急性早幼粒细胞白血病合并线粒体疾病1例。

IF 1.8 4区医学 Q3 HEMATOLOGY

International Journal of Hematology Pub Date : 2025-08-01 Epub Date: 2025-05-01 DOI:10.1007/s12185-025-03992-4

Yukari Sakurai, Masakatsu Yanagimachi, Mieko Ito, Ayana Hirose, Naoyuki Miyagawa, Dai Keino, Tomoko Yokosuka, Fuminori Iwasaki, Satoshi Hamanoue, Masae Shiomi, Shoko Goto, Tomohide Goto, Hiroaki Goto

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引用次数: 0

摘要

一名患有先天性线粒体疾病的15岁男孩被诊断为急性早幼粒细胞白血病。他接受了全反式维甲酸治疗，并根据他的潜在情况减少了蒽环类药物的剂量。他成功地实现了分子缓解，并保持这种状态4年。体外外周单核细胞药物敏感性试验表明，缓解期患者的样本对各种抗癌药物的敏感性高于健康志愿者的样本。减少剂量化疗可能是线粒体疾病患者的有效治疗选择，因为暴露于氧化应激升高可能导致这些患者的药物敏感性增加。

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A case of acute promyelocytic leukemia complicated by mitochondrial disease.

A 15-year-old boy with congenital mitochondrial disease was diagnosed with acute promyelocytic leukemia. He was treated with all-trans retinoic acid, and his anthracycline dose was reduced in response to his underlying condition. He successfully achieved molecular remission and maintained this state for 4 years. In vitro drug sensitivity testing in peripheral mononuclear cells suggests that samples from patients in remission show higher sensitivity to various anticancer drugs than samples from healthy volunteers. Reduced-dose chemotherapy could be a valid treatment option for patients with mitochondrial diseases because exposure to elevated oxidative stress may contribute to increased drug sensitivity in these patients.

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来源期刊

International Journal of Hematology 医学-血液学

CiteScore

3.90

自引率

4.80%

发文量

223

审稿时长

6 months

期刊介绍： The International Journal of Hematology, the official journal of the Japanese Society of Hematology, has a long history of publishing leading research in hematology. The journal comprises articles that contribute to progress in research not only in basic hematology but also in clinical hematology, aiming to cover all aspects of this field, namely, erythrocytes, leukocytes and hematopoiesis, hemostasis, thrombosis and vascular biology, hematological malignancies, transplantation, and cell therapy. The expanded [Progress in Hematology] section integrates such relevant fields as the cell biology of stem cells and cancer cells, and clinical research in inflammation, cancer, and thrombosis. Reports on results of clinical trials are also included, thus contributing to the aim of fostering communication among researchers in the growing field of modern hematology. The journal provides the best of up-to-date information on modern hematology, presenting readers with high-impact, original work focusing on pivotal issues.