genomics & Proteomics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.21873/cgp.20511","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
Association of Matrix Metalloproteinase-2 Promoter Genotypes With Leiomyoma Risk.
Background/aim: The role of matrix metalloproteinase-2 (MMP-2) in leiomyoma pathogenesis has been suggested, but the association between MMP-2 genotypes and leiomyoma risk remains unexplored. This study investigated the impact of two MMP-2 polymorphisms, promoter -1306 (rs243865) and promoter -735 (rs2285053), on leiomyoma susceptibility.
Materials and methods: MMP-2 genotypes were analyzed in a cohort of 216 leiomyoma females and 648 non-leiomyoma controls using PCR-based RFLP.
Results: Genotypic distributions of MMP-2 rs243865 and rs2285053 in controls adhered to Hardy-Weinberg equilibrium (p=0.6161 and 0.3286, respectively). The heterozygous and homozygous variant genotypes of rs243865 were significantly associated with elevated leiomyoma risk (OR=1.63 and 4.33, 95%CI=1.13-2.35 and 1.67-11.16, p=0.0120 and 0.0027, respectively). The dominant model further revealed increased risk for CT and TT genotypes (OR=1.80, 95%CI=1.27-2.56, p=0.0013). The T allele at rs243865 was also significantly linked to higher risk (OR=1.84, 95%CI=1.35-2.50, p=0.0001). No significant association was found for rs2285053. Stratified analysis showed a significant interaction between rs243865 genotypes and age, with elevated risk in older females (p for trend=0.0003) and a notable association with larger tumors (p for trend=0.0029).
Conclusion: MMP-2 rs243865 CT and TT genotypes significantly contribute to leiomyoma risk, particularly in older women and those with larger tumors.
期刊介绍：
Cancer Genomics & Proteomics (CGP) is an international peer-reviewed journal designed to publish rapidly high quality articles and reviews on the application of genomic and proteomic technology to basic, experimental and clinical cancer research. In this site you may find information concerning the editorial board, editorial policy, issue contents, subscriptions, submission of manuscripts and advertising. The first issue of CGP circulated in January 2004.
Cancer Genomics & Proteomics is a journal of the International Institute of Anticancer Research. From January 2013 CGP is converted to an online-only open access journal.
Cancer Genomics & Proteomics supports (a) the aims and the research projects of the INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH and (b) the organization of the INTERNATIONAL CONFERENCES OF ANTICANCER RESEARCH.
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