吃高脂肪/高碳水化合物的饮食可以增强吗啡耐受性,而吃生酮饮食可以减轻雄性大鼠的吗啡戒断。

IF 4.2 3区 医学 Q1 PHARMACOLOGY & PHARMACY
Nina M. Beltran , Leslie L. Sullivan , Gabriela M. Naime , Vanessa Minervini , Katherine M. Serafine
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引用次数: 0

摘要

肥胖与止痛药(即阿片类药物)的高处方率有关。然而,目前尚不清楚阿片类药物的敏感性是否会因饮食而改变,特别是脂肪和碳水化合物的摄入。高脂肪/高碳水化合物饮食会导致体重增加,而高脂肪/低碳水化合物饮食(即生酮饮食)则会导致体重减轻。在本报告中,雄性spraguedawley大鼠(n=7-8/饮食组)食用标准的高脂肪/高碳水化合物或生酮饮食。在生理盐水或累积剂量吗啡(0.32-56 mg/kg;i.p)。急性吗啡试验结束后,每天给大鼠两次吗啡,每3天增加四分之一log剂量(3.2 ~ 56 mg/kg;灌胃19 d诱导依赖并评价耐受性。接下来,评估纳曲酮沉淀戒断。根据先前的数据,假设吃高脂肪/高碳水化合物饮食的老鼠的耐受性会更大,而吃生酮饮食的老鼠的戒断会不那么严重。急性剂量吗啡诱导的抗避孕作用在各组间具有可比性,与饮食无关。此外,各组大鼠均对吗啡产生耐受性;然而,与那些吃生酮饮食的老鼠相比,吃高脂肪/高碳水化合物饮食的老鼠的耐受性更大。吃生酮饮食的老鼠比其他组的老鼠表现出更少的戒断症状。这些结果表明,饮食摄入可能以与慢性疼痛管理和阿片类药物使用障碍相关的方式影响吗啡敏感性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Eating a high fat/high carbohydrate diet enhances morphine tolerance, while eating a ketogenic diet mitigates morphine withdrawal in male rats
Obesity is associated with greater prescription rates of pain-relieving drugs (i.e., opioids). However, it is not known if opioid sensitivity is altered by diet, in particular with regard to fat and carbohydrate consumption. While eating a high fat/high carbohydrate diet leads to weight gain, a high fat/low carbohydrate diet (i.e., a ketogenic diet) leads to weight loss. In this report, male Sprague-Dawley rats (n = 7–8/dietary group) ate either a standard, high fat/high carbohydrate, or ketogenic diet. Morphine-induced antinociception was evaluated using the warm water tail withdrawal procedure following saline or cumulative doses of morphine (0.32–56 mg/kg; i.p.). After acute morphine testing, rats were administered morphine twice-daily, increasing in quarter log doses every 3 days (3.2–56 mg/kg; i.p) for 19 days to induce dependence and evaluate tolerance. Next, naltrexone-precipitated withdrawal was evaluated. Based on previous data, it was hypothesized that the magnitude of tolerance would be greater from eating a high fat/high carbohydrate diet, while withdrawal would be less severe for rats eating a ketogenic diet. Antinociception induced by acute doses of morphine was comparable among groups, regardless of diet. Further, rats in all groups developed tolerance to morphine; however, the magnitude of tolerance was greater for rats eating the high fat/high carbohydrate diet as compared to those eating a ketogenic diet. Rats eating a ketogenic diet displayed less severe withdrawal than rats in other groups. These results suggest that dietary intake can impact morphine sensitivity in ways that might be relevant for chronic pain management and opioid use disorder.
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来源期刊
CiteScore
9.00
自引率
0.00%
发文量
572
审稿时长
34 days
期刊介绍: The European Journal of Pharmacology publishes research papers covering all aspects of experimental pharmacology with focus on the mechanism of action of structurally identified compounds affecting biological systems. The scope includes: Behavioural pharmacology Neuropharmacology and analgesia Cardiovascular pharmacology Pulmonary, gastrointestinal and urogenital pharmacology Endocrine pharmacology Immunopharmacology and inflammation Molecular and cellular pharmacology Regenerative pharmacology Biologicals and biotherapeutics Translational pharmacology Nutriceutical pharmacology.
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