星形胶质细胞中的Ca2+波：计算模型和实验数据。

IF 4.2 3区医学 Q2 NEUROSCIENCES

Frontiers in Cellular Neuroscience Pub Date : 2025-03-28 eCollection Date: 2025-01-01 DOI:10.3389/fncel.2025.1536096

Rosa Musotto, Ulderico Wanderlingh, Giovanni Pioggia

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引用次数: 0

摘要

本文探讨了钙波在星形胶质细胞内传播的不同计算模型。通过对goldbetter、De Young-Keizer、Atri、Li-Rinzel和De pitt的模型和实验数据的比较分析，该研究强调了模型对理解钙动力学的贡献。追踪从简单到复杂模型的演变，这项工作强调了整合实验数据的重要性，以便进一步完善这些模型。这些结果有助于提高我们对星形胶质细胞生理功能的理解，表明建立更准确的星形胶质细胞模型的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Ca²⁺ waves in astrocytes: computational modeling and experimental data.

This paper examines different computational models for Calcium wave propagation in astrocytes. Through a comparative analysis of models by Goldbeter, De Young-Keizer, Atri, Li-Rinzel, and De Pittà and of experimental data, the study highlights the model contributions for the understanding of Calcium dynamics. Tracing the evolution from simple to complex models, this work emphasizes the importance of integrating experimental data in order to further refine these models. The results allow to improve our understanding of the physiological functions of astrocytes, suggesting the importance of more accurate astrocyte models.

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来源期刊

Frontiers in Cellular Neuroscience NEUROSCIENCES-

CiteScore

7.90

自引率

3.80%

发文量

627

审稿时长

6-12 weeks

期刊介绍： Frontiers in Cellular Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the cellular mechanisms underlying cell function in the nervous system across all species. Specialty Chief Editors Egidio D‘Angelo at the University of Pavia and Christian Hansel at the University of Chicago are supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.