[慢性阻塞性肺疾病患者t2 -气道炎症标志物]。

IF 0.3 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL
G R Sergeeva, A V Emelyanov, E V Leshenkova, A A Znakhurenko
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引用次数: 0

摘要

目的:评估慢性阻塞性肺疾病(COPD)患者的t2炎症生物标志物。材料和方法:我们检查了173例慢性阻塞性肺病成年门诊患者(80%为男性,年龄40-89岁)。肺功能测试使用Spirograph 2120 (Vitalograph, UK)进行评估。采用全自动血液分析仪测定血嗜酸性粒细胞(Eos)。采用血清特异性免疫球蛋白E对常见吸入性过敏原测定特应性状态。呼气一氧化氮分数(FeNO)由化学发光分析仪(LR4100, Logan Research, Rochester, UK)测定。采用俄文版圣乔治呼吸问卷(SGRQ)和慢阻肺评估测试对症状和生活质量进行评估。采用Statistica ver进行统计分析。10.0 (StatSoft公司,美国)。结果:以血Eos≥150细胞/μl(36%)为主,FeNO≥20 ppb较少见,过敏少见(5%),屋尘螨是常见的过敏原。t2dm相关疾病(变应性鼻炎、鼻息肉病、特应性皮炎)占7%。结论:在真实的临床实践中,40%未合并哮喘的COPD患者存在t2 -气道炎症标志物。最常见的指标为血Eos≥150 cell/μl,与COPD加重率相关。伴有t2疾病(变应性鼻炎、鼻息肉、特应性皮炎)的发生率较低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Markers of T2-airway inflammation in patients with chronic obstructive pulmonary disease].

Aim: To assess biomarkers of T2-inflammation in patients with chronic obstructive pulmonary disease (COPD).

Materials and methods: We examined 173 adult outpatients (80% male, age 40-89 yrs) with COPD. Lung function tests were assessed by using the Spirograph 2120 (Vitalograph, UK). Blood eosinophils (Eos) were measured by automatic haemoanalyser. Atopic status was determined by serum specific immunoglobulin E to common inhalant allergens. Fractional exhaled nitric oxide (FeNO) was measured by a chemiluminescence analyzer (LR4100, Logan Research, Rochester, UK). Symptoms and quality of life were assessed by using Russian versions of St. George's Respiratory Questionnaire (SGRQ) and COPD Assessment Test. Statistical analyses were performed with Statistica ver. 10.0 (StatSoft, Inc., USA).

Results: The most frequent marker was blood Eos ≥150 cell/μl (36%), less often was elevated level FeNO≥20 ppb, allergy was rare (5%) and house dust mites were the common allergen. T2-associated diseases (allergic rhinitis, nasal polyposis, atopic dermatitis) were diagnosed in 7% patients.

Conclusion: Forty percent of patients with COPD without concomitant asthma have markers of T2-airway inflammation in a real clinical practice. The most frequent marker was blood Eos≥150 cell/μl that was associated with rate of COPD exacerbation. Frequency of concomitant T2-diseases (allergic rhinitis, nasal polyps, atopic dermatitis) was low.

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来源期刊
Terapevticheskii Arkhiv
Terapevticheskii Arkhiv 医学-医学:内科
CiteScore
1.40
自引率
33.30%
发文量
171
审稿时长
3-8 weeks
期刊介绍: Терапевтический архив The journal was founded by the prominent Russian therapists M.P. Konchalovsky and G.F. Lang in 1923. Then its editors-in-chief were Professors V.N. Vinogradov and A.G. Gukasyan. Since 1972, E.I. Chazov, Academician of the Russian Academy of Sciences, has been heading the editorial board of the journal. Over 90 years, there have been more than 1000 issues where the authors and editorial staff have done their best for readers to keep abreast of current advances in medical science and practice and for physicians to master the advanced principles of recognition and treatment of a wide spectrum of visceral diseases. The papers published in the journal (editorials, original articles, lectures, reviews, etc.) cover both current scientific achievements and practical experience in diagnosing, treating, and preventing visceral diseases. The authors of publications are not only Russian, but also foreign scientists and physicians. All papers are peer-reviewed by highly qualified Russian specialists. The journal is published monthly. Traditionally, each issue has predominantly certain thematic areas covering individual therapy specializations. Every year, one of the issues is devoted to related problems in practical medicine (allergology and immunology, neurology and psychiatry, obstetrics, oncology, etc.). This all draws the attention of the reading public to the journal. The journal is indexed in RSCI (Russian Science Citation Index), PubMed/Medline, Index Medicus, Scopus/EMBASE, Web of Science Core Collection (Science Citation Index Expanded), Web of Science (Russian Science Citation Index - RSCI, Current Contents Connect, BIOSIS Previews), Google Scholar, Ulrich''s Periodicals Directory. The journal is included in the list of periodicals recommended by the Higher Attestation Committee for publishing the papers containing the basic materials of doctoral and candidate dissertations. By the decision of the Presidium of the Russian Academy of Medical Sciences, the “Therapevticheskiy Arkhiv” was awarded the Botkin medal. It was admitted to the European Association of Sciences Editors (EASE). The journal was honored with the Golden Press Fund decoration at the 13th International Press Professional Exhibition.
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