花青素通过nrf2依赖机制改善线粒体功能,减轻肺动脉高压和相关心力衰竭。

IF 1.5 4区 医学 Q3 PERIPHERAL VASCULAR DISEASE
Xiao Liu, Xiaoli Tan, Yidan Su, Luohao Zou, Wenhui Yuan, Changqing Yu
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引用次数: 0

摘要

背景:肺血管内皮细胞线粒体功能障碍是肺动脉高压(PAH)的重要发病机制之一。花青素可以保护线粒体功能,但花青素是否可以预防PAH及其相关机制尚未见报道。方法:采用慢性缺氧21 d鼠PAH模型,观察花青素处理21 d后血流动力学、组织病理学及血管内皮功能的变化。结果:我们发现花青素治疗可改善肺内皮功能,血管重构和相关的右心衰。在机制上,我们发现花青素处理促进了Nrf2的核易位,改善了受损的线粒体功能。花青素对线粒体功能调节的有益作用被Nrf2的抑制所抵消。最后,在Nrf2缺陷小鼠中,花青素对PAH的保护作用基本消失。结论:总的来说,我们发现花青素通过nrf2依赖机制通过改善线粒体功能来减轻PAH和相关的右心衰,这表明花青素可能代表了PAH的一种新的治疗潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anthocyanin attenuates pulmonary arterial hypertension and associated heart failure via improving mitochondrial function through Nrf2-dependent mechanism.

Background: Mitochondrial dysfunction of pulmonary vascular endothelial cells is one of the important pathogenesis of pulmonary arterial hypertension (PAH). Anthocyanin can protect mitochondrial function, but whether anthocyanin can prevent PAH and its related mechanism has not been reported.

Methods: Using rodent PAH models induced by chronic hypoxia for 21 days, we investigated the changes of hemodynamics, histopathology and vascular endothelial function after anthocyanin treatment for 21 days.

Results: We found that anthocyanin treatment improved pulmonary endothelial function, vascular remodeling and associated right heart failure. Mechanistically, we found that anthocyanin treatment promoted the nucleus translocation of Nrf2 and improved the impaired mitochondrial function. The beneficial effects of anthocyanin on regulation of mitochondrial function were abolished by inhibition of Nrf2. Finally, in Nrf2 deficient mice, the protective effects of anthocyanin on PAH were largely vanished.

Conclusions: Collectively, we showed that anthocyanin attenuated PAH and associated right heart failure via improving mitochondrial function through Nrf2-dependent mechanism, suggesting that anthocyanin may represent a novel therapeutic potential for PAH.

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来源期刊
CiteScore
3.90
自引率
0.80%
发文量
66
审稿时长
6-12 weeks
期刊介绍: Clinical and Experimental Hypertension is a reputable journal that has converted to a full Open Access format starting from Volume 45 in 2023. While previous volumes are still accessible through a Pay to Read model, the journal now provides free and open access to its content. It serves as an international platform for the exchange of up-to-date scientific and clinical information concerning both human and animal hypertension. The journal publishes a wide range of articles, including full research papers, solicited and unsolicited reviews, and commentaries. Through these publications, the journal aims to enhance current understanding and support the timely detection, management, control, and prevention of hypertension-related conditions. One notable aspect of Clinical and Experimental Hypertension is its coverage of special issues that focus on the proceedings of symposia dedicated to hypertension research. This feature allows researchers and clinicians to delve deeper into the latest advancements in this field. The journal is abstracted and indexed in several renowned databases, including Pharmacoeconomics and Outcomes News (Online), Reactions Weekly (Online), CABI, EBSCOhost, Elsevier BV, International Atomic Energy Agency, and the National Library of Medicine, among others. These affiliations ensure that the journal's content receives broad visibility and facilitates its discoverability by professionals and researchers in related disciplines.
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