自身免疫性疾病中肠道菌群对B细胞的影响。

IF 6 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Medicine Pub Date : 2025-04-22 DOI:10.1186/s10020-025-01195-5

Lun He, Xin Li, Shan Jiang, Yanhua Ou, Shanshan Wang, Na Shi, Zhongshan Yang, Jia-Li Yuan, Gregg Silverman, Haitao Niu

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引用次数: 0

摘要

越来越多的证据表明，肠道菌群群落和人体免疫系统共存并相互影响，并且有许多报道表明肠道菌群的特定变化与自身免疫性疾病的发生之间存在相关性。B淋巴细胞在调节肠道菌群和自身免疫性疾病中发挥核心作用。在这里，我们总结了肠道微生物-B细胞途径对自身免疫性疾病的影响以及B细胞如何调节微生物的证据，这为鉴定潜在的治疗靶点和相关领域提供了相关的机制见解。

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The influence of the gut microbiota on B cells in autoimmune diseases.

Mounting evidence shows that gut microbiota communities and the human immune system coexist and influence each other, and there are a number of reports of a correlation between specific changes in gut microbiota and the occurrence of autoimmune diseases. B lymphocytes play a central role in the regulation of both gut microbiota communities and in autoimmune diseases. Here, we summarize evidence of the influence of gut microbiota-B cell pathways on autoimmune diseases and how B cells regulate microorganisms, which provides mechanistic insights with relevance for identification of potential therapeutic targets and related fields.

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来源期刊

Molecular Medicine 医学-生化与分子生物学

CiteScore

8.60

自引率

0.00%

发文量

137

审稿时长

1 months

期刊介绍： Molecular Medicine is an open access journal that focuses on publishing recent findings related to disease pathogenesis at the molecular or physiological level. These insights can potentially contribute to the development of specific tools for disease diagnosis, treatment, or prevention. The journal considers manuscripts that present material pertinent to the genetic, molecular, or cellular underpinnings of critical physiological or disease processes. Submissions to Molecular Medicine are expected to elucidate the broader implications of the research findings for human disease and medicine in a manner that is accessible to a wide audience.