无产患者引产后获得性因子VIII缺乏。

IF 0.1 Q4 OBSTETRICS & GYNECOLOGY

Case Reports in Perinatal Medicine Pub Date : 2024-03-11 eCollection Date: 2024-01-01 DOI:10.1515/crpm-2023-0004

Nawras Zayat, Shirley Huang, Anthony Filipovic, Lorie Bartley, Wissam Akkary

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引用次数: 0

摘要

目的：介绍一例获得性凝血因子VIII缺乏症，并描述其诊断和治疗的挑战。病例介绍：一名31岁妇女在引产时被诊断为获得性因子VIII缺乏症。由于硬膜外血肿形成、术后手术部位长时间出血和皮下血肿，她的分娩和术后过程都很复杂。治疗包括血液制品、人因子7、利妥昔单抗和类固醇减量。结论：获得性因子VIII缺乏症的诊断具有挑战性，在长期出血并伴有活化部分凝血活酶时间延长（aPTT）的患者的鉴别诊断中应予以考虑。

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Acquired factor VIII deficiency in a nulliparous patient undergoing induction of labor.

Objectives: To present a case of acquired factor VIII deficiency in the setting of labor and describe the challenges of its diagnosis and treatment.

Case presentation: A 31-year-old woman was diagnosed with acquired factor VIII deficiency while undergoing induction of labor. Her labor and post operative course were complicated by epidural hematoma formation, prolonged postoperative surgical site bleeding, and subcutaneous hematoma. Management included blood products, human Factor VII, rituximab, and a steroid taper.

Conclusions: Acquired factor VIII deficiency can be challenging to diagnose and should be considered in the differential diagnosis in patients with prolonged bleeding accompanied by a prolonged activated partial thromboplastin time (aPTT).

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来源期刊

Case Reports in Perinatal Medicine OBSTETRICS & GYNECOLOGY-

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期刊介绍： Case Reports in Perinatal Medicine is a double-blind peer-reviewed journal. The objective of the new journal is very similar to that of JPM. In addition to evidence-based studies, practitioners in clinical practice esteem especially exemplary reports of cases that reveal specific manifestations of diseases, its progress or its treatment. We consider case reports and series to be brief reports describing an isolated clinical case or a small number of cases. They may describe new or uncommon diagnoses, unusual outcomes or prognosis, new or infrequently used therapies and side effects of therapy not usually discovered in clinical trials. They represent the basic concept of experiences for studies on representative groups for further evidence-based research. The potential roles of case reports and case series are: Recognition and description of new diseases Detection of drug side effects (adverse or beneficial) Study of mechanisms of disease Medical education and audit Recognition of rare manifestations of disease.