血清尿酸和药物洗脱支架植入术治疗冠状动脉分叉病变。

IF 1.4 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Hongjie Gao, Dongchao Liu, Zheng Xue, Jingxian Qi, Liang Yin, Bing Duan, Lin Wu, Kun Yang, Bulang Gao, Qinying Cao, Jie Mi
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引用次数: 0

摘要

背景:本研究旨在探讨高尿酸血症对冠脉分叉病变药物洗脱支架植入术预后的影响及尿酸水平对预后的预测价值。方法:对冠状动脉分叉病变行药物洗脱支架置入术的患者进行回顾性分析。对临床、介入及随访资料进行分析。结果:308例患者共入组,根据尿酸水平分为3组:Q1组(n =105)、Q2组(n =101)、Q3组(n =102)。PCI前,冠状动脉主干狭窄率为0.85(0.80,0.90),分支狭窄率为0.50(0.50,0.50)。经PCI +支架置入后,冠状动脉主干狭窄率为0.20(0.20,0.20),分支狭窄率为0.50(0.50,0.50)。随访36个月,7例患者因不同原因死亡,Q1组5例,Q2组1例,Q3组1例,96例患者再次入院治疗心绞痛,其中Q1组18例,Q2组29例,Q3组49例。27例患者因病情恶化而经历血运重建术,其中Q1组6例,Q2组7例,Q3组14例。结论:尿酸水平升高是心源性再入院的独立危险因素,而不是冠状动脉分叉病变患者药物洗脱支架植入术后全因死亡率和血运重建术的独立危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Serum uric acid and drug-eluting stent implantation for coronary bifurcated lesions.

Background: The aim of this study is to investigate the effect of hyperuricemia on prognosis of drug-eluting stent implantation for coronary bifurcated lesions and the value of uric acid levels in predicting the prognosis.

Methods: Patients with coronary bifurcation lesions treated with drug-eluting stent implantation were retrospectively enrolled. The clinical, interventional and follow-up data were analyzed.

Results: Totally, 308 patients were enrolled and were divided into three groups according to the uric acid levels: group Q1 (N.=105), Q2 (N.=101), and Q3 (N.=102). Before PCI, the stenosis rate was 0.85 (0.80, 0.90) for the main coronary artery and 0.50 (0.50, 0.50) for the branch artery. After PCI and stent deployment, the arterial stenosis rate was 0.20 (0.20, 0.20) for the main coronary artery and 0.50 (0.50, 0.50) for the branch artery. At 36-month follow-up, seven patients died of different reasons, with five patients in group Q1, one in group Q2, and one in group Q3, 96 patients were readmitted for treatment of angina pectoris, with 18 in Q1 group, 29 in Q2 group, and 49 in Q3 group. Twenty-seven patients experienced revascularization because of deterioration of the condition, including six patients in group Q1, seven in group Q2, and 14 in group Q3. After correction of the confounding factors, the readmission rate of angina pectoris was significantly (P<0.001) increased with the increase of the uric acid level: Q3 vs. Q1 (220.47/1000 vs. 66.69/1000 person years, HR 3.65, 95% CI 1.92-6.96) and Q2 vs. Q1 (113.76/1000 vs. 66.69/1000 person years, HR 2.20,95% CI 1.16-4.18).

Conclusions: Increased uric acid level is an independent risk factor for cardiogenic readmission rather than for all-cause mortality and revascularization after drug-eluting stent implantation for patients with coronary bifurcation lesions.

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来源期刊
Minerva cardiology and angiology
Minerva cardiology and angiology CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
2.60
自引率
18.80%
发文量
118
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