关于银屑病关节炎,老鼠教会了我们什么?

IF 4.3 2区 医学 Q1 RHEUMATOLOGY
Current opinion in rheumatology Pub Date : 2025-07-01 Epub Date: 2025-04-24 DOI:10.1097/BOR.0000000000001093
Peggy M Randon, Johann E Gudjonsson, Nicole L Ward
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引用次数: 0

摘要

综述目的:本文综述了银屑病关节炎(PsA)的重要小鼠模型,揭示了它们在人类疾病模型中的优缺点。最新发现:两种新建立的小鼠PsA模型验证了NF-κB信号的致病作用,并确定了CD8 +和CD4 + FoxP3 + T细胞在特定PsA表型发展中的致病作用。IkbkbGoF/GoF模型表明,Ikbkb中功能获得性突变的纯合性导致FoxP3 + CD25 + IL-17A + Tregs的扩增,从而导致指甲和皮肤的指突炎、脊椎炎和psa样变化的发生,当转移到野生型小鼠时,再现了这些结果。人源化小鼠PsA模型(Hu-PsA)证实,将PsA患者血清和pbmc引入NSG-SGM3小鼠具有诱导不同PsA亚型的能力,并确定CD8 + IL-32 + CXCL14 + T细胞和免疫球蛋白在疾病发展中的关键作用。摘要:小鼠PsA模型是阐明疾病发病机制、生物标志物鉴定和可能有助于发现治疗方法的强大研究工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
What are mice teaching us about psoriatic arthritis?

Purpose of review: This review summarizes important mouse models of psoriatic arthritis (PsA), shedding light on their advantages and disadvantages in modeling human disease.

Recent findings: Two newly created mouse models of PsA validate NF-κB signaling as disease-causing and identify pathogenic roles for CD8 + and CD4 + FoxP3 + T cells in the development of specific PsA phenotypes. The IkbkbGoF/GoF model demonstrates that homozygosity for a gain-of-function mutation in Ikbkb results in expansion of FoxP3 + CD25 + IL-17A + Tregs that lead to the development of dactylitis, spondylitis and PsA-like changes to the nails and skin, and when transferred to wildtype mice, reproduce these outcomes. The humanized mouse PsA model (Hu-PsA) establishes that introduction of PsA patient sera and PBMCs into NSG-SGM3 mice has the capacity to elicit distinct subtypes of PsA and identifies a critical role for CD8 + IL-32 + CXCL14 + T cells and immunoglobulins in disease development.

Summary: Mouse models of PsA are powerful research tools for elucidating pathogenesis of disease, biomarker identification and may assist in the discovery of a cure.

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来源期刊
Current opinion in rheumatology
Current opinion in rheumatology 医学-风湿病学
CiteScore
9.70
自引率
2.00%
发文量
89
审稿时长
6-12 weeks
期刊介绍: A high impact review journal which boasts an international readership, Current Opinion in Rheumatology offers a broad-based perspective on the most recent and exciting developments within the field of rheumatology. Published bimonthly, each issue features insightful editorials and high quality invited reviews covering two or three key disciplines which include vasculitis syndromes, medical physiology and rheumatic diseases, crystal deposition diseases and rheumatoid arthritis. Each discipline introduces world renowned guest editors to ensure the journal is at the forefront of knowledge development and delivers balanced, expert assessments of advances from the previous year.
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