蛋白酶体：抗细菌先天免疫中的一个抗生素库

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2025-05-15 DOI:10.1016/j.molcel.2025.04.025

Yi Zheng, Chengjiang Gao

引用次数: 0

摘要

蛋白酶体除降解蛋白质外，其功能仍是一个谜。Goldberg等人证明蛋白酶体可以将蛋白质加工成抗菌肽（AMPs）以抵御细菌感染，1揭示了蛋白酶体在先天免疫中的新功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Proteasome: An antibiotic arsenal in anti-bacterial innate immunity

The function of the proteasome besides degrading protein remains enigmatic. Goldberg et al. demonstrate that proteasomes can process proteins into antimicrobial peptides (AMPs) to ward off bacterial infection,¹ revealing a new function of proteasomes in innate immunity.

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.