Luis A Bello-Perez, Edith Agama-Acevedo, Josue Moreno-Zaragoza, Perla Osorio-Diaz, Daniel Arrieta-Baez
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High-amylose starch forms complexes with bioactive compounds present in the Amphipterygium adstringent ethanol extract.
Plants have been used for thousands of years to treat health problems. The bioactive compounds in parts of them are associated with cures for some diseases. The protection and release of bioactive compounds (bioaccessibility) are key issues in producing a therapeutic effect. Amylose and amylopectin, starch macromolecules, produce interactions with bioactive compounds, resulting in the formation of complexes. This study aimed to analyze the bioactive compounds in the complex produced between Amphipterygium adstringens (AA, cuachalalate) extract and high-amylose starch. Both the extract and the complex were analyzed by ultra-high-resolution liquid chromatography. AA extract showed compounds associated with antioxidant, anti-inflammatory, antibiotic, and anti-tumoral effects. The complex showed reduced compounds in the extract, and some compounds were not complexed with starch. The bioactive compounds present in the extract of medicinal plants can be complexed with amylose for their protection when ingested orally.
期刊介绍：
The Journal of Pharmaceutical Sciences will publish original research papers, original research notes, invited topical reviews (including Minireviews), and editorial commentary and news. The area of focus shall be concepts in basic pharmaceutical science and such topics as chemical processing of pharmaceuticals, including crystallization, lyophilization, chemical stability of drugs, pharmacokinetics, biopharmaceutics, pharmacodynamics, pro-drug developments, metabolic disposition of bioactive agents, dosage form design, protein-peptide chemistry and biotechnology specifically as these relate to pharmaceutical technology, and targeted drug delivery.
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