{"title":"微小病变与原发性胆道胆管炎的罕见关联：1例报告。","authors":"Neeraj Sharma, Heidi Duong, Bahman Moghadam, Tachaporn Sangwattanarat","doi":"10.1159/000545015","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Primary biliary cholangitis (PBC) is a chronic and progressive cholestatic liver disease that is autoimmune in nature and characterized by circulating anti-mitochondrial antibodies. A wide range of autoimmune disorders have been concomitantly observed in patients with PBC, and although quite rare PBC has been associated with a wide variety of renal disorders. Glomerular diseases have a very rare association with PBC, and these include diffuse membranous glomerulonephritis and minimal change disease, which have been sparsely described in prior literature.</p><p><strong>Presentation: </strong>Here we present a case of biopsy-proven minimal change disease in a patient with PBC treated with a course of steroids and achieving complete recovery.</p><p><strong>Conclusion: </strong>Establishing the relationship between PBC and MCD has been limited in prior literature and should be kept in mind to bring forth this rare association, which may help dictate future treatment courses.</p>","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":"15 1","pages":"78-82"},"PeriodicalIF":0.7000,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054988/pdf/","citationCount":"0","resultStr":"{\"title\":\"Rare Association between Minimal Change Disease and Primary Biliary Cholangitis: Case Report.\",\"authors\":\"Neeraj Sharma, Heidi Duong, Bahman Moghadam, Tachaporn Sangwattanarat\",\"doi\":\"10.1159/000545015\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Primary biliary cholangitis (PBC) is a chronic and progressive cholestatic liver disease that is autoimmune in nature and characterized by circulating anti-mitochondrial antibodies. A wide range of autoimmune disorders have been concomitantly observed in patients with PBC, and although quite rare PBC has been associated with a wide variety of renal disorders. Glomerular diseases have a very rare association with PBC, and these include diffuse membranous glomerulonephritis and minimal change disease, which have been sparsely described in prior literature.</p><p><strong>Presentation: </strong>Here we present a case of biopsy-proven minimal change disease in a patient with PBC treated with a course of steroids and achieving complete recovery.</p><p><strong>Conclusion: </strong>Establishing the relationship between PBC and MCD has been limited in prior literature and should be kept in mind to bring forth this rare association, which may help dictate future treatment courses.</p>\",\"PeriodicalId\":9599,\"journal\":{\"name\":\"Case Reports in Nephrology and Dialysis\",\"volume\":\"15 1\",\"pages\":\"78-82\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2025-04-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054988/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Case Reports in Nephrology and Dialysis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1159/000545015\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Case Reports in Nephrology and Dialysis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000545015","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
Rare Association between Minimal Change Disease and Primary Biliary Cholangitis: Case Report.
Introduction: Primary biliary cholangitis (PBC) is a chronic and progressive cholestatic liver disease that is autoimmune in nature and characterized by circulating anti-mitochondrial antibodies. A wide range of autoimmune disorders have been concomitantly observed in patients with PBC, and although quite rare PBC has been associated with a wide variety of renal disorders. Glomerular diseases have a very rare association with PBC, and these include diffuse membranous glomerulonephritis and minimal change disease, which have been sparsely described in prior literature.
Presentation: Here we present a case of biopsy-proven minimal change disease in a patient with PBC treated with a course of steroids and achieving complete recovery.
Conclusion: Establishing the relationship between PBC and MCD has been limited in prior literature and should be kept in mind to bring forth this rare association, which may help dictate future treatment courses.
期刊介绍：
This peer-reviewed online-only journal publishes original case reports covering the entire spectrum of nephrology and dialysis, including genetic susceptibility, clinical presentation, diagnosis, treatment or prevention, toxicities of therapy, critical care, supportive care, quality-of-life and survival issues. The journal will also accept case reports dealing with the use of novel technologies, both in the arena of diagnosis and treatment. Supplementary material is welcomed.
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