甲状腺弥漫性[18F] AlF-NOTA-FAPI-04摄取在PET/CT上的临床意义

IF 3.1 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

EJNMMI Research Pub Date : 2025-04-25 DOI:10.1186/s13550-025-01231-9

Ying Kou, Wei Diao, Zhuzhong Cheng, Yutang Yao

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引用次数: 0

摘要

背景：许多接受[18F] AlF-NOTA-FAPI-04 (18F- fapi) PET/CT检查的患者表现为弥漫性甲状腺摄取。由于对甲状腺弥漫性18F-FAPI摄取的生理和非肿瘤原因的了解有限，这些发现为准确解释带来了挑战。本回顾性研究检查了接受18F-FAPI PET/CT成像并伴有弥漫性甲状腺摄取的患者。定量评估正常甲状腺摄取，比较正常甲状腺和病变甲状腺的18F-FAPI摄取，并探讨其与弥漫性甲状腺摄取的潜在关联。本研究可提高18F-FAPI PET/CT对甲状腺诊断的准确性，促进对18F-FAPI PET/CT弥漫性甲状腺摄取的适当管理。结果：根据纳入标准，共纳入38例患者。正常甲状腺的平均SUVmax、SUVmean、TBR分别为7.09±3.83、4.24±2.25、3.93±1.73。定量分析显示，左右甲状腺叶对18F-FAPI摄取无明显不对称(SUVmax：右侧6.69±2.96 vs左侧6.54±3.28,p = 0.84；平均：右侧4.19±1.73 vs左侧4.18±1.97,p = 0.98)，与弥漫性摄取模式一致。桥本甲状腺炎、血清TSH水平和弥漫性甲状腺摄取程度之间无显著相关性（SUVmax、SUVmean和TBR均p < 0.05）。此外，性别、年龄、免疫治疗和弥漫性甲状腺摄取之间没有关联（p < 0.05）。结论：甲状腺弥漫性摄取18F-FAPI可能与桥本甲状腺炎或血清TSH水平异常无关。18F-FAPI PET/CT扫描上的病变可能很难发现，因为正常甲状腺组织中有适度的摄取。

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Clinical significance of diffuse [¹⁸F] AlF-NOTA-FAPI-04 uptake in the thyroid on PET/CT imaging.

Background: Many patients undergoing [¹⁸F] AlF-NOTA-FAPI-04 (¹⁸F-FAPI) PET/CT demonstrated diffuse thyroid uptake. These findings created challenges for accurate interpretation due to the limited understanding of physiological and non-oncologic causes of diffuse ¹⁸F-FAPI uptake in the thyroid. This retrospective study examined patients who underwent ¹⁸F-FAPI PET/CT imaging with diffuse thyroid uptake. It quantitatively assessed normal thyroid uptake, compared ¹⁸F-FAPI uptake between normal and diseased thyroids, and explored potential associations with diffuse thyroid uptake. The study may improve the accuracy of ¹⁸F-FAPI PET/CT interpretation for thyroid and facilitate appropriate management of diffuse thyroid uptake on ¹⁸F-FAPI PET/CT.

Results: A total of 38 patients were included in this study based on the inclusion criteria. The mean SUVmax, SUVmean, and TBR of normal thyroid were 7.09 ± 3.83, 4.24 ± 2.25 and 3.93 ± 1.73, respectively. Quantitative analysis revealed no significant asymmetry in ¹⁸F-FAPI uptake between the right and left thyroid lobes (SUVmax: right 6.69 ± 2.96 vs. left 6.54 ± 3.28, p = 0.84; SUVmean: right 4.19 ± 1.73 vs. left 4.18 ± 1.97, p = 0.98), consistent with the diffuse uptake pattern observed. There was no significant correlation between Hashimoto thyroiditis, serum TSH levels, and the degree of diffuse thyroid uptake (all p > 0.05 for SUVmax, SUVmean, and TBR). Furthermore, no association was observed between sex, age, immunotherapy, and diffuse thyroid uptake (p > 0.05).

Conclusions: Diffuse uptake of ¹⁸F-FAPI in the thyroid may not significantly relate to Hashimoto thyroiditis or abnormal serum TSH levels. Lesions on ¹⁸F-FAPI PET/CT scans might be hard to detect due to the moderate uptake in normal thyroid tissue.

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来源期刊

EJNMMI Research RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING&nb-

CiteScore

5.90

自引率

3.10%

发文量

审稿时长

13 weeks

期刊介绍： EJNMMI Research publishes new basic, translational and clinical research in the field of nuclear medicine and molecular imaging. Regular features include original research articles, rapid communication of preliminary data on innovative research, interesting case reports, editorials, and letters to the editor. Educational articles on basic sciences, fundamental aspects and controversy related to pre-clinical and clinical research or ethical aspects of research are also welcome. Timely reviews provide updates on current applications, issues in imaging research and translational aspects of nuclear medicine and molecular imaging technologies. The main emphasis is placed on the development of targeted imaging with radiopharmaceuticals within the broader context of molecular probes to enhance understanding and characterisation of the complex biological processes underlying disease and to develop, test and guide new treatment modalities, including radionuclide therapy.